Virus

Virus (pronounced vahy-ruhs)

(1) An sub- or ultra-microscopic (20 to 300 nm diameter), metabolically inert, non-cellular infectious agent that replicates only within the cells of living hosts, mainly bacteria, plants, and animals: composed of an RNA or DNA core, a protein coat, and, in more complex types, a surrounding envelope.  Because viruses are unable to replicate without a host cell, they are not considered living organisms in conventional taxonomic systems (though often referred to as live (in the sense of active) when replicating and causing disease.

(2) A quantity of such infectious agents.

(3) In informal use, metonymically, A disease caused by such an infectious agent; a viral illness.

(4) Venom, as produced by a poisonous animal etc (extinct in this context). 

(5) Figuratively, any malicious or dangerous entity that spreads from one place or person to another; a corrupting influence on morals or the intellect. 

(6) In computing, a segment of often self-replicating code furtively planted in a computer program, either to damage a system or for financial gain by a variety of fraudulent techniques.

(7) In computing (loosely used), any form of malware.

Late 1300s: From the Middle English virus (poisonous substance (this meaning now extinct in this context)), from the Latin vīrus (slime; venom; poisonous liquid; sap of plants; slimy liquid; a potent juice), from rhotacism from the Proto-Italic weisos & wisós (fluidity, slime, poison) probably from the primitive Indo-European root ueis & wisós (fluidity, slime, poison (though it may originally have meant “to melt away, to flow”), used of foul or malodorous fluids, but in some languages limited to the specific sense of "poisonous fluid") which was the source also of the Sanskrit visam (venom, poison) & visah (poisonous), the Avestan vish- (poison), the Latin viscum (sticky substance, birdlime), the Greek ios (poison) & ixos (mistletoe, birdlime), the Old Church Slavonic višnja (cherry), the Old Irish fi (poison) and the Welsh gwy (poison).  It was related also to the Old English wāse (marsh).  Virus is a noun & a (rare) verb and viral is an adjective; the noun plural is viruses.

The original meaning, "poisonous substance”, emerged in the late fourteenth century and was an inheritance from the Latin virus (poison, sap of plants, slimy liquid, a potent juice) from the Proto-Italic weis-o-(s-) (poison), probably from the primitive Indo-European root ueis-, thought originally to mean "to melt away, to flow" and used of foul or malodorous fluids, but with specialization in some languages to mean "poisonous fluid".  It’s the source of the Sanskrit visam (venom, poison) & visah (poisonous), the Avestan vish- (poison), the Latin viscum (sticky substance; birdlime) the Greek ios (poison) & ixos (mistletoe, birdlime), the Old Church Slavonic višnja (cherry). The Old Irish fi (poison) and the Welsh gwy (poison).  The meaning "agent that causes infectious disease" emerged in the 1790s, the medical literature of the time describing their manifestation in  especially disgusting terms (the word pus most frequent) and one dictionary entry of 1770 contains the memorable: "a kind of watery stinking matter, which issues out of ulcers, being endued with eating and malignant qualities".  As early as 1728 (borrowing from the earlier sense of "poison"), it had been used in reference to venereal disease, the first recognizably modern scientific use dating from the 1880s.  The first known citation in the context of computing was by Gregory Benford (b 1941) who published The Scarred Man (1970) although it’s often credited to David Gerrold (b 1944), who used the word in this context in When HARLIE Was One (1972).

Before the internet: ARPANET network schematic 1973.

In computing, theoretical work on the self-replicating code (which is the core of a digital virus) was published as early as 1971 and what’s regarded as the first object to behave like a virus (though technically, it would now be called a worm) was released as a harmless amusement on ARPANET (Advanced Research Projects Agency Network) (ARPANET), the internet’s precursor network.  It was called “creeper, catch me if you can!" and, perhaps predictably, other nerds rose to the challenge and release the “reaper” their own worm which killed whatever creepers it found.  Creeper & reaper conducted their cat & mouse game on Digital Equipment Corporation's (DEC) PDP-10, predecessor to the famous PDP-11 mini-computer and at this point, viruses were genuinely harmless (if time wasting) activities conducted between consenting nerds in the privacy of their parochial networks.  However, it was the development of the personal computer (PC) from 1975 and especially the subsequent adoption by business of the IBM-PC-1 (1981) and its clones which created the population in which viruses could spread and while relatively harmless creations like Stoned (1987) tended to amuse because they did little more that display on the screen of an infected device the message "Your PC is now Stoned", there were many others which were quite destructive.  The first which came to wide public attention was probably Melissa (1999) which caused much economic loss and the discussion of which (by mostly male writers in the specialist press) excited some criticism from feminists who objected to headlines like "Melissa was really loose, and boy did she get around".    

The late John McAfee (1945–2021) who led an interesting life.

In medicine, the first antivirus was available in 1903, an equivalent (shrink-wrap) product for computers apparently first offered for sale in 1987 although there seems no agreement of which of three authors (Paul Mace, Andreas Lüning & the late John McAfee) reached the market first.  The adjective viral (of the nature of, or caused by, a virus) dates from 1944 as applied in medicine whereas the now equally familiar, post world-wide-web sense of stuff "become suddenly popular through internet sharing" is attested by 1999 although most seem convinced it must have been in use prior to this.

