Anadrome

Anadrome (pronounced an-uh-drohm)

(1) A word which forms a different word when spelled backwards.

(2) In pre-modern medical jargon, the upward path of various elements (pain, blood etc) (obsolete).

Circa 1961 (in this context): The construct was ana- +‎ -drome.  Ana was from the Ancient Greek ἀνα- (ana-), from ἀνά (aná) (backward in direction, reversed) and drome was from the Ancient Greek δρόμος (dromos) (running; racetrack); the surface analysis of anadrome thus can be understood as “going backwards”.  Confusingly however, the Greek prefix aná was appended also to convey the notion of “up, above, upward”, (2) “again”, (3) “thoroughly”, (4) “against”, (5) “distal, away from” and (6) “to grow or change in place; functionally similar”.  So, a deconstruction alone would not be definitive and the meaning is established through context.  The longest accepted anadrome in English is believed to be the pair desserts/stressed but among the dozens which exist, it is god/dog which seems most to amuse students.  The coining (or possibly a re-purposing of the earlier medical jargon) of anadrome was credited to Martin Gardner (1914–2010) who is said to have added it in a 1961 re-publication of Oddities and Curiosities of Words and Literature (1875) by Charles C. Bombaugh (1828-1906) but the word doesn't appear in at least some of the 1961 editions and at least the spike in use may better be attributed to the reclusive and eccentric Dmitri Borgmann (1927–1985) a German-American author regarded still as something of the “high priest of recreational linguistics”.  In his introduction, Mr Gardner does pay tribute to Mr Borgmann as one of the “outstanding creators of word puzzles”.  Anadrome & anadromy are nouns and anadromous & anadromic are adjectives; the noun plural is anadromes.

An young anadromous Atlantic salmon, still resident in the freshwater in which it was born.  The young salmon are called smolts after they gain a silvery hue and migrate to the ocean.

The adjectival form is used in ichthyology, the term “anadromous fish” describing those species born in freshwater rivers or streams that migrate to the ocean to mature and forage, subsequently returning to freshwater to spawn.  First appearing in scientific papers in 1753, the construct of anadromous was ana- (used here in the sense of “up, above, upward”) + dromos (a running), from dramein (to run).  Though the usual natural processes, anadromous fish have evolved with an environmental adaptation called osmoregulation which enables them seamlessly to adapt to changing salinities; that’s what makes it possible for them to live in both aquatic habitats (salt & freshwater).  The process is dynamic as it must be because while some notional freshwater species might move into a sea or ocean only for weeks, others can stay there for years because that’s where they undergo most of their growing cycle.  Remarkably, and using a mechanism not wholly understood (use of the Earth’s magnetic field an intriguing theory), after perhaps years the fish return to their exact natal streams to reproduce.  For freshwater ecosystems, the behaviour is not a mere zoological curiosity because as schools return from their time in saltwater, they bring with them marine-derived phosphorus & nitrogen, “topping up” the elements on which the health of the spawning grounds depends.  Anadromous fish are thus listed as keystone species, some salmon the best known examples.  An anadromic fish swimming to or from the ocean could be said to be proceeding anadromically but the adverb is non-standard.

A catadromous freshwater American eel, slithering out of a pipe, possibly heading back to the ocean, catadromically (again, a non standard adverb).

The companion term is “catadromous fish”, describing species born in salt water that mature in fresh water and return to the sea to spawn, certain eels the best known.  The mysterious European eel exerted a particular fascination upon the natural scientists of Antiquity, Aristotle (384-322 BC) writing the earliest known study although the findings truly were speculative, his novel idea being the creatures were born of “earth worms” which, he suggested, were formed of mud, growing from the “guts of wet soil”.  In the absence of any better theory or observational data, the notion for some time held sway and not for centuries was spontaneous generation disproven.  It wasn’t until the eighteenth century researchers perfected their techniques of dissection and confirmed eels really are fish although, while in recent years it has been possible to effect breeding of eels in captivity, because of the difficulty of replicating at scale the multi-aquatic environment needed for the life-cycle, it’s unlikely any time soon to become commercially viable.  Largely because of demand from the Far East (especially Japan) the European freshwater glass eel has become threatened with smuggling rife, the decline in availability encouraging a trade in the American eel, something which has created problems because of the involvement of transnational crime groups.

