Plethora & Plethoric

Plethora (pronounced pleth-er-uh)

(1) Superfluity or excess; an overabundance.

(2) A large quantity or wide array; a great abundance.

(3) In re-modern medicine, , a morbid condition due to excess of red corpuscles in the blood or increase in the quantity of blood (archaic except for historic references); an excess of any of the body’s fluids (archaic).  Medieval apothecaries offered plethora of potions and concoctions to treat “redd face”.

(4) In modern pathology, an excess of Excess of blood in the skin, especially in the face and especially chronically.

1535-1545: From the Medieval Latin plēthōra, from the Ancient Greek plēthṓra or plēthōrē or plēthṓra (fullness; satiety) from plēthein (to be or grow full), from the primitive Indo-European pele (to fill).  The original use of the word was in medicine; later adopted by pre-modern pathology to describe a specific condition.  The modern, figurative meaning (too-muchness, overfullness) was in use by the early eighteenth century.  In figurative use the synonyms include excess, abundance, glut, myriad, surfeit, superfluity & slew while in medical use they’re hyperaemia & hyperperfusion.  The non clinical description of the apothecaries redd face include flushing, blushing, floridity & ruddiness (the condition rosacea (a chronic condition characterized by redness of the face) is treatable but incurable).  Plethoric is the adjective, plethorically the adverb.  Plethora is a noun; the noun plural is plethorae or plethoras.

Lindsay Lohan and her lawyer in court, Los Angeles, December 2011.

Plethoric (pronounced ple-thawr-ik, ple-thor-ik or pleth-uh-rik)

(1) In speech or text, overfull; turgid; inflated; pompous.

(2) By extension, excessive, overabundant, rife; loosely, abundant, varied.

(3) In medicine, a patient suffering from plethora (ruddy in complexion, congested or swollen with blood).

(4) In medicine, of, relating to, or characterized by plethora.

1610–1620: From the Late Latin plethoricus, from the Hellenistic Ancient Greek πληθωρικός (plēthōrikós), from πληθώρα (plēthṓra) (plethora); It deconstructs as plethor(a) +‎ -ic.  The -ic suffix was from the Middle English -ik, from the Old French -ique, from the Latin -icus, from the primitive Indo-European -kos & -ḱos, formed with the i-stem suffix -i- and the adjectival suffix -kos & -ḱos.  The form existed also in the Ancient Greek as -ικός (-ikós), in Sanskrit as -इक (-ika) and the Old Church Slavonic as -ъкъ (-ŭkŭ); A doublet of -y.  In European languages, adding -kos to noun stems carried the meaning "characteristic of, like, typical, pertaining to" while on adjectival stems it acted emphatically; in English it's always been used to form adjectives from nouns with the meaning “of or pertaining to”.  A precise technical use exists in physical chemistry where it's used to denote certain chemical compounds in which a specified chemical element has a higher oxidation number than in the equivalent compound whose name ends in the suffix -ous; (eg sulphuric acid (H₂SO₄) has more oxygen atoms per molecule than sulphurous acid (H₂SO₃).  The use in medicine dates from the fourteenth century while the figurative senses (Excessive, overabundant, rife; loosely, abundant) in rhetoric (and later just about anything) emerged gradually after the seventeenth.  Plethoric is an adjective and plethorically is an adverb.

The apothecaries redd face

From Antiquity, through the medieval period and until as recently as some 200 years ago, it was medical orthodoxy that the plethoric (the primary symptom being a chronic reddishness of the face) was caused by an excess of the humor of yellow bile (xanthe chole).  Humoral (humor a translation of the Ancient Greek χυμός (chymos (literally juice or sap, figuratively flavor)) theory (known also as humorism or humoralism), was a system of medicine from Antiquity which provided a framework and description of the supposed workings of the human body.  It was the standard model for the philosophers and physicians of Ancient Greek and Rome and endured in Western medicine well into the nineteenth century when many of its assumptions about physical illness were disproved by germ theory and the understanding of the role of pathogens in disease.  The overturning of humoral theory was one of the landmarks in the origins of modernity.

In antiquity it was a concept rather than something with a standardized systemization and there existed competing models with more or fewer components but it’s because the description with four was that endorsed by the Greek physician Hippocrates (circa 460–circa 370 BC) that it became famous in the West and absorbed into medical practice.  The four humors of Hippocratic medicine are black bile (μέλαινα χολή (melaina chole)), yellow bile (ξανθη χολή (xanthe chole)), phlegm (φλέγμα (phlegma)) & blood (αἷμα (haima)), each corresponding with the four temperaments of man and linked also to the four seasons: yellow bile=summer, black bile=autumn, phlegm=winter & blood=spring.  In Hippocratic medicine, to be healthy, the four humors needed to be in balance and this, once achieved, was the state of enkrateia (from the Ancient Greek ἐγκράτεια (eukrasia) (in power), the construct being ἐν (en-) (in-) + κράτος (krátos) (power), a word which appears in the New Testament in the context of virtues (Acts 24:25, Galatians 5:23 & 2 Peter 1:6).  In the King James Version (KJV, 1611), it would be translated as "temperance", a word which went on to assume a life of its own.