The rhinovirus (one of a group of viruses that includes those which cause many common colds) was first described in 1961, the construct being rhino- (from the Ancient Greek rhino (a combining form of rhis (nose) of uncertain origin) + virus.  The noun virology appeared in 1935 to describe the then novel branch of science and parvovirus (a very small virus), the construct being parvi- (small, little) + the connecting element -o- + virus was coined in 1965 to describe the decreasingly small objects becoming visible as optical technology improved.  The rotavirus (a wheel-shaped virus causing inflammation of the lining of the intestines), the construct being rota (wheel) + virus dates from 1974.

Diagram of a retrovirus.

The adjective virulent dates from circa 1400 in reference to wounds, ulcers etc (full of corrupt or poisonous matter), from the Latin virulentus (poisonous), from virus; the figurative sense of "violent, spiteful" attested from circa 1600; virulently the related form.  The mysterious reovirus was a noun coined in 1959 by Polish-American medical researcher Dr Albert Sabin (1906-1993), the “reo-“ and acronym for “respiratory enteric orphan”, to describe viruses considered orphans in the sense of not being connected to any of the diseases with which they were associated.  More technical still was the (1977) retrovirus, an evolution of the (1974) retravirus (from re(verse) tra(nscriptase) + connective -o- + virus), explained by it containing reverse transcriptase, an enzyme which uses RNA instead of DNA to encode genetic information, thus reversing the usual pattern.  While these things are usually the work of committees, there seems to be nothing in the public record to suggest why “retro-“ was preferred to “retra-“, the assumption being “retro-“ more explicitly indicated "backwards."

In 2014, while in the South Pacific, Lindsay Lohan contracted Chikungunya, an infection caused by the Chikungunya virus (CHIKV), spread by two types of mosquito.  On Twitter and Instagram, she recommended the use of bug spray.  The condition was first isolated in Tanzania in 1952, the word Chikungunya from the Kimakonde language which translates literally as "to become contorted" although the World Health Organization (WHO) lists the common symptoms as a persistent headache, swollen joints, muscle pain and a rash which typically appears first on the extremities.

Chikungunya virus (CHIKV) assembly and egress.

Not alive in the technical sense defined in biology, a virus is a biological agent which reproduces inside the cells of living hosts.  When infected by a virus, a host cell is forced quickly to produce thousands of identical copies of the original; unlike actual living things, viruses do not have cells that divide, new viruses being assembled in the infected host cell.  Unlike simpler infectious agents, viruses contain genes so they mutate and evolve and thousands are known to exist.  Viruses are tiny, much smaller than bacteria and it can require more than a million of them, side by side, to reach one inch (25 mm) and although a theory of viruses was constructed after French and Russian experiments in the 1880s, it wasn’t until the electron microscope became available in 1931 that the first images were captured.  Where there is life, there are viruses and it’s thought likely they have existed either since, or very shortly after, the first living cells evolved; it’s not impossible the first cellular forms would now, technically, be classified as viruses.  Viruses can be benign and bacteriophages are viruses that infect bacteria, used in eastern Europe since the nineteenth century to treat infection but almost ignored since the development of antibiotics.  With the growth in antibiotic resistance, there’s now renewed interest.  Viruses also perform a useful role in ecology, killing around a fifth of oceanic biomass, the increased respiration in the seas ultimately reducing the atmospheric carbon dioxide by some three gigatons per year.

During the initial 2019 outbreak in Wuhan of what is now called COVID-19, both virus and disease were mostly referred to as "coronavirus", "Wuhan coronavirus" or "Wuhan pneumonia".  There had been a long tradition of naming diseases after the geographical location where they were first reported (Hong Kong flu, Spanish flu etc) but this could be misleading.  The Spanish flu, associated with the pandemic of 1918-1920, was actually first detected elsewhere, either on the World War I battlefields of France or (more probably) a military camp in the United States but, because Spain was a neutral in the conflict, there was no military censorship to limit reporting so warnings about this especially virulent influenza were printed in the Spanish press.  From here, it was eventually picked up and publicized as “Spanish flu” although, doctors there, in an early example of contract tracing, were aware of vectors of transmission and insisted it was the “French flu” because this was where their back-tracing led.  This had no effect beyond Spain and it’s ever since been known as “Spanish flu” although the practice of using geographical references has now been abandoned, a linguistic sanitization which has extended to anything likely to cause offence, the recently topical Monkeypox now called Mpox which seems hardly imaginative.     

Representation of a coronavirus.

In January 2020, the World Health Organization’s (WHO) International Committee on Taxonomy of Viruses (ICTV) recommended the name 2019-nCoV & 2019-nCoV acute respiratory disease as interim names for virus and disease respectively (although “human coronavirus 2019”, “HCoV-19” & “hCoV-19” also exist in the record).  The committee’s recommendation conformed to the conventions adopted after it was decided in 2015, to avoid social stigma, to cease the use of geographical locations or identities associated with specific people(s) in disease-related names.  Although well understood by scientists, the WHO must have thought them a bit much for general use and in February 2020, issued SARS-CoV-2 & COVID-19 as the official nomenclature: CO=corona, VI=virus, D=disease & 19=2019 although for a while, confusingly, documents issued by the WHO sometimes referenced “COVID-19 virus” rather than the correct SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; the name adopted because of the close genetic relationship to the first SARS outbreak in 2003 (now retrospectively listed as SARS-Cov-1).

Syndrome

Syndrome (pronounced sin-drohm or sin-druhm)

(1) In pathology and psychiatry, a group of symptoms which together are characteristic of a specific disorder, disease or the like.

(2) A group of related or coincident things, events, actions etc; a predictable, characteristic pattern of behavior, action, etc., that tends to occur under certain circumstances.

