Virus

Virus (pronounced vahy-ruhs)

(1) An sub- or ultra-microscopic (20 to 300 nm diameter), metabolically inert, non-cellular infectious agent that replicates only within the cells of living hosts, mainly bacteria, plants, and animals: composed of an RNA or DNA core, a protein coat, and, in more complex types, a surrounding envelope.  Because viruses are unable to replicate without a host cell, they are not considered living organisms in conventional taxonomic systems (though often referred to as live (in the sense of active) when replicating and causing disease.

(2) A quantity of such infectious agents.

(3) In informal use, metonymically, A disease caused by such an infectious agent; a viral illness.

(4) Venom, as produced by a poisonous animal etc (extinct in this context). 

(5) Figuratively, any malicious or dangerous entity that spreads from one place or person to another; a corrupting influence on morals or the intellect. 

(6) In computing, a segment of often self-replicating code furtively planted in a computer program, either to damage a system or for financial gain by a variety of fraudulent techniques.

(7) In computing (loosely used), any form of malware.

Late 1300s: From the Middle English virus (poisonous substance (this meaning now extinct in this context)), from the Latin vīrus (slime; venom; poisonous liquid; sap of plants; slimy liquid; a potent juice), from rhotacism from the Proto-Italic weisos & wisós (fluidity, slime, poison) probably from the primitive Indo-European root ueis & wisós (fluidity, slime, poison (though it may originally have meant “to melt away, to flow”), used of foul or malodorous fluids, but in some languages limited to the specific sense of "poisonous fluid") which was the source also of the Sanskrit visam (venom, poison) & visah (poisonous), the Avestan vish- (poison), the Latin viscum (sticky substance, birdlime), the Greek ios (poison) & ixos (mistletoe, birdlime), the Old Church Slavonic višnja (cherry), the Old Irish fi (poison) and the Welsh gwy (poison).  It was related also to the Old English wāse (marsh).  Virus is a noun & a (rare) verb and viral is an adjective; the noun plural is viruses.

The original meaning, "poisonous substance”, emerged in the late fourteenth century and was an inheritance from the Latin virus (poison, sap of plants, slimy liquid, a potent juice) from the Proto-Italic weis-o-(s-) (poison), probably from the primitive Indo-European root ueis-, thought originally to mean "to melt away, to flow" and used of foul or malodorous fluids, but with specialization in some languages to mean "poisonous fluid".  It’s the source of the Sanskrit visam (venom, poison) & visah (poisonous), the Avestan vish- (poison), the Latin viscum (sticky substance; birdlime) the Greek ios (poison) & ixos (mistletoe, birdlime), the Old Church Slavonic višnja (cherry). The Old Irish fi (poison) and the Welsh gwy (poison).  The meaning "agent that causes infectious disease" emerged in the 1790s, the medical literature of the time describing their manifestation in  especially disgusting terms (the word pus most frequent) and one dictionary entry of 1770 contains the memorable: "a kind of watery stinking matter, which issues out of ulcers, being endued with eating and malignant qualities".  As early as 1728 (borrowing from the earlier sense of "poison"), it had been used in reference to venereal disease, the first recognizably modern scientific use dating from the 1880s.  The first known citation in the context of computing was by Gregory Benford (b 1941) who published The Scarred Man (1970) although it’s often credited to David Gerrold (b 1944), who used the word in this context in When HARLIE Was One (1972).

Before the internet: ARPANET network schematic 1973.

In computing, theoretical work on the self-replicating code (which is the core of a digital virus) was published as early as 1971 and what’s regarded as the first object to behave like a virus (though technically, it would now be called a worm) was released as a harmless amusement on ARPANET (Advanced Research Projects Agency Network) (ARPANET), the internet’s precursor network.  It was called “creeper, catch me if you can!" and, perhaps predictably, other nerds rose to the challenge and release the “reaper” their own worm which killed whatever creepers it found.  Creeper & reaper conducted their cat & mouse game on Digital Equipment Corporation's (DEC) PDP-10, predecessor to the famous PDP-11 mini-computer and at this point, viruses were genuinely harmless (if time wasting) activities conducted between consenting nerds in the privacy of their parochial networks.  However, it was the development of the personal computer (PC) from 1975 and especially the subsequent adoption by business of the IBM-PC-1 (1981) and its clones which created the population in which viruses could spread and while relatively harmless creations like Stoned (1987) tended to amuse because they did little more that display on the screen of an infected device the message "Your PC is now Stoned", there were many others which were quite destructive.  The first which came to wide public attention was probably Melissa (1999) which caused much economic loss and the discussion of which (by mostly male writers in the specialist press) excited some criticism from feminists who objected to headlines like "Melissa was really loose, and boy did she get around".    

The late John McAfee (1945–2021) who led an interesting life.

In medicine, the first antivirus was available in 1903, an equivalent (shrink-wrap) product for computers apparently first offered for sale in 1987 although there seems no agreement of which of three authors (Paul Mace, Andreas Lüning & the late John McAfee) reached the market first.  The adjective viral (of the nature of, or caused by, a virus) dates from 1944 as applied in medicine whereas the now equally familiar, post world-wide-web sense of stuff "become suddenly popular through internet sharing" is attested by 1999 although most seem convinced it must have been in use prior to this.