Medieval apothecaries treated redness in the face (which may have been rosacea, sunburn, or a variety of internal or skin conditions) using a number of remedies based either on herbal medicine or humoral theory.  Some would to some extent have been have been efficacious, some worthless and some genuinely dangerous.  They included:

Herbal Remedies: (1) Rose water was frequently used both for it cooling and anti-inflammatory properties (applied directly to the skin to soothe redness and irritation), (2) Chamomile (one of medicine’s most ancient calmatives) was applied as a poultice or used in a wash to reduce inflammation and redness, (3) the flesh of the Aloe Vera plant was renowned for its soothing effect and was used to treat various skin conditions, including redness (it’s now recommended also as an alternative to shampoo and conditioner) and (4) cucumber was made into a topical paste and applied directly to the affected skin.

Cooling Agents: Diluted vinegar, often mixed with herbs, was applied to cool the skin and reduce redness. This was believed to balance the body's humors, particularly if the redness was thought to be caused by an excess of heat (choleric humor).

Minerals: (1) In severe or intractable cases (as chronic rosacea tends to be), Ceruse (white lead) was sometimes used to whiten and cover red or blemished skin (a treatment which would be though dangerous by modern standards) and (2) Calamine (a mineral compound) was used to treat skin irritation and reduce redness.  Calamine lotion remains one of the most effective treatments for minor skin irritations.

Humoral Treatments: (1) Until quite recently, it was common for skin redness (especially in the face) to be caused by an imbalance in the body's humors, especially an excess of blood (sanguine humor).  Phlebotomy (bloodletting) was often performed and there were specialists who practiced the trade exclusively (in the USSR (the old Soviet Union) it was still an orthodox treatment as recently as the 1950s, even comrade Stalin (1878-1953; Soviet leader 1924-1953) enjoying some sessions.  (2) Presumably as a result of empirical observation, a patient diet was identified as a contributory factor and the apothecaries followed the practice of the physicians from Antiquity, advising sufferers to eat “cooling foods” like cucumbers, lettuce, and melons, while avoiding “heating foods” such as spicy dishes and red meat.

Spectrum condition: The redness in the face of the honourable Barnaby Joyce (b 1967; thrice (between local difficulties) deputy prime minister of Australia 2016-2022) is used by his colleagues to gauge where his state of mind lies in the adjectival progression of the plethoric (left), the more plethoric (comparative; centre) and the most plethoric (superlative; right).  Mr Joyce’s symptoms (ambitious, leader-like, restless, easily angered) suggest an excess of yellow bile and to counteract this, Hippocrates recommended cold and wet foods such as cucumber or lettuce to bring the humors back into alignment.  Mr Joyce should adopt a cucumber & lettuce diet and it may be a good time for him to try it because he recently announced he'd given up alcohol, the abstinence inspired by a recent "incident" in which he was filmed lying drunk on the footpath (sidewalk) next to a Canberra planter box, conducting a mumbled, expletive-laden conversation with his wife.  He said he's since lost 15 kg (33 lb) and given up smoking (it not known if politicians lie about such claims).  Interestingly, political scientists seem generally to expect the well-publicized event (one of a number featuring Mr Joyce) would probably result in him increasing his margin at the next election (sprawled drunk in a city street making him "authentic" and "relatable").  When interviewed, the once "notorious drunkard" said: "Maybe at some stage I’ll have a beer again, but at the moment, nah".

Reprobate

Reprobate (pronounced rep-ruh-beyt)

(1) A depraved, unprincipled, or wicked person; degenerate; morally bankrupt.

(2) In Christianity (from Calvinism), a person rejected by God and beyond hope of salvation and damned to eternal punishment in hell, forever hearing only their own screams of agony, smelling only their own decaying flesh and knowing only the gnashing of their decaying teeth.

(3) Rejected; cast off as worthless (archaic).

1400-1450: From the late Middle English reprobaten (condemn, disapprove vehemently; rejected as worthless) from the Latin reprobātus (disapproved, rejected, condemned), past participle of reprobāre (to reprove or hold in disfavour).  The construct was re- (back, again (here indicating probably "opposite of, reversal of previous condition")) + probare (prove to be worthy).  Used often in the form reprobacioun (rejection), the usual spelling in Church Latin was reprobationem (nominative reprobation (rejection, reprobation), the noun of action from the past-participle stem of reprobāre.  A doublet of reprove.

Notorious dispensationalist and reprobate, crooked Hillary Clinton in pantsuit.

The earliest use in English was as a verb meaning "to disapprove”; the specific religious meanings were adopted in the mid-fifteenth century, the general sense of an unprincipled person emerging decades later.  The sense of "reject, put away, set aside" dates from circa 1600 and the meaning "abandoned in character, morally depraved, unprincipled" is attested from the 1650s.  The specifically religious idea of "one rejected by God, person given over to sin, from the adjectival sense was from the 1540s whereas the generalized "abandoned or unprincipled person" was noted from the 1590s.  The use in theology was more specialised still.  The meaning "the state of being consigned to eternal punishment" was used since the 1530s and from the 1580s, this extended to any "condemnation as worthless or spurious" the more broad sense of "condemnation, censure, act of vehemently disapproving" used since 1727.  Other nouns once used in English include reprobacy (1590s), reprobance (c. 1600), reprobature (1680s, legal); never common, most are now archaic except a technical, historic terms.  Although the word has many synonyms (tramp, scoundrel, wastrel, miscreant, wretch, rascal, cad, rogue, outcast, pariah, wicked, sinful, evil, corrupt) it has always attracted authors who enjoy detailing the reprobacy of the habitually reprobative.

You are a heartless reprobate, sir; a heartless, thankless, good-for-nothing reprobate.  I have done with you.  You are my son; that I cannot help - but you shall have no more part or parcel in me as my child, nor I in you as your father.