1535–1545: From the Medical Latin syndrome (a number of symptoms occurring together), from the Ancient Greek συνδρομή (sundromḗ) (concurrence of symptoms, concourse of people), from σύνδρομος (súndromos) (literally "running together" and often used in the sense of "place where several roads meet"), the construct being συν- (syn-) (with) + δρόμος (drómos) (a running, course), best understood as syn- + dramein + -ē (the feminine noun suffix).  The meaning, beginning in 1540s medical Latin, is thus derived from the Ancient Greek syndromos (place where several roads meet); the psychological sense emerging only in 1955.  Syndrome is a noun; the adjective is syndromic.  Synonyms include malady, problem, disorder, ailment, sickness, complaint, sign, complex, infirmity, affection, symptoms, diagnostics, prognostics, all of which tend, in varying degrees, also to be applied outside the medical context.

COVID-19

Art inspired by the pandemic caused by the COVID-19 syndrome, created by medical professionals: Outsized, Overwhelming Impact of COVID-19 by Lona Mody.

COVID-19 is a syndrome and the name allocated on 11 February 2020 by the World Health Organization (WHO) for the disease caused by the coronavirus SARS-CoV-2.  Although its origin remains most associated with Wuhan in late 2019, it may have been circulating earlier.  An acronym, COVID-19 stands for COronaVIrus Disease-2019 but the original working name for the virus causing the syndrome was 2019 novel coronavirus (2019-nCoV) which the International Committee on Taxonomy of Viruses (ICTV) changed to severe acute respiratory syndrome coronavirus (SARS-CoV-2).  The name is from the standard nomenclature of the discipline, chosen because the virus is a genetic cousin of the coronavirus which caused the SARS syndrome in 2002 (SARS-CoV).  The public tends not to distinguish between virus and syndrome, the popular names being Covid and corona.

Art inspired by the pandemic caused by the COVID-19 syndrome, created by medical professionals: Pipetting the Sample by Ali Al-Nasser.

First discovered in domestic poultry during the 1930s, coronaviruses cause a range of respiratory, gastrointestinal, liver, and neurologic diseases and are common in both humans and animals.  Only seven are known to cause disease in humans, four associated with the common cold; these have the catchy names 229E, OC43, NL63, and HUK1.  The three coronaviruses which cause serious lung infections (related to pneumonia) are SARS-CoV (Severe Acute Respiratory Syndrome) first noted in 2002, MERS-CoV (Middle East Respiratory Syndrome) which emerged in 2012 and SARS-CoV-2 (the COVID-19 pandemic).

Art inspired by the pandemic caused by the COVID-19 syndrome, created by medical professionals: Naturarte by Angela Araujo.

SARS-CoV, MERS-CoV and SARS-CoV-2 are zoonotic, beginning in an animal, transmitting, either directly or via another species, to people.  SARS-CoV-2 appears to be a mutated bat virus; bats host thousands of coronavirues and exist with them mostly in symbiotic harmony and it remains unclear whether the virus passed directly from bat to human or via some other creature.  Interestingly, while the nature of the COVID-19 syndrome hasn’t changed, the SARS-CoV-2 virus has mutated and now circulates in many strains, one tending to emerge as the dominant means of transmission in a given geographical area.  The dominance of the mutated strain happened because the mutation made the virus much more infectious so, in a classic example of Darwinian natural selection, the entity able more efficiently to multiply is the one which becomes dominant.  Despite early speculation, the mutation seems not to account for reductions in the COVID-19 death rate, a phenomenon virologists attribute to improved treatment the “harvesting effect”, meaning the virus first kills those easiest to kill.  There was also the effect of many dying early in the pandemic because health systems were overwhelmed and unable to provide the treatment which would have ensured their survival.  This has been noted in past wars, epidemics, pandemics and localized disasters.

Phage

Phage (pronounced feyj)

In microbiology & virology, a virus parasitic towards bacteria; a truncation of bacteriophage.

1917: from the Ancient Greek φάγος (phágos) (eater), from φαγ (phag), aorist (the tense of Greek verbs that most closely corresponds to the simple past in English) stem of ἐσθίω (esthíō) & ἔδω (édō) (to eat, to consume) and thus a combining form meaning “a thing that devours,” used in the formation of compound words, especially the names of phagocytes.  The noun bacteriophage (virus that parasitizes a bacterium by infecting it and reproducing inside it) was adopted in English in 1921, from the 1917 French original bactériophage, the construct being bacterio- (a combining form of bacteria) + -phage.

Some viruses can be helpful: A depiction of phages phaging.

Not all viruses are bad like SARS-CoV-2.  A bacteriophage, known almost always as a phage, is a virus which infects and replicates within bacteria.  Phages are composites of proteins that surround a DNA or RNA genome and may encode any number of genes from a handful to many hundreds.  Phages replicate within the bacterium following the injection of their genome into the target cytoplasm.  Phages exist naturally in the environment and are among the most common and diverse entities on earth.  Serious research began in several parts of Europe during the late nineteenth century and have been used for almost a century as anti-bacterial agents the former USSR and Central Europe.  In the West, phage therapy (using specific viruses to fight difficult bacterial infections) has been of interest for some time, attention heightened as the problem of antibiotic-resistant bacteria (superbugs in the popular imagination) began to grow in severity (the US Centers for Disease Control and Prevention (CDC) attributes one death every 15 minutes in the US to superbugs).  Since the discovery of penicillin, antibiotics have been used as a reliable cure for those suffering from once lethal bacterial infections but, over decades, a handful (compared with the trillions and trillions killed) of bacteria have proved resistant to antibiotics and as these survivors multiply, new infections emerge.  Historically this had prompted the development of revised or new antibiotics but the biological arms race has reached the point where some infections caused by called antibiotic resistant bacteria cannot be treated and for many other serious infections, the number of potent “last resort” antibiotics is dwindling.