25 Franc postage stamp, issued to mark the independence of Upper Volta, 1960.

Although in a sense belonging to the discipline of structural linguistics, the word anadrome (in this context) seems in this context to have come into use (“re-invented” as it were) only in the mid twentieth century and it emerged not from academia but recreational wordplay: It was a “fun word” which migrated to reference books when editors and compliers noticed it appearing in published word games, logology and puzzle culture.  While having no place in formal linguistic theory, it is used as a teaching aid, apparently on the basis of “training the mind to be flexible”.  The model is believed to be the better known “palindrome” (a word, line, verse, number, sentence, etc reading the same backward as forward), in used since the 1630s.  In logology (recreational linguistics, ie puzzles, word-games and such), there is a great satisfaction in having a coined word “succeed” in the sense of even a limited, specialized acceptance which is why the community has come up with synonyms including: (1) semordnilap (“palindromes” spelled backwards) (2) levidrome (the “Levi” element from the given name of the coiner), (3) reversgram and (4) heteropalindrome (the hetro- prefix a learned borrowing from Ancient Greek ἕτερος (héteros) (other, another, different).  There was a suggestion such words should be called a "volta" (from the Italian volta (which can be used to mean "to turn")) but the idea never caught on.

H.R. Haldeman (1926–1993; White House chief of staff 1969-1973 right) and Richard Nixon (1913-1994; US VPOTUS 1953-1961 & POTUS 1969-1974) doing paperwork (ie shredding evidence) in the White House.

The word did however find a place in geopolitical history.  Flowing south into the West African nation of Ghana from the highlands of Burkina Faso, the Volta River was in the late fifteenth century named by Portuguese gold traders.  Because it was their furthest extent of exploration before returning, the name was appropriate, volta being Portuguese for “turn” or “twist”, thus the common term “river of return”.  As part of the unravelling of the French colonial empire, the République de Haute-Volta (Republic of Upper Volta) was in 1958 created as a self-governing state within the French Community; previously it had been part of the French Union in West Africa as the French Upper Volta.  Independence was granted in 1960 and in 1984 the nation's name was changed to Burkina Faso.  When president, Richard Nixon sarcastically would use “Upper Volta” as a reference to any “unimportant country”, especially if compelled by the conventions of diplomacy to spend time exchanging “pointless pleasantries” with the dignitaries in their visiting delegations.  Sometimes, when someone from the State Department displeased him (a not infrequent happening), darkly he would mutter about having them posted as “ambassador to Upper Volta”, a place Nixon thought a kind of “diplomatic Gulag”.

62¢ postage stamp issued in 2015 by Deutsche Post (The German post office, now a brand of DHL Group) to mark the 200^th anniversary of the birth of Otto von Bismarck (1815-1989; chancellor of the German Empire (the “Second Reich”) 1871-1890).

Among politicians, the phenomenon of an at least affected indifference to the affairs of countries in which no matters of national interest seem obvious is well documented.  His eyes darting east & west, Otto von Bismarck claimed he “never troubled to read the mailbag from Constantinople” although he of course at least glanced at every paper.  While the famous phrase attributed to him: “I shall not live to see the Great War, but you will see it, and it will start in the East.” is likely apocryphal, what is verified he did say: “One day the great European war will come out of some damned foolish thing in the Balkans.”  Confidently it may be asserted he read the telegrams from the embassy in Constantinople (modern day Istanbul in the Republic of Türkiye (Turkey)).  While predicting squabbles in the Balkans hardly demanded great statesmanship, his vision of a “big” European war was remarkably prescient although the chain of events which in 1914 triggered the spread of what could have been yet another localized Balkan war was a consequence of the legacy of inter-locking treaties he'd created, his successors less adept in their handling.  Lord Moran (Charles Wilson, 1882-1977; president of the Royal College of Physicians 1941-1949, personal physician to Winston Churchill 1940-1965) in his diary (The Struggle for Survival, 1940–1965 (1966)) on more than one occasion noted Winston Churchill’s (1875-1965; UK prime-minister 1940-1945 & 1951-1955) unconcern about places which had never piqued his interest.  An entry from April 1953 recorded him saying: “‘I have lived seventy-eight years without hearing of bloody places like Cambodia.’  With a whimsical look he strung out half a dozen strange-sounding names.  ‘They have never worried me, and I haven’t worried them.”  Revisiting his thoughts a year on, when being told of troubles in Central America he thought tiresome, Churchill complained: “I’d never heard of this bloody place Guatemala until I was in my seventy-ninth year.” 

Google Ngram

Google Ngram (a quantitative and not qualitative measure): Because of the way Google harvests data for their Ngrams, they’re not literally a tracking of the use of a word in society but can be usefully indicative of certain trends, (although one is never quite sure which trend(s)), especially over decades.  As a record of actual aggregate use, Ngrams are not wholly reliable because: (1) the sub-set of texts Google uses is slanted towards the scientific & academic and (2) the technical limitations imposed by the use of OCR (optical character recognition) when handling older texts (typically a scanner might misread an “f” for a long “s” or a “u” for an “n”) of sometime dubious legibility (a process AI (artificial intelligence) should improve).  Where numbers bounce around, this may reflect either: (1) peaks and troughs in use for some reason or (2) some quirk in the data harvested.