Anthony Trollope (1815-1882), Barchester Towers (1857)

The fate of all reprobates.  The Harrowing of Hell (c 1499), by Hieronymus Bosch (1450–1516)

Christians are much concerned with the fate of reprobates, all of whom should be condemned.  Israel Folau (b 1989), a Tongan-born Australian football player (of the country’s three oval-ball codes) however attracted some condemnation himself when he posted on Instagram: “Warning – Drunks, Homosexuals, Adulterers, Liars, Fornicators, Thieves, Atheists, Idolaters. HELL AWAITS YOU. REPENT! ONLY JESUS SAVES”.  There were many who rose to defend the homosexuals but all seemed oblivious to the feelings of the others on his list, the chattering classes content to let drunks, adulterers, liars, fornicators, thieves, atheists and idolaters rot in Hell.  Noted drinker and adulterer Barnaby Joyce (b 1967; thrice (between local difficulties) deputy prime minister of Australia 2016-2022) must have felt put-upon. 

Some have been more expansive on the matter of reprobates than Mr Folau, Loren Rosson on his Busybody page detailing in three tiers, the worst of the sins committed by man, according to Pastor Steven Anderson (b 1981), preacher & founder of the New Independent Fundamentalist Baptist movement and pastor of Faithful Word Baptist Church, Tempe, Arizona.  Anderson first came to national attention in August 2009 after preaching a sermon in which he prayed for the visitation of the Angel of Death to Barack Obama (b 1961; US president 2009-2017).  In what he may suspect is a a conspiracy between the Freemasons and the Jews, Anderson has been denied entry to South Africa, Botswana, Jamaica, Canada, the United Kingdom, the European Union, the Republic of Ireland, Australia and New Zealand.

Tier 1: The irrevocably damned. Those beyond redemption, God having rejected them eternally.

(1) Homosexuals/pedophiles.  Note the absent ampersand; in Anderson’s view the two are inseparable, it being impossible to be one without being the other; they are the worst of the worst.  Anderson believes sodomites are not only sinners, but actual reprobates, based on the Book of Romans, God having tired of them, he turned them into sodomising perverts:  “God gave them up to vile affections” (Romans 1:26); “God gave them over to a reprobate mind” (Romans 1:28); “God gave them up to uncleanness through the lusts of their own hearts” (Romans1:24).  This, Anderson argues, is the explanation for homosexuality and surprisingly he’s in agreement with the gay view that “God made me like this” though not “born like this” faction, God making them that way only when they rejected the truth and the light; God “discarding them by turning them into homos.”  As reprobates, sodomites, unlike most sinners (those in tiers 2 and 3), cannot possibly be saved, nor should anyone want to try saving them: “He that is filthy, let him be filthy still” (Revelation 22:11).  The internal logic is perfect, God turned them into sodomites because of their God-hating hearts and it’s all their fault.

(2) Bible translators and scholars.  Anderson condemns these folk as irredeemable reprobates because of the Revelation 22:19, which damns all who tamper with the Word of God, ie altering the original text of the King James Bible (KJV 1611).

Tier 2: Especially wicked sinners:  These offenders are at least capable of being saved, if they accept Christ the Lord as their savior.

(3) Physicians who perform abortions, pro-choice crusaders; women who obtain abortions.  Anderson’s view is that all those involved in the abortion industry, the medical staff, the proponents and the women who procure the operation are simply those who murder the most innocent and vulnerable; they are reprobates. 

(4) Zionists.  Israel is the most ungodly nation on the planet according to Anderson and he calls the formation of the state of Israel in 1948 a diabolical fraud.  The Jews are not God’s chosen people and have not been so for two millennia, replacement theology a basic premise of the New Testament: “If the kingdom of God is taken from you and given to a nation bringing forth the fruits thereof, you’ve been replaced! You were the people of God, you were that holy nation of the Old Testament, but now you have been replaced. And today, the physical nation of Israel has been replaced by believers, by a holy nation made up of all believers in Christ, whether they be Jew or Gentile, no matter what the nationality.” According to Anderson, Zionism is more anti-Christ than any other of the major world religions.

(5) Modalists.  Anderson hates and despises modalists more even that the atheists who deny the very holiness of Christ.  Modalism is a heresy that denies the trinity and maintains God is only one person or entity (there are factions) who has three modes (or faces, or masks) which do not exist simultaneously, and that He changes modes by assuming whatever mode circumstances demand.  Thus to modalists, the Father, the Son, and the Holy Spirit are all the same person or entity, there not being the three in one but just one who shifts modalities as required.  This is of course heresy because Christianity teaches the Father, the Son, and the Holy Spirit are distinct. There is of course but one God but within God there are three entities which Christians call trinity.

(6) Atheists & evolutionists.  It’s not entirely clear if Anderson regards these two as interchangeable but it’s probably a tiresome technical point, both equally at risk of becoming reprobates who, if they persist in their rejection, God will turn into sodomites.

(7) Litterbugs.  Anderson might find some sympathy for this category.  Anderson hates those who drop litter whether on city streets or in the wilderness and can quote scripture to prove God too disapproves.