Hence the interest in phages, a type of “friendly virus” which can be weaponized to fight even the most virulent and persistent bacterial infections.  Phages work as well as they do because viruses like the tiresome SARS-Cov-2 that makes humans sick, phages can infect only bacteria and are selective about which they target, a vital aspect of their role in medicine because human survival depends on the billions of bacteria in our bodies.  These phages are far from rare, existing in the natural environment almost everywhere on the planet and scientists conducting research find dirty waterways or damp, aerated, warm, decaying soil (both areas where high bacterial growth might be expected) are good places to collect samples.  The advantages phages offer are well known but there are also drawbacks and indeed some of the features of phages manifest as both.  For example, the great specificity of phages helpful in that they can be administered safely with the knowledge that no other organisms will be harmed but this can be a practical disadvantage in clinical medicine when it’s not known exactly which bacteria need to be targeted, which is why broad-spectrum antibiotics proved so effective at scale.  Being wholly natural, the shelf-life of phages is highly variable and there’s little experience in their administration beyond some communities in Eastern Europe where they’ve been part of medical practice for over a century.  Additionally, bacteria can develop resistance even to phages and one practical impediment to deployment not well recognized until recent years is that compared to chemical molecules, phages are quite big and there are sites in the human body which will be inaccessible.

Potential phage research subject:  In 2014, while on holiday in French Polynesia, Lindsay Lohan was infected with chikungunya, a virus spread by mosquitoes which causes debilitating joint pain and flu-like symptoms.  The World Health Organization (WHO) notes it was first identified in Africa in the 1950s and has since spread to the Indian Ocean region, southeast Asia and the Pacific islands, cases emerging for the first time in the Caribbean in 2013 while a small number have been reported in the US and Europe, mostly in travelers from affected areas.  The role of climate change in the geographical spread of Chikungunya has not been discounted and the symptoms include severe joint pain, headache, fever, nausea, fatigue and rash.  There is no cure or vaccine, and the illness can last from several days to as long as a few weeks, Ms Lohan advising all in susceptible regions to use bug spray and posted on Instagram a photo from the beach, captioned "I refuse to let a virus effect (sic) my peaceful vacation."

However, looming over the treatment of bacteriological infection is the economics of the pharmaceutical business (the big-pharma).  It was the ability in the twentieth century of the industry to mass-produce antibiotics at scale and at astonishingly low cost which meant what little research on phages was being undertaken was quickly abandoned; antibiotics truly were miracle drugs.  However, the economics which made antibiotics attractive to the public health community meant they added comparatively little to the profits of big-pharma compared with something lucrative like a blood-pressure drug which a patient would be required to take every day for the rest of their lives.  A cheap antibiotic, needed disproportionately in low-income countries was a less attractive path for the billions of dollars (and usually years of trials) required to bring a new drug to market.  What the industry likes are drugs which can be mass-produced to treat the “curse of plenty” diseases of first world customers.  Unless there’s some sort of molecular breakthrough (presumably at the level of DNA), phages seem likely for the foreseeable future to remain a niche treatment.

Little killing machines: Matt Cirigliano's graphical depiction of phages in action.

Pox

Pox (pronounced poks)

(1) In human & animal pathology, a disease characterized by multiple skin pustules, as smallpox, associated with the pockmarks left by the purulent skin eruptions.

(2) Historically, a reference to syphilis and sometimes to other venereal diseases (now called sexually transmitted diseases (STDs)) (archaic).

(3) In plant pathology, a disease of sweet potatoes, characterized by numerous pitlike lesions on the roots, caused by a fungus, Streptomyces ipomoea (also called soil rot and distinct from the condition root rot).

(4) In idiomatic use (usually as "a pox on (someone or something)"), an interjection to express distaste, rejection, aversion etc and thus a synonym of curse; the adjective poxy is a variation of the idea.

(5) As the acronym POx, variously Pulse Oximetry, Pressure Oxidation, Partial Oxidation, Point of Exit, Plain Old XML & Purgeable Organic Halogens.

(6) As the acronym POX (or PoX), proof of X.

Circa 1480s: A spelling variant of pocks, the plural of pock, from the plural of the Middle English pocke.  Pox in the sense of “a disease characterized by eruptive sores" emerged in the late fifteenth century, a spelling alteration of pocks & pockes (used since the late thirteenth century in this context), the plural forms of the Middle English pocke (pustule).  From the sixteenth century, it became the common word with which to refer to syphilis.  Pock (pustule raised on the surface of the body in an eruptive disease) was from the Middle English pok, from the Old English poc & pocc (pock; pustule; ulcer), from the Proto-Germanic pukkaz & pukkǭ (pock; swelling) and puh & puhh (to swell up; blow us), from the primitive Indo-European beu & bew- (to grow; swell).  It was cognate with the Middle Dutch pocke, the Dutch pok, the East Frisian pok, the dialectal German Pfoche, the Low German & German Pocke, the French pocque was also from Germanic sources.  The present participle is poxing and the past participle poxed; the noun plural is poxes.