As Google’s Ngram attests, “anadrome” was in use in the nineteenth century, the earliest citation dating from 1840, the use a classic illustration of “lexical overlap” a phenomenon which delights word nerds (an easily delighted lot).  In the mid-late 1800s, anadrome (often written as anadromé, reflecting both the Greek roots and the backgrounds of those using the word) was a technical term seen mostly in botanical and medical publications; it was direct borrowing of the Ancient Greek anadromē (ἀναδρομή) (“an ascent”; “running up”).  Medical dictionaries in the era weren’t new but revised editions were common because advances in observational technologies and techniques meant new entries constantly were required and anadrome seems first to have been used of a variety of “physiological ascents” including (1) Ascending Pain: physical pain starting in the lower limbs or torso and migrating upward, (2) The “upward determination of blood: A rush of blood toward the head or upper body and, best of all (3) Globus Hystericus: The “lump in the throat” sensation described at the time also as the “ascent of the womb”.  While scientifically inaccurate, it was memorable and dated from the era (which lasted well into the twentieth century) when the condition “hysteria” was part of the diagnostic toolkit for physicians assessing female patients.  In botanical use, the meaning was most analogous with the idea of blood flow, botanists describing “upward sap flow” (the ascent of sap through a plant’s vascular system).  What the Ngram has in this case captured is a genuine heteronym (a word that looks the same but has a completely different meaning and subtly different lineage).

Between consenting players only: More than 11 points but don’t try insisting on it in competition or you’ll be blackballed; the Scrabble crew neither forgive nor forget.

The proliferation of synonyms of a word which is little more than a curiosity is an example of why the English language has so many words, most of which are never or rarely used.  The estimates notoriously are vague because there exists no consensus on just what is the definition of a “real word” (which sounds silly but in language there’s no concept like the “real number” in mathematics and, at the margins, disputes are legion).  If one is most accommodating of the definitional spectrum, there may in English be as many as a million words but only 15-20% are thought to be in regular or occasional use.  However, although it has appeared in many lists (often of the strange or obscure), "anadrome" has not received the imprimatur of the major sanctioning bodies setting the rules for the game of competitive Scrabble.  It never appeared in the Collins SOWPODS (an anagram of the two abbreviations OSPD (Official Scrabble Players Dictionary) & OSW (Official Scrabble Words)) or the replacement CSW (Collins Scrabble Words) and nor is it in the NASPA’s (North American Scrabble Players Association) NWL (NASPA Word List).  Quite why Collins replaced the wonderful "SOWPODS" with the dreary "CSW" remains a mystery; more than most, they would know English speakers usually will be pulled to a word with two syllables if the alternative is one of five.  The NASPA Dictionary Committee does accept submissions so anadrome advocates can pursue that course but as a non-standard form, the adverb anadromically definitely has no good prospects.  Those playing at home can of course tolerate a bit of linguistic promiscuity and, provided all players agree, if used, "anadrome" would yield a face value of 11 points (before any double/triple letter or word bonuses) but because there are not eight sequential blank squares on a standard Scrabble board, at least one letter always will attract a multiplier.  For word nerd dissidents unhappy with the dictatorial ways of Scrabble’s ruling ancien régime, there is the scrabblesque (also not a “real word”) “Anadrome the Game” in which "anadrome" is lawful and welcomed.

A brunette era Lindsay Lohan wearing Nahol dress in a black and white rose print by Masai of Copenhagen, rendered as a line drawing by Vovsoft.  The anadrome of “Lohan” is “Nahol”.

Masai describes the Nahol as “a loose, oversized, and comfortable midi-dress, characterized by a V-neck, ¾-length length sleeves, side pockets and an elasticized hem creating a slight balloon effect.”  That it has pockets may be enough of a selling point for women, many designers loath to include them in women’s clothing because any additional bulk might “spoil the line”.  Made with what the manufacturer describes as a “sustainable” (a word that has become the industry’s “new black”) mix of 15% polyamide blend & 85% viscose (said “often” to be FCS (Forest Stewardship Council) certified), the material had a “crinkled” finish in black or printed designs.  It does look comfortably accommodating and, on the move, would "swish" nicely.

Nahol as a proper noun (surname): Dalia Nahol.

While not a recognized word in English or other European languages, Nahol is a proper noun and the village of Nahol (bp) (नहोल (bp)) is in the Shimla District of Himachal Pradesh State, India.  In the anthropological record, it seems most often mentioned as used a name in PNG (Papua New Guinea) and East Africa although many of those texts were derived from oral histories so what was recorded as a phonetic “Nahol” may in some cases have been variants.  Whether there’s any link in origin between the uses in PNG & East Africa isn’t known and as a relatively simple (five letter, two syllable) form, it is likely Nahol came independently to be used as a name in more than one place.  The best documented origin is from Ethiopia where the name Naol often was transliterated as Nahol, Nawol or Naoll; it’s a masculine form from Oromo culture meaning “one who brings the peace” or “peaceful”. 