(8). Men who piss sitting down.  Anderson identifies this sin as one especially prevalent among Germans and other secular Europeans but any man who allows himself to be pussy-whipped into effeminate behavior in the loo is suspect.  Although among the less well-known passages in the Bible (KJV; 1611), “him that pisseth against the wall” (1 Samuel 25:22; 1 Samuel 25:34; 1 Kings 14:10; 1 Kings 16:11; 1 Kings 21:21; 2 Kings 9:8), it's known to Anderson who cites as a symbol of proper manliness.  However, the original translators may have been a little more nuanced, scholarship suggesting it’s best understood as “able-bodied men”.  Anderson condemns preachers, presidents & potentates who “pee sitting down” and demands leadership of the country be restored to those “who want stand up and piss against the wall like a real man.”  Anderson assures his congregation he’s a "stand and piss man".  For men wishing to score points with God and obtain redemption, this is one of the sins most easily forever renounced.  However, don’t lie, for God knows how you pee.

(9) Physicians and technicians who perform in vitro fertilization; women who undergo the treatment.  Anderson explains those who conceive using IVF instead of waiting naturally to fall pregnant are stealing babies from God, a concept he expresses more graphically in sermons as “ripping babies from the hands of God”.

(10) Male gynecologists.  Anderson says men who do this are disgusting perverts; their medical qualifications are irrelevant

Tier 3:  Sinful Christians. Those who preach or espouse these views could either be false Christians, or simply misguided believers in Christ who need to be educated.

(11) Pre-tribbers.  Anderson is actually on sound historical and theological ground here.  The idea that Christians will, on the day of the rapture, be taken bodily up to heaven before the apocalyptic tribulation is a wholly un–biblical notion unknown before the mid-nineteenth century and barely known before being spread in pop-culture.  It seems to have begun as a way of marketing Christianity as something more attractive.  As the Book of Revelation makes clear, Christians not only expected to suffer the tribulation before they were raptured, that suffering lies at the core of their holy duty.  Pre-tribulation is an un-Christian cop-out.

(12) Dispensationalists. Anderson is also correct that dispensationalist is another nineteenth century heresy and a kind of cultural relativism and while he doesn’t dwell on it, thinks cultural relativists are among the worst reprobates).  Anderson asserts that God never changes, noting “Jesus Christ the same yesterday, today, and forever” (Hebrews 13:8).  The Old Testament carries the same moral imperatives it always did, and the God of the New Testament aligns completely with it.

(13)  Calvinists, and others who deny free will.  It matters not to Anderson whether one cites a theological or biological basis for rejecting the doctrine of man’s free will; both are wrong.

(14) The lazy box-tickers. It’s not enough just occasionally to walk the neighborhood streets and leave in the mailboxes a flyer about Jesus, at least twice a week a Christian must go about their district, knocking on doors and spreading the word of the Lord.

US screenwriter & film director Paul Schrader (b 1946) really knows how to hurt someone's feelings.

Mutation

Mutation (pronounced myoo-tey-shuhn)

(1) In biology (also as “break”), a sudden departure from the parent type in one or more heritable characteristics, caused by a change in a gene or a chromosome.

(2) In biology, (also as “sport”), an individual, species, or the like, resulting from such a departure.

(3) The act or process of mutating; change; alteration.

(4) A resultant change or alteration, as in form or nature.

(5) In phonetics (in or of Germanic languages), the umlaut (the assimilatory process whereby a vowel is pronounced more like a following vocoid that is separated by one or more consonants).

(6) In structural linguistics (in or of Celtic languages), syntactically determined morphophonemic phenomena that affect initial sounds of words (the phonetic change in certain initial consonants caused by a preceding word).

(7) An alternative word for “mutant”

(8) In cellular biology & genetics, a change in the chromosomes or genes of a cell which, if occurring in the gametes, can affect the structure and development of all or some of any resultant off-spring; any heritable change of the base-pair sequence of genetic material.

(9) A physical characteristic of an individual resulting from this type of chromosomal change.

(10) In law, the transfer of title of an asset in a register.

(11) In ornithology, one of the collective nouns for the thrush (the more common forms being “hermitage” & “rash”)

1325–1375: From the Middle English mutacioun & mutacion (action or process of changing), from the thirteenth century Old French mutacion and directly from the Latin mūtātion- (stem of mūtātiō) (a changing, alteration, a turn for the worse), noun of action from past-participle stem of mutare (to change), from the primitive Indo-European root mei- (to change, go, move).  The construct can thus be understood as mutat(e) +ion.  Dating from 1818, the verb mutate (to change state or condition, undergo change) was a back-formation from mutation.  It was first used in genetics to mean “undergo mutation” in 1913.  The –ion suffix was from the Middle English -ioun, from the Old French -ion, from the Latin -iō (genitive -iōnis).  It was appended to a perfect passive participle to form a noun of action or process, or the result of an action or process. The use in genetics in the sense of “process whereby heritable changes in DNA arise” dates from 1894 (although the term "DNA" (deoxyribonucleic acid) wasn't used until 1938 the existence of the structure (though not its structural detail) was fist documented in 1869 after the identification of nuclein).  In linguistics, the term “i-mutation” was first used in 1874, following the earlier German form “i-umlaut”, the equivalent in English being “mutation”.  The noun mutagen (agent that causes mutation) was coined in 1946, the construct being muta(tion) + -gen.  The –gen suffix was from the French -gène, from the Ancient Greek -γενής (-genḗs).  It was appended to create a word meaning “a producer of something, or an agent in the production of something” and is familiar in the names of the chemical elements hydrogen, nitrogen, and oxygen.  From mutagen came the derive forms mutagenic, mutagenesis & mutagenize.  Mutation, mutationist & mutationism is a noun, mutability is a noun, mutable & mutant are nouns & adjectives, mutated & mutating are verbs & adjectives, mutational & mutationistic are adjective and mutationally is an adverb; the noun plural is mutations.  For whatever reasons, the adverb mutationistically seems not to exist.