As surnames, Pox & Pocks both long pre-dated the use in pathology and were of Germanic origin, recorded in Bavaria & Austria as a variant Of the Bavaria Böck) and the North German Beck (Baker).  Pox may in some cases have been an alternative spelling of these but is documented as a nickname for a “short man”, from the Low German Pōk (young child; Dwarf).  In some regions it may have been a Germanized form of both the Hungarian Pók and the Slovenian & Croatian Pok common in the Balkans.  In the US, Pox appears to have been an Americanized version of Pocks, most prevalent in the north-eastern states during the nineteenth century.

Coincidently, the Proto-Turkic bok means “dirt, dung” and was cognate with the Turkish bok & Chuvash пӑх (păh); in vulgar slang used predictably in the same sense as “shit” (solid excretory product evacuated from the bowel); the word persists in modern Azerbaijani.  The now idiomatic deprecatory adjective poxy entered English in the late nineteenth century as terms of distaste and disapprobation, having been in the medical literature sin 1853 in the sense of “infected with pox; pocked-marked”.

The noun pock-mark (pockmark later prevailed) dates from the 1670s and was used to describe “the scar or pit left by a pustule" after an infection, particularly after smallpox where the effects were most severe and it was noted as a verb & adjective after 1756.  The earlier word in this sense was the mid-fifteenth century pokbrokyn.  Pock-marked was used by astronomers to refer to the craters visible on the surface of the moon.

Cow-pox (also cowpox), was a disease of cattle, noted from the 1780s and the fluid of the vesicles made it transmissible to humans.  It played an important role in the history of inoculation because it was noted milkmaids (with much exposure to cowpox) enjoyed an almost complete immunity to smallpox.  Chicken-pox was first described circa 1730 and the name is thought either an allusion to the mildness of the condition (compared to syphilis (the pox) or smallpox) or it being most associated with children, or the resemblance of the lumps on the skin to chick-peas.  In medical Latin, the circa 1765 varicella (chicken-pox) was an irregular diminutive of variola, the adjectival form varicellous.  Smallpox, the acute, highly contagious disease and frequently (fatal in a quarter to a third of unvaccinated cases) deadly disease was first so named in the 1510s, as small pokkes, which distinguished the symptoms from the great pox (syphilis).

The famous exchange…

“You sir shall die either on the gallows or of the pox (ie from a STD)”.

“That sir, will depend on whether I embrace your principles or your mistress”.

.. has been attributed to many over the last two centuries odd so the ultimate source is uncertain but the first known record of what may anyway have been an apocryphal exchange appears to have been published in 1784 the London periodical The European Magazine.  Supposedly, protagonist and antagonist were the fourth Earl of Sandwich (1718-1792) and Samuel Foote (1720-1777) who met at a dinner held in his house by Sir Francis Blake Delaval. (1727–1771).

In the decades which followed, frequently the tale was re-told, sometimes with different participants (although Lord Sandwich was often named) and although occasionally embellished, what’s more interesting is that euphemisms and niceties were sometimes adopted; “the halter” replacing references to nooses and gallows and “p-x and “certain disease” substituting for pox.  Whether the changes reflected editorial taste or changes in what readers thought acceptable in print isn’t clear but by the early nineteenth century the anecdote was published with the punch-line but not the setup sentence.  That may however have been because, being well-known, by then a mere allusion was probably more funny still, a technique used to effect in the House of Commons as recently as 1968.  Whether or not the exchange ever happened or between who will never be known with certainty but the rejoinder is of such voltairesque quality it’s been attributed to more than half-a-dozen political notables.

Monkeypox

Little political energy could be summoned in the West to deal with climate change while it appeared to afflict only Africans, Arabs, Asians and animals (those inhabiting the places Mr Trump would have called “shithole countries”).  It took Europe & North America roasting, flooding and burning to focus minds.  Similarly, monkeypox (a zoonotic virus in the genus Orthopoxvirus) although for decades endemic in parts of Africa, attracted little interest in the West until outbreaks in 2022 and most people had probably never heard of it until a rapid spread of cases began to be reported in the UK, Europe and the US.  On 23 July 2022, the World Health Organization (WHO) declared the outbreak a Public Health Emergency of International Concern (PHEIC) with cases reported in 77 countries and territories, similar declaration in the past issued for Swine flu, polio, Ebola, Zika and Covid-19.

Monkeypox movement out of Africa 2022 tracked by the US Center for Disease Control (CDC).

Monkeypox gained its name in 1958 when scientists in Denmark isolated the virus in laboratory monkeys in 1958, when two outbreaks of the disease occurred in monkey colonies.  It’s since become clear that a number of rodents are much more efficient vectors of transmission and the virus is neither exclusive too nor most prevalent in monkey populations but, in the way of these things, the name stuck.  This is not a new phenomenon; the famous Spanish flu linked to the pandemic of 1918-1920 picked up the name only because cases there were reported in the press in 1918 whereas news of those already detected in the US, Europe and the UK were suppressed by wartime censorship which wasn’t applied in neutral Spain.  Another case is Rubella which came to be known as “German” measles, simply because it was scientists in that country which identified and first describe the cause and there are many more, most associated with countries not the source of the disease which bears the name.  It’s not known where and where a person first was infected but a human case of monkeypox was first documented in 1970 in the Democratic Republic of Congo (DRC) in 1970.  Since then, the DRC has always recorded the majority of infections although between then and 2022, it had spread to a number of African countries, cases beyond the continent rare until 2022.

Example of regional variations in reported transmission: Nigeria 2017-2022.