Nahol as a proper noun (surname): Isaac Amu Nahol.

There is an ancient linkage between Jewish traditions and Ethiopia but there’s no evidence the surname Nahols (most prevalent in Eastern Europe, notably among Jewish communities in Poland and Ukraine) has any connection with the Oromo culture; the similar form Nahal (or Nahaul) from the Hebrew (נחל) (nahal) meaning “stream, brook, valley” (and, by extension, “inheritance” (the idea of an estate “flowing” to the descendants)).  Nahols may have been derived from a Yiddish or Hebrew personal name (on the model of English names such as Stevenson (ie the son of Steven)).  In Arabic, the cognate root yielded Nahel & Nahil which although often understood as “generous” or “successful”, was linked also to “bees & honey”, the latter perhaps accounting for why one Bangladeshi (the old post-partition East Pakistan) source cited the name Nahol meaning “the queen of bees”.

Nova Sky: Yasdnil, Star Of (2021) by Yasdnil (Lindsay Ferraro).

The anadrome of “Lindsay” is “Yasdnil”.  As a surname, Yasdnil is astonishingly rare, the genealogy sites listing only a few dozen instances with the origin, although uncertain, thought to be Persian and from the Yazd region (in modern, Central Iran).  The name is thought drawn from Yas, a type of desert flower, thus the symbolic link of the name with beauty and nature.  Genealogists note the rarity and suspect at least some names with similar spellings may be variant forms.  In the Actinobacteriophage Database, Yasdnil is listed as an Actinobacteriophage (viruses that infect bacteria in the phylum Actinobacteria) found in North Texas in 2018 “…in a soil sample that was dark, dry and had organic material (wood-chips, branches etc).”  The researcher reported the phage was named after “…an individual who was important to me, a lot of time was invested into the phage just as a lot of time was invested into that individual.  Naming the phage after them seemed appropriate as it commemorates commitment and good memories.”  It wasn’t revealed whether the inspiration was a “Yasdnil” or an anadromic “Lindsay”.  Yasdnil is also used as a pseudonym (presumably usually as an anadrome of Lindsay) and the best known may be author and advocate Lindsay Ferraro, who published the poetry collection Nova Sky: Yasdnil, Star Of (2021).  Less encouragingly, NRS (normally reliable source) Urban Dictionary has a listing for yasdnil as meaning “the Devil’s daughter”.

Corona

Corona (pronounced kuh-roh-nuh)

(1) A white or colored circle or set of concentric circles of light seen around a luminous body.

(2) In meteorology, such a circle or set of circles having a small radius and ranging in color from blue inside to red outside, attributable to the diffraction caused by thin clouds, mist, or sometimes dust (distinguished from halo).

(3) In solar astronomy, a faintly luminous envelope outside of the sun's chromosphere, the inner part consisting of highly ionized elements; also called aureola & aureole.

(4) A long, straight, un-tapered cigar, rounded at the closed end.

(5) In botany, a crown-like appendage, especially one on the inner side of a corolla, as in the narcissus.

(6) In anatomy, the upper portion or crown of a part, as of the head.

(7) In architecture, the projecting, slab-like member of a classical cornice supported by the bed molding or by modillions, dentils, etc., and supporting the cymatium.

(8) The tonsure of a monk or other cleric.

(9) In ecclesiastical dress, a gold-colored stripe around the lower edge of a clerical headdress, as of a miter.

(10) A chandelier of wrought metal, having the form of one or more concentric hoops.

(11) In zoology, the head or upper surface of an animal, such as the body of an echinoid or the disc and arms of a crinoid.

(12) As Coronaviruses, a group of viruses which infect mammals and birds.  In humans, they cause usually mild (including 229E, the common cold) respiratory infections but forms such as SARS, MERS the famous COVID-19 can be lethal.

1555–1565: From the Latin corōna (garland, crown) from the Ancient Greek κορώνη (korṓnē or korōnis (crown, any curved object)), akin to korōnís (wreath; curved, beaked) & kórax (crow; raven); related was the Latin curvus (curved).  A doublet of crown, the plural forms are coronas & coronae.

COVID-19 and Coca-Cola

COVID-19 (an abbreviation of coronavirus disease 2019) was the name of the disease caused by SARS-CoV-2.  The name was adopted in February 2020, chosen by the World Health Organization (WHO) in partnership with the Committee on Taxonomy of Viruses; until then, variously it had been called 2019-nCoV, Novel coronavirus or Wuhan coronavirus.  SARS-CoV-2 is related to MERS-CoV (which causes Middle East respiratory syndrome (MERS)) and SARS-CoV (which causes severe acute respiratory syndrome (SARS)).