In scientific use the standard abbreviation is mutat and forms such as nonmutation, remutation & unmutational (used both hyphenated and not) are created as required and there is even demutation (used in computer modeling).  In technical use, the number of derived forms is vast, some of which seem to enjoy some functional overlap although in fields like genetics and cellular biology, the need for distinction between fine details of process or consequence presumably is such that the proliferation may continue.  In science and linguistics, the derived forms (used both hyphenated and not) include animutation, antimutation, backmutation, e-mutation, ectomutation, endomutation, epimutation, extramutation, frameshift mutation, hard mutation, heteromutation, homomutation, hypermutation, hypomutation, i-mutation, intermutation, intramutation, intromutation, macromutation, macromutational, megamutation, mesomutation, micromutation, missense mutation, mixed mutation, multimutation, mutationless, mutation pressure, nasal mutation, neomutation, nonsense mutation, oncomutation, paramutation. Pentamutation, phosphomutation. point mutation, postmutation, premutation, radiomutation, retromutation, soft mutation, spirant mutation, stem mutation, stereomutation, ultramutation & vowel mutation.

Ginger, copper, auburn & chestnut are variations on the theme of red-headedness: Ranga Lindsay Lohan demonstrates the possibilities.

Red hair is the result of a mutation in the melanocortin 1 receptor (MC1R) gene responsible for producing the MC1R protein which plays a crucial role also in determining skin-tone. When the MC1R gene is functioning normally, it helps produce eumelanin, a type of melanin that gives hair a dark color.  However, a certain mutation in the MC1R gene leads to the production of pheomelanin which results in red hair.  Individuals with two copies of the mutated MC1R gene (one from each parent) typically have red hair, fair skin, and a higher sensitivity to ultraviolet (UV) light, a genetic variation found most often in those of northern & western European descent.

A mutation is a change in the structure of the genes or chromosomes of an organism and mutations occurring in the reproductive cells (such as an egg or sperm), can be passed from one generation to the next.  It appears most mutations occur in “junk DNA” and the orthodox view is these generally have no discernible effects on the survivability of an organism.  The term junk DNA was coined to describe those portions of an organism's DNA which do not encode proteins and were thought to have no functional purpose (although historically there may have been some).  The large volume of these “non-coding regions” surprised researchers when the numbers emerged because the early theories had predicted they would comprise a much smaller percentage of the genome.  The term junk DNA was intentionally dismissive and reflected the not unreasonable assumption the apparently redundant sequences were mere evolutionary “leftovers” without an extant biological function of any significance.

However, as advances in computing power have enabled the genome further to be explored, it’s been revealed that many of these non-coding regions do fulfil some purpose including: (1) A regulatory function: (the binary regulation of gene expression, influencing when, where, and how genes are turned on or off; (2) As superstructure: (Some regions contribute to the structural integrity of chromosomes (notably telomeres and centromeres); (3) In RNA (ribonucleic acid) molecules: Some non-coding DNA is transcribed into non-coding RNA molecules (such as microRNAs and long non-coding RNAs), which are involved in various cellular processes; (4) Genomic Stability: It’s now clear there are non-coding regions which contribute to the maintenance of genomic stability and the protection of genetic information.  Despite recent advances, the term junk DNA is still in use in mapping but is certainly misleading for those not immersed in the science; other than in slang, in academic use and technical papers, “non-coding DNA” seems now the preferred term and where specific functions have become known, these regions are described thus.

There’s also now some doubt about the early assumptions that of the remaining mutations, the majority have harmful effects and only a minority operate to increase an organism's ability to survive, something of some significance because a mutation which benefits a species may evolve by means of natural selection into a trait shared by some or all members of the species.  However, there have been suggestions the orthodox view was (at least by extent) influenced by the slanting of the research effort towards diseases, syndromes and other undesirable conditions and that an “identification bias” may thus have emerged.  So the state of the science now is that there are harmful & harmless mutations but there are also mutations which may appear to have no substantive effect yet may come to be understood as significant, an idea which was explored in an attempt to understand why some people found to be inflected with a high viral-load of SARS-Cov-2 (the virus causing Covid-19) remained asymptomatic.

In genetics, a mutation is a change in the DNA sequence of an organism and it seems they can occur in any part of the DNA and can vary in size and type.  Most associated with errors during DNA replication, mutations can also be a consequence of viral infection or exposure to certain chemicals or radiation, or as a result of viral infections.  The classification of mutations has in recent years been refined to exist in three categories:

(1) By the Effect on DNA Sequence:  These are listed as Point Mutations which are changes in a single nucleotide and include (1.1) Substitutions in which one base pair is replaced by another, (1.2) Insertions which describe the addition of one or more nucleotide pairs and (1.3) Deletions, the removal of one or more nucleotide pairs.

(2) By the Effect on Protein Sequence: These are listed as: (2.1) Silent Mutations which do not change the amino acid sequence of the protein, (2.2) Missense Mutations in which there is a change one amino acid in the protein, potentially affecting its function, (2.3) Nonsense Mutations which create a premature stop codon, leading to a truncated and usually non-functional protein and (2.4) Frameshift Mutations which result from insertions or deletions that change the reading frame of the gene, often leading to a completely different and non-functional protein.