Other associations linked to the name monkeypox have also become controversial and the WHO announced it is to receive a new name, noting comments from scientists and public health officials that the current name is "discriminatory and stigmatizing" and it’s also inaccurate to name versions of the virus after parts of Africa.  Accordingly, the WHO has already renamed two clades (from the Ancient Greek κλάδος (kládos) (shoot, branch, family) of the virus to avoid the stigma associated with geographical names: The variant formerly known as “Congo Basin'' will now be referred to as “Clade I” and the “West Africa” variant will be known as “Clade II”.  The first suggestion of a new name is hMPXV, to denote the human version of the monkeypox virus and rather than anything geographic locations, letters and numbers should be used, based on order of discovery. In that system, the lineage behind the current international outbreak would be dubbed hMPXV-B1.  Some local authorities have acted preemptively, Chicago public health authorities for example using the bland “MPV”.  Whatever it ends up being called however, in the West, like COVID-19, monkeypox may be here to stay.

Take-off point of 2022 spread charted by the Lancet.

One aspect of the epidemiology of monkeypox in the West is that some 95% of those diagnosed are gay or bi-sexual men (“men who have sex with men” now the preferred and most accurate terminology).  Activists from the relative LGBTQQIAAOP faction are among those advocating a change of name although this is unlikely to remove the stigmatization based on the rate of transmission among men who have sex with men; presumably a stigmatization associated with hMPXV-B1 (or whatever) must be thought less offensive than one linked with monkeypox, probably because  an alpha-numeric string is a step removed from any link with animals and thus the slur of bestiality.  In the 1980s, that was one of the complaints once it was revealed HIV/AIDS was probably a mutated monkey virus from Africa and, even in the pre-internet era, unsubstantiated theories soon circulated that the entry of the virus into the human system was linked to men having sex with monkeys, a slur on both African men and the gay community who at the point constituted the bulk of infections, almost all as a result of sexual contact.  The consensus now is that HIV/AIDS entered human circulation (perhaps even as long ago as the nineteenth century) because of blood-blood mixing while monkeys were being butchered as part of the bush-meat trade.  The monkeypox vector may have been the same.

Naming virus species is the responsibility of the International Committee on the Taxonomy of Viruses (ICTV) (the expert group which brought us COVID-19) but the WHO has decided to ask for the public’s help, announcing an “…open consultation for a new disease name for monkeypox.  Anyone wishing to propose new names can do so”.  A portal will soon be provided.

Corona

Corona (pronounced kuh-roh-nuh)

(1) A white or colored circle or set of concentric circles of light seen around a luminous body.

(2) In meteorology, such a circle or set of circles having a small radius and ranging in color from blue inside to red outside, attributable to the diffraction caused by thin clouds, mist, or sometimes dust (distinguished from halo).

(3) In solar astronomy, a faintly luminous envelope outside of the sun's chromosphere, the inner part consisting of highly ionized elements; also called aureola & aureole.

(4) A long, straight, un-tapered cigar, rounded at the closed end.

(5) In botany, a crown-like appendage, especially one on the inner side of a corolla, as in the narcissus.

(6) In anatomy, the upper portion or crown of a part, as of the head.

(7) In architecture, the projecting, slab-like member of a classical cornice supported by the bed molding or by modillions, dentils, etc., and supporting the cymatium.

(8) The tonsure of a monk or other cleric.

(9) In ecclesiastical dress, a gold-colored stripe around the lower edge of a clerical headdress, as of a miter.

(10) A chandelier of wrought metal, having the form of one or more concentric hoops.

(11) In zoology, the head or upper surface of an animal, such as the body of an echinoid or the disc and arms of a crinoid.

(12) As Coronaviruses, a group of viruses which infect mammals and birds.  In humans, they cause usually mild (including 229E, the common cold) respiratory infections but forms such as SARS, MERS the famous COVID-19 can be lethal.

1555–1565: From the Latin corōna (garland, crown) from the Ancient Greek κορώνη (korṓnē or korōnis (crown, any curved object)), akin to korōnís (wreath; curved, beaked) & kórax (crow; raven); related was the Latin curvus (curved).  A doublet of crown, the plural forms are coronas & coronae.

COVID-19 and Coca-Cola

COVID-19 (an abbreviation of coronavirus disease 2019) was the name of the disease caused by SARS-CoV-2.  The name was adopted in February 2020, chosen by the World Health Organization (WHO) in partnership with the Committee on Taxonomy of Viruses; until then, variously it had been called 2019-nCoV, Novel coronavirus or Wuhan coronavirus.  SARS-CoV-2 is related to MERS-CoV (which causes Middle East respiratory syndrome (MERS)) and SARS-CoV (which causes severe acute respiratory syndrome (SARS)).

The Sun and its corona (left) and a depiction of the SARS-CoV-2 virus (bottom).

The class to which these viruses belong is called corona because, when viewed under an electron microscope, there’s a resemblance to the crown-like corona (the halo or ring of fire) around the Sun, seem when viewed through an appropriate telescope or other device.  The corona around the sun has long been known but viruses have been seen only since the development of the electron microscope because human viruses are very small, typically 100 nanometers (1 metre = 1,000 mm = 1,000,000 micrometres = 1,000,000,000 nanometres).  In the evolutionary timeline of life on earth, it's believed bacteria emerged quite some time before viruses.  Bacteria appear to have been one of the earliest forms of life and, because no evidence of life has yet been detected anywhere else in the universe, they're perhaps among the oldest anywhere.  Single-celled organisms with a relatively simple structure and capable of independent reproduction, bacteria are thought to have appeared some 3.5 to 3.8 billion years ago (the Earth dating back 4.5 billion) and the evidence suggests the viruses emerged 2-3 billions years ago.  Unlike bacteria, viruses are not considered living organisms in the traditional sense because they cannot carry out metabolic processes or reproduce on their own; instead, they are genetic material (DNA or RNA) enclosed in a protein coat.

