Diagnosis & Prognosis

Diagnosis (pronounced dahy-uhg-noh-sis)

(1) In clinical medicine, the process of determining by examination the nature and circumstances of a diseased condition.

(2) The decision reached from such an examination; the abbreviation is Dx.

(3) In general use, a determining or analysis of the cause or nature of a problem or situation; an answer or solution to a problematic situation.

(4) In taxonomy (particularly in biology), a written description of a species or other taxon serving to distinguish that species from all others.  Historically, this was applied especially to a description written in Latin and published.

1675–85: A borrowing from the New Latin diagnōsis, from the Ancient Greek διάγνωσις (diágnōsis) (a distinguishing, means or power of discernment), from διαγιγνώσκω (diagignṓskō or diagignōskein (to distinguish; to discern (literally "to know thoroughly" or "know apart (from another)”)) from gignōskein (inquiry, investigation, knowing; come to know).  The construct was διά (diá) (through) + γιγνώσκω (gignṓskō) (to know).

The early precise meaning in medical Latin was “pre-scientific discrimination" applied especially in pathology, soon becoming a general "recognition of a disease from its symptoms".  The noun plural is diagnoses and derived forms include the nouns diagnostician & the rare (technical use only) prediagnosis (now more often as pre-diagnosis) and the adjective diagnostic.  One that probably should be more common than it appears, given the frequency with which it happens, is misdiagnosis.

Prognosis (pronounced prog-noh-sis)

(1) In clinical medicine, forecasting of the probable course and outcome of a disease, especially of the chances of recovery.

(2) In general use, a forecast or prognostication.

1645-1655: A borrowing from the Late Latin prognōsis, from the Ancient Greek πρόγνωσις (prógnōsis) (foreknowledge, perceiving beforehand, prediction), the construct being προ- (pro-) (before) + γνῶσις (gnôsis (gignōskein)) (inquiry, investigation, knowing; come to know), from γιγνώσκω (gignṓskō) (to know); the primitive Indo-European root was gno- (to know).  The general (non-medical) use in English dates from 1706 and there were (now rare) back-formations, the verb prognose noted in 1837 and the adjective prognostical as early as the 1680s.  In the Classical Latin prognostica meant "sign to forecast weather".

Prognostic (prognostick the obsolete spelling) & prognostication are nouns, prognosticable is an adjective, prognosticate is a verb.  From the Latin root English gained prognosis, French pronostic, German Prognose, Italian prognosi, Norman prog'nose (Jersey), Spanish pronóstico & Hungarian prognózis; in the invented international language of Esperanto, it is prognozo.

Clinical use

Prognosis is the companion word to diagnosis and the two are sometimes confused.  A diagnosis is an identification of a disease via examination or the result of some diagnostic test.  What follows is a prognosis, which is a prediction of the course of the disease as well as the treatment and results.  The schoolbook trick to remember the difference is (1) that a diagnosis comes before a prognosis, and diagnosis is before prognosis alphabetically and (2) diagnosis and detection both start with "d" whereas prognosis and prediction both start with "p".

Former US President Donald Trump was diagnosed with COVID-19 after a positive result to a test.  His prognosis was based on (1) what’s known generally about COVID-19 and (2) risk-factors specific to his case.  His risk factors included:

(1) Old: (74).

(2) Overweight (BMI 30+).

(3) Male (varies between countries but male death rate tends to be higher).

(4) He is sub-Human although, as a risk-factor, this remains speculative.  It’s mostly only some black Africans who are pure Humans; the rest of the world’s population is a sub-human mongrel blend, descendants of inter-breeding between humans and Neanderthals thousands of years ago.  It’s being hypnotized the unexpectedly good outcomes in sub-Saharan Africa during pandemic suggest some genetic advantage in being a pure Human; the research is not complete and there may be other factors (or some statistical quirk) but it is possible a genetic risk-factor related to the SARS-CoV-2 virus was inherited from archaic Neanderthals some sixty-thousand years ago.