The Sun and its corona (left) and a depiction of the SARS-CoV-2 virus (bottom).

The class to which these viruses belong is called corona because, when viewed under an electron microscope, there’s a resemblance to the crown-like corona (the halo or ring of fire) around the Sun, seem when viewed through an appropriate telescope or other device.  The corona around the sun has long been known but viruses have been seen only since the development of the electron microscope because human viruses are very small, typically 100 nanometers (1 metre = 1,000 mm = 1,000,000 micrometres = 1,000,000,000 nanometres).  In the evolutionary timeline of life on earth, it's believed bacteria emerged quite some time before viruses.  Bacteria appear to have been one of the earliest forms of life and, because no evidence of life has yet been detected anywhere else in the universe, they're perhaps among the oldest anywhere.  Single-celled organisms with a relatively simple structure and capable of independent reproduction, bacteria are thought to have appeared some 3.5 to 3.8 billion years ago (the Earth dating back 4.5 billion) and the evidence suggests the viruses emerged 2-3 billions years ago.  Unlike bacteria, viruses are not considered living organisms in the traditional sense because they cannot carry out metabolic processes or reproduce on their own; instead, they are genetic material (DNA or RNA) enclosed in a protein coat.

As far as is known, all life forms now extant (and all extinct forms known) are descended ultimately from the one initial instance; life started once which means humans are related to cats, dogs, trees & bananas as well as to bacteria & viruses.  That makes people, bacteria and just about everything else vulnerable to infection by one virus or another, the consequences ranging from nothing to death but the behavior can also be used to advantage and a certain class of virus, the bacteriophage, after a long period of neglect during the antibiotic era, is attracting new interest.

Some viruses can be helpful: A depiction of bacteriophages phaging.

Not all viruses are bad like SARS-CoV-2.  A bacteriophage, known almost always as a phage, is a virus which infects and replicates within bacteria.  Phages are composites of proteins that surround a DNA or RNA genome and may encode any number of genes from a handful to many hundreds.  Phages replicate within the bacterium following the injection of their genome into the target cytoplasm.  Phages exist naturally in the environment and are among the most common and diverse entities on earth.  Serious research began in several parts of Europe during the late nineteenth century and have been used for almost a century as anti-bacterial agents the former USSR and Central Europe.  In the West, phage therapy (using specific viruses to fight difficult bacterial infections) has been of interest for some time, attention heightened as the problem of antibiotic-resistant bacteria (superbugs in the popular imagination) began to grow in severity (the US Centers for Disease Control and Prevention (CDC) attributes one death every 15 minutes in the US to superbugs).  Since the discovery of penicillin, antibiotics have been used as a reliable cure for those suffering from once lethal bacterial infections but, over decades, a handful (compared with the trillions and trillions killed) of bacteria have proved resistant to antibiotics and as these survivors multiply, new infections emerge.  Historically this had prompted the development of revised or new antibiotics but the biological arms race has reached the point where some infections caused by called antibiotic resistant bacteria cannot be treated and for many other serious infections, the number of potent “last resort” antibiotics is dwindling.

Hence the interest in phages, a type of “friendly virus” which can be weaponized to fight even the most virulent and persistent bacterial infections.  Phages work as well as they do because viruses like the tiresome SARS-Cov-2 that makes humans sick, phages can infect only bacteria and are selective about which they target, a vital aspect of their role in medicine because human survival depends on the billions of bacteria in our bodies.  These phages are far from rare, existing in the natural environment almost everywhere on the planet and scientists conducting research find dirty waterways or damp, aerated, warm, decaying soil (both areas where high bacterial growth might be expected) are good places to collect samples.  The advantages phages offer are well known but there are also drawbacks and indeed some of the features of phages manifest as both.  For example, the great specificity of phages helpful in that they can be administered safely with the knowledge that no other organisms will be harmed but this can be a practical disadvantage in clinical medicine when it’s not known exactly which bacteria need to be targeted, which is why broad-spectrum antibiotics proved so effective at scale.  Being wholly natural, the shelf-life of phages is highly variable and there’s little experience in their administration beyond some communities in Eastern Europe where they’ve been part of medical practice for over a century.  Additionally, bacteria can develop resistance even to phages and one practical impediment to deployment not well recognized until recent years is that compared to chemical molecules, phages are quite big and there are sites in the human body which will be inaccessible.

Electron micrograph of a Coronaviruses in colorized and in grey-scale.

The images captured from electron microscopes are always in black-and-white but are often artificially colored in the post-production process for better visualization and to assist with analysis.  Because of the resolution limit of the optical microscope, even at the highest magnification, viruses couldn’t be seen because their size meant they lay beyond the spectrum of visible light, the range of resolution being limited by the wavelength of the visible light that illuminates the specimen.  It was the resolution of the electron microscope, developed in the early 1930s, and able to offer an illumination with a wavelength much smaller than visible light which first made viruses visible.  An electron has the properties both of a particle and a wave so an electron’s wavelength is determined by its energy (or speed).  If an electron is accelerated to a speed of a million meters per second (circa 2.2 million mph (3.5 million km/h)) the physical wavelength is around one-tenth of a nanometer or about the size of an atom.  This permits an electron microscope to probe the structure of atoms in a crystal and thus see viruses.