As far as is known, all life forms now extant (and all extinct forms known) are descended ultimately from the one initial instance; life started once which means humans are related to cats, dogs, trees & bananas as well as to bacteria & viruses.  That makes people, bacteria and just about everything else vulnerable to infection by one virus or another, the consequences ranging from nothing to death but the behavior can also be used to advantage and a certain class of virus, the bacteriophage, after a long period of neglect during the antibiotic era, is attracting new interest.

Some viruses can be helpful: A depiction of bacteriophages phaging.

Not all viruses are bad like SARS-CoV-2.  A bacteriophage, known almost always as a phage, is a virus which infects and replicates within bacteria.  Phages are composites of proteins that surround a DNA or RNA genome and may encode any number of genes from a handful to many hundreds.  Phages replicate within the bacterium following the injection of their genome into the target cytoplasm.  Phages exist naturally in the environment and are among the most common and diverse entities on earth.  Serious research began in several parts of Europe during the late nineteenth century and have been used for almost a century as anti-bacterial agents the former USSR and Central Europe.  In the West, phage therapy (using specific viruses to fight difficult bacterial infections) has been of interest for some time, attention heightened as the problem of antibiotic-resistant bacteria (superbugs in the popular imagination) began to grow in severity (the US Centers for Disease Control and Prevention (CDC) attributes one death every 15 minutes in the US to superbugs).  Since the discovery of penicillin, antibiotics have been used as a reliable cure for those suffering from once lethal bacterial infections but, over decades, a handful (compared with the trillions and trillions killed) of bacteria have proved resistant to antibiotics and as these survivors multiply, new infections emerge.  Historically this had prompted the development of revised or new antibiotics but the biological arms race has reached the point where some infections caused by called antibiotic resistant bacteria cannot be treated and for many other serious infections, the number of potent “last resort” antibiotics is dwindling.

Hence the interest in phages, a type of “friendly virus” which can be weaponized to fight even the most virulent and persistent bacterial infections.  Phages work as well as they do because viruses like the tiresome SARS-Cov-2 that makes humans sick, phages can infect only bacteria and are selective about which they target, a vital aspect of their role in medicine because human survival depends on the billions of bacteria in our bodies.  These phages are far from rare, existing in the natural environment almost everywhere on the planet and scientists conducting research find dirty waterways or damp, aerated, warm, decaying soil (both areas where high bacterial growth might be expected) are good places to collect samples.  The advantages phages offer are well known but there are also drawbacks and indeed some of the features of phages manifest as both.  For example, the great specificity of phages helpful in that they can be administered safely with the knowledge that no other organisms will be harmed but this can be a practical disadvantage in clinical medicine when it’s not known exactly which bacteria need to be targeted, which is why broad-spectrum antibiotics proved so effective at scale.  Being wholly natural, the shelf-life of phages is highly variable and there’s little experience in their administration beyond some communities in Eastern Europe where they’ve been part of medical practice for over a century.  Additionally, bacteria can develop resistance even to phages and one practical impediment to deployment not well recognized until recent years is that compared to chemical molecules, phages are quite big and there are sites in the human body which will be inaccessible.

Electron micrograph of a Coronaviruses in colorized and in grey-scale.

The images captured from electron microscopes are always in black-and-white but are often artificially colored in the post-production process for better visualization and to assist with analysis.  Because of the resolution limit of the optical microscope, even at the highest magnification, viruses couldn’t be seen because their size meant they lay beyond the spectrum of visible light, the range of resolution being limited by the wavelength of the visible light that illuminates the specimen.  It was the resolution of the electron microscope, developed in the early 1930s, and able to offer an illumination with a wavelength much smaller than visible light which first made viruses visible.  An electron has the properties both of a particle and a wave so an electron’s wavelength is determined by its energy (or speed).  If an electron is accelerated to a speed of a million meters per second (circa 2.2 million mph (3.5 million km/h)) the physical wavelength is around one-tenth of a nanometer or about the size of an atom.  This permits an electron microscope to probe the structure of atoms in a crystal and thus see viruses.

Lindsay Lohan taking a 330ml lunch.

In February 2021, at a time when the official number of people with COVID-19 was around 107 million, mathematicians calculated all the COVID-19 causing SARS-COV-2 virus then circulating the planet easily would fit in a single (330ml) Coca-Cola can.  Using a model based on the viral load per currently infected victim (which varies during the duration of the infection), it was estimated there were at the time around two-hundred quadrillion (200 million billion or 2x10¹⁷). SARS-CoV-2 virus particles in the world.  Using that number, knowing the size of the virus, it was possible to calculate the total volume and even after accounting for the distinctive projecting spike proteins meaning the spherical particles will leave gaps when stacked together, the total is still less than the internal volume of the 330 millilitre can.