(3) By the Effect on Phenotype: These are listed as (3.1) Beneficial Mutations which provide some advantage to the organism, (3.2) Neutral Mutations which have no apparent significant effect on the organism's fitness and (3.3) Deleterious Mutations which are harmful to the organism and can cause diseases or other problems.

(4) By the Mechanism of Mutation: These are listed as (4.1) Spontaneous Mutations which occur naturally without any external influence, due often to errors in DNA replication and (4.2) Induced Mutations which result from exposure to mutagens environmental factors such as chemicals or radiation that can cause changes in DNA),

Because of the association with disease, genetic disorders and disruptions to normal biological functions, in the popular imagination mutations are thought undesirable.  They are however a crucial part of the evolutionary process and life on this planet as it now exists would not be possible without the constant process of mutation which has provided the essential genetic diversity within populations and has driven the adaptation and evolution of species.  Although it will probably never be known if life on earth started and died out before beginning the evolutionary chain which endures to this day, as far as is known, everything now alive (an empirically, that means in the entire universe) ultimately has a single common ancestor.  Mutations have played a part in the diversity which followed and of all the species which once have inhabited earth, a tiny fraction remain, the rest extinct.

Nuclear-induced mutations

Especially since the first A-Bombs were used in 1945, the idea of “mutant humans” being created by the fallout from nuclear war or power-plants suffering a meltdown have been a staple for writers of science fiction (SF) and producers of horror movies, the special-effects and CGI (computer generated graphics) crews ever imaginative in their work.  The fictional works are disturbing because radiation-induced human mutations are not common but radiation can cause changes in DNA, leading to mutations and a number of factors determine the likelihood and extent of damage.  The two significant types of radiation are: (1) ionizing radiation which includes X-rays, gamma rays, and particles such as alpha and beta particles.  Ionizing radiation has enough energy to remove tightly bound electrons from atoms, creating ions and directly can damage DNA or create reactive oxygen species that cause indirect damage.  In high doses, ionizing radiation can increase the risk of cancer and genetic mutations and (2) non-ionizing radiation which includes ultraviolet (UV) light, visible light, microwaves, and radiofrequency radiation.  Because this does not possess sufficient energy to ionize atoms or molecules, which there is a risk of damage to DNA (seen most typically in some types of skin cancer), but the risk of deep genetic mutations is much lower than that of ionizing radiation.  The factors influencing the extent of damage include the dose, duration of exposure, the cell type(s) affected, a greater or lesser genetic predisposition and age.

Peter Dutton (b 1970; leader of the opposition and leader of the Australian Liberal Party since May 2022) announces the Liberal Party's new policy advocating the construction of multiple nuclear power-plants in Australia.

The prosthetic used in the digitally-altered image (right) was a discarded proposal for the depiction of Lord Voldemort in the first film version of JK Rowling's (b 1965) series of Harry Potter children's fantasy novels; it used a Janus-like two-faced head.  It's an urban myth Mr Dutton auditioned for the part when the first film was being cast but was rejected as being "too scary".  If ever there's another film, the producers might reconsider and should his career in politics end (God forbid), he could bring to Voldemort the sense of menacing evil the character has never quite achieved.  Interestingly, despite many opportunities, Mr Dutton has never denied being a Freemason.

On paper, while not without challenges, Australia does enjoy certain advantages in making nuclear part of the energy mix: (1)  With abundant potential further to develop wind and solar generation, the nuclear plants would need only to provide the baseload power required when renewable sources were either inadequate or unavailable; (2) the country would be self-sufficient in raw uranium ore (although it has no enrichment capacity) and (3) the place is vast and geologically stable so in a rational world it would be nominated as the planet's repository of spent nuclear fuel and other waste.  The debate as it unfolds is likely to focus on other matters and nobody images any such plant can in the West be functioning in less than twenty-odd years (the Chinese Communist Party (CCP) gets things done much more quickly) so there's plenty of time to squabble and plenty of people anxious to join in this latest theatre of the culture wars.  Even National Party grandee Barnaby Joyce (b 1967; thrice (between local difficulties) deputy prime minister of Australia 2016-2022) has with alacrity become a champion of all things nuclear (electricity, submarines and probably bombs although, publicly, he seems not to have discussed the latter).  The National Party has never approved of solar panels and wind turbines because they associate them with feminism, seed-eating vegans, homosexuals and other symbols of all which is wrong with modern society.  While in his coal-black heart Mr Joyce's world view probably remains as antediluvian as ever, he can sniff the political wind in a country now beset by wildfires, floods and heatwaves and talks less of the beauty of burning fossil fuels.  Still, in the wake of Mr Dutton's announcement, conspiracy theorists have been trying to make Mr Joyce feel better, suggesting the whole thing is just a piece of subterfuge designed to put a spanner in the works of the transition to renewable energy generation, the idea being to protect the financial positions of those who make much from fossil fuels, these folks being generous donors to party funds and employers of "helpful" retired politicians in lucrative and undemanding roles.

Bonk

Bonk (pronounced bongk)

(1) A bump on the head (usually not severe).

(2) To hit, strike, collide etc; any minor collision or blow.

(3) In slang, a brief intimacy between two people, usually with a suggestion of infidelity; often modified with the adjective quick and only ever used where the act is consensual (less common in North America).

(4) In sports medicine, a condition of sudden, severe fatigue in an endurance sports event, typically induced by glycogen depletion (also in the phrase “hit the wall”).

(5) In snowboarding, to hit something with the front of the board, especially in midair.

(6) In zoology, an animal call resembling "bonk" (such as the call of the pobblebonk (any of various Australian frogs of the genus Limnodynastes)).