Lindsay Lohan taking a 330ml lunch.

In February 2021, at a time when the official number of people with COVID-19 was around 107 million, mathematicians calculated all the COVID-19 causing SARS-COV-2 virus then circulating the planet easily would fit in a single (330ml) Coca-Cola can.  Using a model based on the viral load per currently infected victim (which varies during the duration of the infection), it was estimated there were at the time around two-hundred quadrillion (200 million billion or 2x10¹⁷). SARS-CoV-2 virus particles in the world.  Using that number, knowing the size of the virus, it was possible to calculate the total volume and even after accounting for the distinctive projecting spike proteins meaning the spherical particles will leave gaps when stacked together, the total is still less than the internal volume of the 330 millilitre can.

Two-hundred quadrillion is a really big number, there are said to be about that many grains of sand on the planet, but Sars-CoV-2 particles are really small, around a hundred nanometres (one nanometre is a billionth of a meter) so the radius of Sars-CoV-2 is roughly a thousand times thinner than a human hair.  The mathematicians multiplied the numbers, worked out the wastage of space caused by the troublesome spikes accounted for about a quarter of the total volume and concluded that in February 2021, the volume of SARS-CoV-2 in the world was 160 millilitres.  By mid-2021, cases had almost doubled so by then, either the can would be full or, given the margin of error associated with such calculations, a second can might be required.  The caveat to all this is that the math is based on the official number of infected people and nobody knows what the real is although all agree it will be higher but by what factor is guesswork, reliable data just not available to build a model.  Guesses have been proffered ranged from double to twenty times higher.  Depending on which of those is closest, a six-pack or a carton of cans might be filled.

Rare collector’s item: Lindsay Lohan MH Corona Extra tobacco card #480: US$5.00 on eBay.  Unrelated to this card is the specification of the corona cigars, straight-shaped cigars with rounded tops (the end taken to the lips) and defined by length: a corona about 5½ inches (140 mm) long; a petit corona (or corona chica) about 5 inches (125 mm) long, a tres petit corona about 4½ inches (115 mm) long & a half corona about 3¾ (95 mm) inches long.

The Toyota (Corona) 1600GT

1958 Toyota Corona "Van".

It was the Toyota Corona (1957-2001) which not only established the company in the vital US market but lent respectability to the very idea of the “Japanese car”, that term in the early 1960s not the by-word for quality and reliability it would in subsequent decades become.  Noting the success of the small (by US standards) Volkswagen Beetle and other imports, the company shipped a small number of Coronas to the US in the late 1950s but they were unsuitable for the environment (as indeed were a number of the diminutive European models which lacked the ruggedness of the VW) and interest was minimal, the Corona withdrawn from sale in 1960 although unsold models lingered on the lots for another year.

1966 "shovel-nose" Toyota Corona.

It was the third generation Corona, launched in September 1964 in an array of body styles, which was the Toyota passenger car to achieve international success, including in the US.  It was a thoroughly conventional design (ie mechanically a scaled down US sedan) with a body which was modern, inoffensive and practical although some thought the reverse-slanted nose strange.  It came to be nick-named the “shovel-nose” and proved ahead of its time, adopted in 1972 by Lancia for the Beta and in 1976 it appeared on Ford’s Escort RS2000 before variations of the shape eventually became the default for manufacturers seeking to eke out as much aerodynamic efficiency as possible.

The "shovel-nose" caught on: 1972 Lancia Beta (left) & 1976 Ford Escort RS2000 (right).  

The export range appeared in volume but the most desirable models were reserved for the JDM (Japanese domestic market), a long-standing, industry-wide practice which has had the effect of creating a minor export business for those who can satisfy the demand in markets like Australia, New Zealand & North America for the high-performance versions which have something of a cult-following.  The 1967 1600GT (or GT-5 for those with the optional five-speed gearbox) coupé (for this JDM “halo” model the Corona badge wasn’t used) was modest compared with some of the wild machinery which would appear in subsequent decades but by the standards of its time, there was some genuine sophistication.  The body was the standard two-door hardtop but the centrepiece was a double overhead camshaft (DOHC) cylinder head atop the 1600 cm³ four cylinder engine, the head designed by Yamaha which had also developed the one used on the straight-six in the exotic Toyota 2000 GT sports car made famous by the appearance of a custom built roadster version in the James Bond film You Only Live Twice (1967).