Two-hundred quadrillion is a really big number, there are said to be about that many grains of sand on the planet, but Sars-CoV-2 particles are really small, around a hundred nanometres (one nanometre is a billionth of a meter) so the radius of Sars-CoV-2 is roughly a thousand times thinner than a human hair.  The mathematicians multiplied the numbers, worked out the wastage of space caused by the troublesome spikes accounted for about a quarter of the total volume and concluded that in February 2021, the volume of SARS-CoV-2 in the world was 160 millilitres.  By mid-2021, cases had almost doubled so by then, either the can would be full or, given the margin of error associated with such calculations, a second can might be required.  The caveat to all this is that the math is based on the official number of infected people and nobody knows what the real is although all agree it will be higher but by what factor is guesswork, reliable data just not available to build a model.  Guesses have been proffered ranged from double to twenty times higher.  Depending on which of those is closest, a six-pack or a carton of cans might be filled.

Rare collector’s item: Lindsay Lohan MH Corona Extra tobacco card #480: US$5.00 on eBay.  Unrelated to this card is the specification of the corona cigars, straight-shaped cigars with rounded tops (the end taken to the lips) and defined by length: a corona about 5½ inches (140 mm) long; a petit corona (or corona chica) about 5 inches (125 mm) long, a tres petit corona about 4½ inches (115 mm) long & a half corona about 3¾ (95 mm) inches long.

The Toyota (Corona) 1600GT

1958 Toyota Corona "Van".

It was the Toyota Corona (1957-2001) which not only established the company in the vital US market but lent respectability to the very idea of the “Japanese car”, that term in the early 1960s not the by-word for quality and reliability it would in subsequent decades become.  Noting the success of the small (by US standards) Volkswagen Beetle and other imports, the company shipped a small number of Coronas to the US in the late 1950s but they were unsuitable for the environment (as indeed were a number of the diminutive European models which lacked the ruggedness of the VW) and interest was minimal, the Corona withdrawn from sale in 1960 although unsold models lingered on the lots for another year.

1966 "shovel-nose" Toyota Corona.

It was the third generation Corona, launched in September 1964 in an array of body styles, which was the Toyota passenger car to achieve international success, including in the US.  It was a thoroughly conventional design (ie mechanically a scaled down US sedan) with a body which was modern, inoffensive and practical although some thought the reverse-slanted nose strange.  It came to be nick-named the “shovel-nose” and proved ahead of its time, adopted in 1972 by Lancia for the Beta and in 1976 it appeared on Ford’s Escort RS2000 before variations of the shape eventually became the default for manufacturers seeking to eke out as much aerodynamic efficiency as possible.

The "shovel-nose" caught on: 1972 Lancia Beta (left) & 1976 Ford Escort RS2000 (right).  

The export range appeared in volume but the most desirable models were reserved for the JDM (Japanese domestic market), a long-standing, industry-wide practice which has had the effect of creating a minor export business for those who can satisfy the demand in markets like Australia, New Zealand & North America for the high-performance versions which have something of a cult-following.  The 1967 1600GT (or GT-5 for those with the optional five-speed gearbox) coupé (for this JDM “halo” model the Corona badge wasn’t used) was modest compared with some of the wild machinery which would appear in subsequent decades but by the standards of its time, there was some genuine sophistication.  The body was the standard two-door hardtop but the centrepiece was a double overhead camshaft (DOHC) cylinder head atop the 1600 cm³ four cylinder engine, the head designed by Yamaha which had also developed the one used on the straight-six in the exotic Toyota 2000 GT sports car made famous by the appearance of a custom built roadster version in the James Bond film You Only Live Twice (1967).

1967 Toyota 2000GT roadster.  Two 2000GT coupés were converted into roadsters for You Only Live Twice (one used for filming, the other a "back-up"), the work undertaken by Toyota’s special Toyopet Service Centre in Tsunashima.  The wire wheels were exclusive to the roadsters (15×5 inch magnesium wheels were used on the coupés) and the pair were very much movie props, neither vehicle fitted with side windows or a soft-top.  The "back-up car" is now on display in the Toyota Automobile Museum.

Known internally as the 9R, the 1600GT engine took a traditionally English approach to increasing power: twin carburetors, big valves and a high-compression ratio, the combination yielding a then impressive 110 horsepower at 6200rpm, the latter number something to note given the crankshaft was supported by only three main bearings.  Still, being a Toyota engine, reliability was solid and no history of bottom-end failure emerged; whether the unusual firing order (1243) had anything to do with this seems not to be discussed anywhere.  To cope with the new-found power, the Corona’s suspension was strengthened with re-calibrated springs and dampers along with two torque rods to locate the back axle.  That improved things but the Japanese manufacturers, although matching the Europeans in power, still had some way to go in achieving their dynamics; the 1600 GT was no cut-price Alfa Romeo.  It was though very well equipped, another lesson Toyota and other Japanese factories would (painfully) teach the West.  Always a low volume model, production of 1600 GTs totalled 2222, the last built late in 1968.

1967 Toyota 1600GT.  They were available also in red and white.

1974 Toyota Corona advertising.

The 1600GT's cult following notwithstanding, it really wasn't representative of the Coronas which went around the world and for decades provided owners and fleets with reliable, if uninspiring transport (very much the Camry of their time).  That made them memorable for many who may have enjoyed the charms of British, French or Italian machinery but found the quirks, oil-leaks, fragility or apparently insoluble issues electrical issues (often described as "gremlins") made ownership tiresome.  Toyota were aware of the advantage their approach (which put a premium on basic engineering and quality control over the finer points of handling and high-speed braking) and their advertising for the Corona in the 1970s said explicitly: "When your heart says Europe but your head says Japan".  People increasingly followed their heads and by 1989 Toyota released the Lexus, proving they were as good at building a Mercedes-Benz as they were at building Toyotas.  It took many attempts for Mercedes-Benz to become (almost) as good at building Toyotas.