1931: A creation of Modern English, the origin remains uncertain but most suspect it was likely imitative of sounds of impact (like bong, bump, bounce or bang) and thus onomatopoetic.  As a slang term for an affaire de coeur, use was first noted in 1975 and has always, depending on context, carried an implication of something illicit or quickly done; purely recreational though always consensual.  The use in sports medicine describing the condition of glycogen depletion references a metaphorical impact as in “hitting the wall”, the first known use in 1952 in endurance sports medicine.  Bonkee, as a descriptor for a "woman of loose virtue", appears to have been a 2014 creation which never caught on which is a shame because there are all sorts of cases where the companion terms "bonker" & "bonkee" might have been handy .  The form "bonkers", referring to the deranged, dated from circa 1957 and was apparently unrelated to the earlier naval slang for “drunk” but alluded rather to what could be the the consequence of a “bonk on the head”.  The third-person singular simple present is bonks, the present participle, bonking and the simple past and past participle, bonked.  Bonk & bonking are nouns & verbs, bonker is a noun, bonky is an adjective, bonked is a verb and bonkers is a noun & adjective; the noun plural is bonks.

Bonkers: "Last Call" 2023 Dodge Challenger SRT Demon 170 in "plum crazy" (one of the retro colors which reprised those used by Chrysler in the "psychedelic era" of the late 1960s).  3300 were produced, many of which are now being advertised for sale at well above the RRP (recommended retail price).

The Demon 170 was released as part of Dodge’s “Last Call” programme which marked the end of the corporation's run of high-performance V8s, a tradition dating from the early 1950s.  Offered in a bewildering array of configurations in a process which was something like Nellie Melba's (1861-1931) "farewell" tours, the SRT Demon 170 was the most bonkers of a generally bonkers lot.  Rated at 1,025 hp (764 kW), the factory claimed it could accelerate from 0-60 mph (100 km/h) in 1.66 seconds with an elapsed time in the standing ¼ mile (400 metres for those who insist) of 8.91 seconds (terminal speed 151 mph (243 km/h)), setting the mark as the worlds quickest ever standard production car, a reasonable achievement for something weighing 4275 lbs (1939 kg).  By world standards it was also very cheap and on the basis of cost-breakdown vs performance, there was nothing like it on the planet.  In British (and other English-speaking regions although rare in the US) use, "bonkers" can and often is used in an entirely non-pejorative way to suggest something or someone verging on the irrational but in some way astonishing, admirable or inspiring.  Road cars with 600+ horsepower V8 & V12 engines are of course bonkers but we'll miss them when they're gone and it would seem the end is nigh.  Greta Thunberg (b 2003) has expressed no regret at the extinction of this species.  

Bonking Boris

Hand-turned fish bonkers on sale in Jaffray, a village in the south-western Canadian province of British Columbia (left) and the front page of The Sun (7 September 2018; right), a tabloid which rarely lets an alliterative opportunity pass by.  

The noun bonker is (1) a short, blunt hardwood club used by fishers efficiently to dispatch (ie bonking them dead) just-caught fish and (2) according to the Murdoch tabloid The Sun, the adulterous Boris Johnson (b 1964; UK prime-minister 2019-2022).  A bonk by Boris or the club and a not wholly dissimilar outcome ensues; a one-time employer called bonking Boris "ineffably duplicitous" and the estranged (now former) Mrs Johnson presumably agreed.  At the time, the former prime minister had "a bit of previous" in extra-marital bonking and when this one was announced, it was with an alliterative flourish not seen since the headline “BORIS BACKS BREXIT”.  His resignation from Theresa May's (Lady May, b 1956; UK prime-minister 2016-2019) government was unrelated to bonking (as far as is known) and came, in July 2018, three days after a cabinet meeting at Chequers (the prime-minister's country house), where agreement was reached on Mrs May’s Brexit strategy, a document compromised by the need to make a nonsensical impossibility look like good policy.  That can be done but it requires rare skill to be in Downing Street and it's been some time since that could be said. 

Freed by his resignation from the burdens of the Foreign Office, bonking Boris was clearly unconcerned at rumors his opponents in the party were assembling a dossier of some four-thousand words detailing his cheating ways, fondness for cocaine and failings of character and turned his attention to a campaign for the Tory leadership.  As wonderfully unpredictable as the politics of the time were fluid, nobody was quite sure whether he’d go into the inevitable election or second referendum as "leave" or "remain"; it would depend on this and that.  In the end, he remained a leaver and things worked out well, his election victory meaning that for one, brief, shining moment, the three world leaders with the best hair all had nuclear weapons at the same time.

Donald Trump (b 1946; US president 2017-2021; left), Boris Johnson (centre) and Kim Jong-un (Kim III, b 1982; Supreme Leader of DPRK (North Korea) since 2011; right).