1967 Toyota 2000GT roadster.  Two 2000GT coupés were converted into roadsters for You Only Live Twice (one used for filming, the other a "back-up"), the work undertaken by Toyota’s special Toyopet Service Centre in Tsunashima.  The wire wheels were exclusive to the roadsters (15×5 inch magnesium wheels were used on the coupés) and the pair were very much movie props, neither vehicle fitted with side windows or a soft-top.  The "back-up car" is now on display in the Toyota Automobile Museum.

Known internally as the 9R, the 1600GT engine took a traditionally English approach to increasing power: twin carburetors, big valves and a high-compression ratio, the combination yielding a then impressive 110 horsepower at 6200rpm, the latter number something to note given the crankshaft was supported by only three main bearings.  Still, being a Toyota engine, reliability was solid and no history of bottom-end failure emerged; whether the unusual firing order (1243) had anything to do with this seems not to be discussed anywhere.  To cope with the new-found power, the Corona’s suspension was strengthened with re-calibrated springs and dampers along with two torque rods to locate the back axle.  That improved things but the Japanese manufacturers, although matching the Europeans in power, still had some way to go in achieving their dynamics; the 1600 GT was no cut-price Alfa Romeo.  It was though very well equipped, another lesson Toyota and other Japanese factories would (painfully) teach the West.  Always a low volume model, production of 1600 GTs totalled 2222, the last built late in 1968.

1967 Toyota 1600GT.  They were available also in red and white.

1974 Toyota Corona advertising.

The 1600GT's cult following notwithstanding, it really wasn't representative of the Coronas which went around the world and for decades provided owners and fleets with reliable, if uninspiring transport (very much the Camry of their time).  That made them memorable for many who may have enjoyed the charms of British, French or Italian machinery but found the quirks, oil-leaks, fragility or apparently insoluble issues electrical issues (often described as "gremlins") made ownership tiresome.  Toyota were aware of the advantage their approach (which put a premium on basic engineering and quality control over the finer points of handling and high-speed braking) and their advertising for the Corona in the 1970s said explicitly: "When your heart says Europe but your head says Japan".  People increasingly followed their heads and by 1989 Toyota released the Lexus, proving they were as good at building a Mercedes-Benz as they were at building Toyotas.  It took many attempts for Mercedes-Benz to become (almost) as good at building Toyotas.

Phage

Phage (pronounced feyj)

In microbiology & virology, a virus parasitic towards bacteria; a truncation of bacteriophage.

1917: from the Ancient Greek φάγος (phágos) (eater), from φαγ (phag), aorist (the tense of Greek verbs that most closely corresponds to the simple past in English) stem of ἐσθίω (esthíō) & ἔδω (édō) (to eat, to consume) and thus a combining form meaning “a thing that devours,” used in the formation of compound words, especially the names of phagocytes.  The noun bacteriophage (virus that parasitizes a bacterium by infecting it and reproducing inside it) was adopted in English in 1921, from the 1917 French original bactériophage, the construct being bacterio- (a combining form of bacteria) + -phage.

Some viruses can be helpful: A depiction of phages phaging.

Not all viruses are bad like SARS-CoV-2.  A bacteriophage, known almost always as a phage, is a virus which infects and replicates within bacteria.  Phages are composites of proteins that surround a DNA or RNA genome and may encode any number of genes from a handful to many hundreds.  Phages replicate within the bacterium following the injection of their genome into the target cytoplasm.  Phages exist naturally in the environment and are among the most common and diverse entities on earth.  Serious research began in several parts of Europe during the late nineteenth century and have been used for almost a century as anti-bacterial agents the former USSR and Central Europe.  In the West, phage therapy (using specific viruses to fight difficult bacterial infections) has been of interest for some time, attention heightened as the problem of antibiotic-resistant bacteria (superbugs in the popular imagination) began to grow in severity (the US CDC (Centers for Disease Control and Prevention) attributes one death every 15 minutes in the US to superbugs).  Since the discovery of penicillin, antibiotics have been used as a reliable cure for those suffering from once lethal bacterial infections but, over decades, a handful (compared with the trillions and trillions killed) of bacteria have proved resistant to antibiotics and as these survivors multiply, new infections emerge.  Historically this had prompted the development of revised or new antibiotics but the biological arms race has reached the point where some infections caused by called antibiotic resistant bacteria cannot be treated and for many other serious infections, the number of potent “last resort” antibiotics is dwindling.

