Atrophy & Hypertrophy

Atrophy (pronounced a-truh-fee)

(1) In pathology, a wasting away of the body or of an organ or part, or a failure to grow to normal size as the result of disease, defective nutrition, nerve damage or hormonal changes.

(2) Degeneration, decline, or decrease, as from disuse.

1590–1600: From the earlier Middle French atrophie and Late Latin atrophia from the Ancient Greek ἀτροφία (atrophía) (a wasting away), (derived from trephein (to feed)) from ἄτροφος (átrophos) (ill-fed, un-nourished), the construct being ἀ- (a-) (not) + τροφή (trophḗ) (nourishment) from τρέφω (tréphō) (I fatten).  Atrophic is the most familiar adjectival form.  The a- prefix, a proclitic form of preposition, is from the Ancient Greek ἀ- (not, without) and is used to form taxonomic names indicating a lack of some feature that might be expected.  In Middle English a- (up, out, away) was from the Old English ā- (originally ar- & or-) from the Proto-Germanic uz- (out-), from the primitive Indo-European uds- (up, out); it was cognate with the Old Saxon ā- and the German er-.  The suffix –ia is from Classical Latin from the Ancient Greek -ία (-ía) & -εια (-eia) and was used to form abstract nouns of feminine gender.  It creates names of countries, diseases, flowers, and (rarely) collections of things such as militaria & deletia).  The spelling atrophia is obsolete.  Atrophy is a noun and atrophic is an adjective; the noun plural is atrophies.  The noun atrophication is non-standard and seems to be restricted to the pro-ana community, usually as "self-atrophication".

Self-atrophication: Lindsay Lohan during "thin phase".

In pathology there are specific classes of atrophy including encephalatrophy (atrophy of the brain), fibroatrophy (atrophy of fibres), dermatrophy (atrophy (a thinning) of the skin), lipoatrophy (the loss of subcutaneous fatty tissue), scleroatrophy (Any of various atrophic conditions characterized by a hardening of tissue, including atrophic fibrosis of the skin, hypoplasia of the nails, and palmoplantar keratoderma), hemiatrophy (atrophy that affects only one half of the body) and the mysterious pseudoatrophy (where tissue (typically muscle), appears to have reduced in size or wasted away but the perceived reduction is really caused by factors such as swelling, inflammation, or the presence of fluid in surrounding tissues that make the muscle look smaller than it actually is).  In genetics, atrogene describes any gene which has some influence on atrophy of muscle tissue and in biochemistry atrophins are any of a class of proteins found in nervous tissue.

Hypertrophy (pronounced hahy-pur-truh-fee)

(1) In physiology, the abnormal (but usually non-tumorous) enlargement of an organ or a tissue as a result of an increase in the size rather than the number of constituent cells.

(2) In bodybuilding, an increase in muscle size through increased size of individual muscle cells (responding to exercise such as weightlifting); it is distinct from muscle hyperplasia (the formation of new muscle cells).

(2) Excessive growth or accumulation of any kind.

1825–1835: A compound word hyper- + -trophy.  Hyper is from the French hypertrophie, from the Ancient Greek ὑπέρ (hupér) (over, excessive), from the primitive Indo-European upér (over, above) (from which English gained over), from upo (under, below) (source of the English up). It was cognate with the Latin super- and is a common prefix appearing in loanwords from Greek, where it meant “over,” usually implying excess or exaggeration (eg hyperbole); on this model used, especially as opposed to hypo-, in the formation of compound words.  Hypertrophy is a noun & verb, hypertrophic, hypertrophical, hypertrophous & hypertrophical are adjectives and hypertrophically is an adverb; the noun plural is hypertropheries.  For those for whom the successively multi-syllabic is a fetish or compile scripts for speech therapy practice, there's hypertrophic pulmonary osteoarthropathy (in pathology, a paraneoplastic condition characterised by clubbing and periostitis of the long bones of the arms and legs).

Two “Chernobyl mutant catfish” (left) and one with a human for scale (right).  They're now found in the cooling ponds of the Chernobyl nuclear reactor which in 1986 suffered a meltdown and subsequent explosion.

Their huge size is not a radiation-induced mutation but a result of the absence of a predator since humans were removed from their environment.  As far as is known, radiation-induced mutations very rarely lead to a generalized hypertrophy and it's much more common for an affected specimen to grow “less efficiently” and for a variety of reasons they can be less capable of catching food and thus not live as long as is typical for the species.  The “Chernobyl mutant catfish” which gained their infamy in the early days of the internet were no more the result of nuclear contamination than the “Fukushima mutant wolfish” of the social media age.  Genetically, there’s nothing novel about the size of the bulky inhabitants of the Chernobyl ponds.  While it’s not typical, the wels catfish (Silurus glanis) can weigh over 350 kg (770 lb), examples recorded both in scientific research and by fishers although up to 150 kg (330 lb) is more common for a large example.  So, to describe the big fish as “hypertrophic” is to use the word in a loose way because the growth registered is “extreme” rather than excessive, something made possible by them living without predators, in a suitable habitat with ample food.  With humans no longer killing them, the catfish have become both apex-level predators and scavengers, enjoying fish, amphibians, worms, birds and even small mammals; they appear to eat just about anything (dead or alive) which fits into their large mouths.  They can live for many decades and scientists are monitoring their progress in what is a close to unique experiment.  Thus far, despite some being tested as being some 16 times more radioactive than normal, the indications are they’re continuing happily to feed, re-produce and grow but because the hypertrophied state is function of genetics interacting with an ideal environment, it’s thought unlikely they’ll ever exceed the recorded maximum size.

Peter Dutton (b 1970; leader of the opposition and leader of the Australian Liberal Party since May 2022) announces the Liberal Party's new policy advocating the construction of multiple nuclear power-plants in Australia.  The prosthetic used in the digitally-altered image (right) was a discarded proposal for the depiction of Lord Voldemort in the first film version of JK Rowling's (b 1965) series of Harry Potter children's fantasy novels; it used a Janus-like two-faced head.  It's an urban myth Peter Dutton auditioned for the part when the first film was being cast but was rejected as being "too scary".  If ever there's another film, the producers might reconsider and should his career in politics end (God forbid), he could bring to Voldemort the sense of menacing evil the character has never quite achieved.  Interestingly, despite many opportunities, Mr Dutton has never denied being a Freemason.