The rhinovirus (one of a group of viruses that includes those which cause many common colds) was first described in 1961, the construct being rhino- (from the Ancient Greek rhino (a combining form of rhis (nose) of uncertain origin) + virus.  The noun virology appeared in 1935 to describe the then novel branch of science and parvovirus (a very small virus), the construct being parvi- (small, little) + the connecting element -o- + virus was coined in 1965 to describe the decreasingly small objects becoming visible as optical technology improved.  The rotavirus (a wheel-shaped virus causing inflammation of the lining of the intestines), the construct being rota (wheel) + virus dates from 1974.

Diagram of a retrovirus.

The adjective virulent dates from circa 1400 in reference to wounds, ulcers etc (full of corrupt or poisonous matter), from the Latin virulentus (poisonous), from virus; the figurative sense of "violent, spiteful" attested from circa 1600; virulently the related form.  The mysterious reovirus was a noun coined in 1959 by Polish-American medical researcher Dr Albert Sabin (1906-1993), the “reo-“ and acronym for “respiratory enteric orphan”, to describe viruses considered orphans in the sense of not being connected to any of the diseases with which they were associated.  More technical still was the (1977) retrovirus, an evolution of the (1974) retravirus (from re(verse) tra(nscriptase) + connective -o- + virus), explained by it containing reverse transcriptase, an enzyme which uses RNA instead of DNA to encode genetic information, thus reversing the usual pattern.  While these things are usually the work of committees, there seems to be nothing in the public record to suggest why “retro-“ was preferred to “retra-“, the assumption being “retro-“ more explicitly indicated "backwards."

In 2014, while in the South Pacific, Lindsay Lohan contracted Chikungunya, an infection caused by the Chikungunya virus (CHIKV), spread by two types of mosquito.  On Twitter and Instagram, she recommended the use of bug spray.  The condition was first isolated in Tanzania in 1952, the word Chikungunya from the Kimakonde language which translates literally as "to become contorted" although the World Health Organization (WHO) lists the common symptoms as a persistent headache, swollen joints, muscle pain and a rash which typically appears first on the extremities.

Chikungunya virus (CHIKV) assembly and egress.

Not alive in the technical sense defined in biology, a virus is a biological agent which reproduces inside the cells of living hosts.  When infected by a virus, a host cell is forced quickly to produce thousands of identical copies of the original; unlike actual living things, viruses do not have cells that divide, new viruses being assembled in the infected host cell.  Unlike simpler infectious agents, viruses contain genes so they mutate and evolve and thousands are known to exist.  Viruses are tiny, much smaller than bacteria and it can require more than a million of them, side by side, to reach one inch (25 mm) and although a theory of viruses was constructed after French and Russian experiments in the 1880s, it wasn’t until the electron microscope became available in 1931 that the first images were captured.  Where there is life, there are viruses and it’s thought likely they have existed either since, or very shortly after, the first living cells evolved; it’s not impossible the first cellular forms would now, technically, be classified as viruses.  Viruses can be benign and bacteriophages are viruses that infect bacteria, used in eastern Europe since the nineteenth century to treat infection but almost ignored since the development of antibiotics.  With the growth in antibiotic resistance, there’s now renewed interest.  Viruses also perform a useful role in ecology, killing around a fifth of oceanic biomass, the increased respiration in the seas ultimately reducing the atmospheric carbon dioxide by some three gigatons per year.

During the initial 2019 outbreak in Wuhan of what is now called COVID-19, both virus and disease were mostly referred to as "coronavirus", "Wuhan coronavirus" or "Wuhan pneumonia".  There had been a long tradition of naming diseases after the geographical location where they were first reported (Hong Kong flu, Spanish flu etc) but this could be misleading.  The Spanish flu, associated with the pandemic of 1918-1920, was actually first detected elsewhere, either on the World War I battlefields of France or (more probably) a military camp in the United States but, because Spain was a neutral in the conflict, there was no military censorship to limit reporting so warnings about this especially virulent influenza were printed in the Spanish press.  From here, it was eventually picked up and publicized as “Spanish flu” although, doctors there, in an early example of contract tracing, were aware of vectors of transmission and insisted it was the “French flu” because this was where their back-tracing led.  This had no effect beyond Spain and it’s ever since been known as “Spanish flu” although the practice of using geographical references has now been abandoned, a linguistic sanitization which has extended to anything likely to cause offence, the recently topical Monkeypox now called Mpox which seems hardly imaginative.     

Representation of a coronavirus.

In January 2020, the World Health Organization’s (WHO) International Committee on Taxonomy of Viruses (ICTV) recommended the name 2019-nCoV & 2019-nCoV acute respiratory disease as interim names for virus and disease respectively (although “human coronavirus 2019”, “HCoV-19” & “hCoV-19” also exist in the record).  The committee’s recommendation conformed to the conventions adopted after it was decided in 2015, to avoid social stigma, to cease the use of geographical locations or identities associated with specific people(s) in disease-related names.  Although well understood by scientists, the WHO must have thought them a bit much for general use and in February 2020, issued SARS-CoV-2 & COVID-19 as the official nomenclature: CO=corona, VI=virus, D=disease & 19=2019 although for a while, confusingly, documents issued by the WHO sometimes referenced “COVID-19 virus” rather than the correct SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; the name adopted because of the close genetic relationship to the first SARS outbreak in 2003 (now retrospectively listed as SARS-Cov-1).