Hence the interest in phages, a type of “friendly virus” which can be weaponized to fight even the most virulent and persistent bacterial infections.  Phages work as well as they do because viruses like the tiresome SARS-Cov-2 that makes humans sick, phages can infect only bacteria and are selective about which they target, a vital aspect of their role in medicine because human survival depends on the billions of bacteria in our bodies.  These phages are far from rare, existing in the natural environment almost everywhere on the planet and scientists conducting research find dirty waterways or damp, aerated, warm, decaying soil (both areas where high bacterial growth might be expected) are good places to collect samples.  The advantages phages offer are well known but there are also drawbacks and indeed some of the features of phages manifest as both.  For example, the great specificity of phages helpful in that they can be administered safely with the knowledge that no other organisms will be harmed but this can be a practical disadvantage in clinical medicine when it’s not known exactly which bacteria need to be targeted, which is why broad-spectrum antibiotics proved so effective at scale.  Being wholly natural, the shelf-life of phages is highly variable and there’s little experience in their administration beyond some communities in Eastern Europe where they’ve been part of medical practice for over a century.  Additionally, bacteria can develop resistance even to phages and one practical impediment to deployment not well recognized until recent years is that compared to chemical molecules, phages are quite big and there are sites in the human body which will be inaccessible.

However, looming over the treatment of bacteriological infection is the economics of the pharmaceutical business (big-pharma).  It was the ability in the twentieth century of the industry to mass-produce antibiotics at scale and at astonishingly low cost which meant what little research on phages was being undertaken quickly was abandoned; antibiotics truly were miracle drugs.  However, the economics which made antibiotics attractive to the public health community meant they added comparatively little to the profits of big-pharma compared with something lucrative like a blood-pressure drug which a patient would be required to take every day for the rest of their lives.  A cheap antibiotic, needed disproportionately in low-income countries was a less attractive path for the billions of dollars (and usually years of trials) required to bring a new drug to market.  What the industry likes are drugs which can be mass-produced to treat the “curse of plenty” diseases of first world customers.  Unless there’s some sort of molecular breakthrough (presumably at the level of DNA), phages seem likely for the foreseeable future to remain a niche treatment.

Little killing machines: Matt Cirigliano's graphical depiction of phages in action.

Potential phage research subject: In 2014, while on holiday in French Polynesia, Lindsay Lohan was infected with Chikungunya, a virus (CHIKV) spread by the bites of infected (usually the Aedes) mosquitoes; it causes severe joint pain, headache, fever, nausea, fatigue and rash and flu-like symptoms but can occasionally be fatal.  The word Chikungunya from the Kimakonde language and translates literally as "to become contorted"; the condition was first isolated in Tanzania in 1952 before spreading around the Indian Ocean region, south-east Asia and the Pacific islands, cases emerging for the first time in the Caribbean in 2013 while until recently, it was rare in the US and Europe, most victims having traveled from affected areas.  There is no cure or vaccine, and the illness can last from several days to as long as a few weeks.  Ms Lohan advised those in susceptible regions to use bug spray and posted on Instagram a photo from the beach, captioned "I refuse to let a virus effect (sic) my peaceful vacation."

In August 2025, wire services began reporting Sri Lanka was facing its worst Chikungunya outbreak in two decades, public health experts linking the spread (the virus since earlier in the year widespread in southern China) to climate change, mosquito habitats spreading as weather patterns shift.  In Beijing, despite Chikungunya not being spread by human-to-human contact, the ruling CCP (Chinese Communist Party) ordered mass quarantines with the southern province of Guangdong thought worst afflicted.  With the CCP having perfected the protocols established during the Covid-19 pandemic, infected residents were confined to “quarantine wards” in hospitals and placed in beds covered by mosquito nets; unless testing negative, there they must remain for seven days.  The CCP is applying technology to the problem, swarms of drones being deployed spraying insecticide, the missions said to be both “targeted” (ie the drone’s sensors being used by an on-board AI (artificial intelligence) engine to detect possible mosquito breeding areas) and “carpeting” (ie soaking a defined area in a way analogous to the “carpet bombing” (also as “area bombing”) of cities which was one of the more controversial strategies of World War II (1939-1945).

Chikungunya virus (CHIKV) assembly and egress.

Biological warfare is also being pursued: (1) millions of non-transmissive “elephant mosquitoes” being released, their larvae devouring the smaller, virus-carrying pests and (2) thousands of mosquito-eating fish being placed in public ponds.  Once the Aedes mosquito becomes endemic to an area, it’s reproduction can be difficult to restrict, one Chinese public health specialist confirming breeding was possible in as small a quantity of liquid as that which might accumulate in an upturned bottle cap.  In Guangdong, representatives of the CCP vowed to take “decisive and forceful measures” with residents ordered to remove stagnant water (threats of fines up to US$1,400 a nudge towards compliance).  As well as a north-south thing, climate change is also an east-west phenomenon and disease transmission vectors can travel with weather patterns, the ECDC (European Center for Disease Prevention and Control) in July reporting some quarter-million cases with 90 confirmed deaths.  The US CDC in August issued a Level 2 travel notice (practice enhanced precautions) for those going to China, two notches down for Leve 4 (avoid all travel to the region).