Some hairstyles are more amenable than others to a quick post-bonk rectification.  Kim Jong-un's cut is probably quite good and would bounce back from a bonk with little more than a run-through with the fingers.  Donald Trump however would likely need both tools and product for a post-bonk fix.  Mr Trump usually appears well-fixed unless disturbed by breezes any higher than 2 on the Beaufort scale and even a perfunctory bonk is probably equal to at least 4 on the scale so it would have been interesting to see if Stormy Daniels (Stephanie Gregory, b 1979) lived up to her (stage) name although Mr Trump has denied that bonk ever happened.  Mr Johnson's hair so often looks post-bonk that either his conquests are more frequent even than has been rumored or he asks for a JBF with every cut.  One UK publication suggested exactly that, hinting his instruction was "not one hair in place".  That has the advantage for Mr Johnson in that it's a style essentially the same pre-bonk, mid-bonk and post-bonk and thus pricelessly ambiguous in that merely by looking at him, one couldn't tell if he was going to or coming from a bonk although, one assumes, whichever it was, a bonk would never be far from his mind.  Whatever the criticisms of Mr Johnson's premiership (and there were a few), it's to his eternal credit that in his resignation honours list Ms Kelly Jo Dodge (for 27 years the parliamentary hairdresser) was created a Member of the Most Excellent Order of the British Empire (MBE) for "parliamentary service".  In those decades, she can have faced few challenges more onerous than Mr Johnson’s hair yet never once failed to make it an extraordinary example in the (actually technically difficult) “not one hair in place” style.  Few honours have been so well deserved.

A bandaged Lindsay Lohan waking dazed and confused after a bonk on the head in Falling for Christmas (2022; left) and on the move in Irish Wish (2024).   

In May 2021, Netflix & Lindsay Lohan executed what became a three movie deal, the first (Falling for Christmas) released in the northern winter of 2022, just in time for the season.  She played the protagonist, a pampered heiress who loses her memory after suffering a bonk on the head, waking up to a new life.  The second Netflix release opens in February 2024 and in Irish Wish, the plotline involves her spontaneously wishing for something, subsequently waking up to find the wish granted.  So it’s a variation on the theme of the first (though without the bonk on the head), the twist being in the theme of “be careful what you wish for”.

Bonking Barnaby and the bonk ban

Malcolm Turnbull (b 1954; prime-minister of Australia 2015-2018), a student of etymology, was as fond as those at The Sun of alliteration and when writing his memoir (A Bigger Picture (2020)) he included a short chapter entitled "Barnaby and the bonk ban".  As well as the events which lent the text it's title, the chapter was memorable for his inclusion of perhaps the most vivid thumbnail sketch of Barnaby Joyce (b 1967; thrice (between local difficulties) deputy prime minister of Australia 2016-2022) yet penned:

"Barnaby is a complex, intense, furious personality.  Red-faced, in full flight he gives the impression he's about to explode.  He's highly intelligent, often good-humoured but also has a dark and almost menacing side - not unlike Abbott (Tony Abbott (b 1957; prime-minister of Australia 2013-2015)) - that seems to indicate he wrestles with inner troubles and torments."

Mr Turnbull and Mr Joyce in parliament, House of Representatives, Canberra, ACT.

The substantive matter was the revelation in mid-2017 the press had become aware Mr Joyce (a married man with four daughters) was (1) conducting an affair with a member of his staff and (2) that the young lady was with child.  Mr Turnbull recorded that when asked, Mr Joyce denied both "rumors", which does sound like a lie but in the narrow sense may have verged on "the not wholly implausible" on the basis that, as he pointed out in a later television interview, the question of paternity was at the time “...a bit of a grey area”.  Mr Joyce and his mistress later married and now have two children so all's well that end's well (at least for them) and Mr Turnbull didn't so much shut the gate after the horse had bolted as install inter-connecting doors in the stables.  His amendments to the Australian Ministerial Code of Conduct (an accommodating document very much in the spirit of Lord Castlereagh's (1769–1822; UK foreign secretary 1812-1822) critique of the Holy Alliance) banned ministers from bonking their staff which sounds uncontroversial but was silent on them bonking the staff of the minister in the office down the corridor.  So the net effect was probably positive in that staff having affairs with their ministerial boss would gain experience through cross-exposure to other portfolio areas although there's the obvious moral hazard in that they might be tempted to conduct trysts just to engineer a transfer in the hope of career advancement.  There are worse reasons for having an affair and a bonk for a new job seems a small price to pay.  It's been done before.

Bonk in progress, California State Polytechnic University, Humboldt, May 2024.

Bonk in the sense of “a blow to the head” was in May 2024 adapted for use in memes and other publicity tools associated with the protests staged on US university campuses demanding the institutions’ administrators divest from economic and other engagements with Israel and in support of the cause of the Palestinian people for (variously) statehood or freedom from repression.  The scenes were reminiscent of Vietnam War era protests but the emergence of the water-cooler jug as an icon of political dissent was an unexpected moment of levity.  The origin of that was a viral (“bonk, bonk, bonk”) video clip showing an unidentified protester at the California State Polytechnic University, Humboldt bonking a uniformed law-enforcement officer on the helmet with an empty jug (believed to be a capacity of 5 US gallons (19 litres)) of the type which sits atop a water cooler.

Although recalling the similarly alliterative “burn baby, burn” slogan chanted during the Watts race riots in Los Angeles in August 1965, the “bonk, bonk, bonk” was more a symbol of, if not exactly passive resistance, then certainly something short of actual violence although in a legal sense it may have been an instance of both assault and battery as well as other offences.  Around the country, stickers, posters and the inevitable T-shirts appeared within hours with slogans such as “Water Jug, Come and Take It” and “This machine bonks fascists”, a reference to the “THIS MACHINE KILLS FASCISTS” message the left-wing US folk singer Woody Guthrie (1912–1967) wrote on his guitars.  Whether the water jug (bonking and not) will endure as a symbol of protest will depend, like many aspects of language, on whether it gains a sustained critical mass of use.

The "bonk, bonk, bonk" viral video.  In the conventional sense the production values weren't high but that very quality of authenticity accounted for its success.