Wednesday, September 2, 2020

Antediluvian

Antediluvian (pronounced an-tee-di-loo-vee-uhn)

(1) In biblical scholarship, of or belonging to the period before the biblical flood of Noah (Genesis chapters 6-9); a person who lived before the biblical great flood, particularly one of the biblical patriarchs (in some translations used as "prediluvian" which for all purposes is synonymous.

(2) In figurative use, anyone with attitudes though old-fashioned, or out of date, antiquated, primitive, outdated, outmoded, ancient, archaic, antique, superannuated, anachronistic, outworn, behind the times, medieval, quaint, old-fangled, obsolescent, obsolete, prehistoric, passé, fossilized etc; those views as held or expressed.

(3) In figurative use, someone very old (in use, an alternative to "Methuselian". 

(4) By extension (used loosely), of animals and plants: long extinct; prehistoric. 

1640-1650: The construct was the ante- (before (in the sense of "prior to in time")) + dīluvium (a flood) so understood as "the time before the great flood".  The ante- prefix was from the Latin preposition and prefix ante, from the primitive Indo-European hénti, locative singular of the root noun hent- (front, front side).  It was cognate with the Ancient Greek ντί (antí) (opposite, facing), the Old Armenian ընդ (ənd), the Tocharian Bānte, the English and, the Sanskrit अन्ति (anti), the Gothic and- & (in compounds) anda- & ōnd- and the German ant- & (in compounds) ent-.  The word was coined by English physician Sir Thomas Browne (1605-1682).  Dīluvium was from dīluō (to wash away), the construct being dis- (the prefix here used in the sense of "apart; tear asunder; in two) + lavō (to wash), from the primitive Indo-European lewh- (to wash) + -ium (the suffix used to form abstract nouns).  The use to refer to long extinct animals & plants began in orthodox science because it was once held all must have perished under the waters of the biblical flood.  The spelling antedeluvian is obsolete.  Antediluvian is a noun & adjective, antediluvianism is a noun, antediluvial is an adjective and antediluvially & antediluvianly are adverbs; the noun plural is antediluvians.

Handy adjective: politicians and others

Though sometimes casually treated as such, prehistoric and antediluvian are not synonyms.  Prehistoric has a precise (though culturally and geographically variable) meaning.  It means "before history was written down", hence before writing which emerged some five millennia ago in Mesopotamia.  Historians note the pivot has to be the creation of writing with some historic meaning and that earlier (usually financial) records don’t fulfil this criterion.  Representational forms predated writing, most famously as cave paintings, but these, while helpful in the interpretation of the archaeological record, don’t impart meaning and record events with the detail or accuracy inherent in the use of a written text.

Literal: The Subsiding of the Waters of the Deluge (1829), oil on canvas by Thomas Cole (1801-1848).

Antediluvian (before the flood) is a word from biblical scholarship.  Historically, it referred to the time prior to the biblical flood of Noah but in modern use it's used also of the notion of a monumental flood preserved in the folklore of a remarkable number of cultures although there is nothing in the geological record to suggest there was ever a global flood quite as described in the Old Testament.  Although usually used figuratively, for biblical-literalists (many of them south of the Mason-Dixon line), antediluvian means the actual time before the flood described in chapters 6–9 in the Book of Genesis.  The literalists invented their own field of study called "diluvial geology" (also labelled the "flood or creation geology") and regard the text in Genesis 6–9 as a scientific record; they date the great flood to within the last five thousand years.  The term is used also in the field of Assyriology for kings (those, according to the Sumerian king list, supposed to have reigned before the great flood).

Figurative: Scott Morrison (b 1968; Australian prime-minister 2018-2022, right ) showing an admiring Barnaby Joyce (b 1967; thrice (between local difficulties) deputy prime minister of Australia 2016-2022, left) a lump of coal (varnished by a dutiful staffer to avoid any dust from the little store of carbon), Parliament House, Canberra, February 2017.  Mr Morrison and Mr Joyce, for a variety of reasons, were doughty advocates of the burning of fossil fuels and great supports of the mining industry.

As a pejorative adjective, antediluvian is sometimes used figuratively although the choice is not always most appropriate.  "Ancient" is probably better to describe something old or "antiquated" if so old as to lack functionality; "Methuselan" (an allusion to Methuselah, the oldest person in the Hebrew Bible who lived an impressive 969 years) works best for those who seem perilously old.  The 2024 US presidential election looks Methuselaic because, in the style of 1964 when it was "crooked old Lyndon vs crazy old Barry, we'll be able to enjoy "sleazy old Donald vs senile old Joe".  Antediluvian is best reserved to describe the archaic or outdated views and opinions held by people, regardless of their age.  Mr Morrison (a fundamentalist Christian who, presumably, believes the flood happened exactly as described in the Book of Genesis) and Mr Joyce maintained their antediluvian attitudes to the burning of fossil fuels even when buried under the weight of their own absurdity.  In 2024, the Liberal party, now under new management, switched tactics and began to advocate the construction of multiple nuclear power-plants, opening a new theatre in the culture wars of energy policy.

Supporting the move away from burning fossils: Lindsay Lohan in Russia for the Formula R ePrix race, Moscow, June 2015.

On paper, while not without challenges, the country does enjoy certain advantages in making nuclear part of the energy mix: (1)  With abundant potential further to develop wind and solar generation, the nuclear plants would need only to provide the baseload power required when renewable sources were either inadequate or unavailable; (2) the country would be self-sufficient in raw uranium ore (although it has no enrichment capacity) and (3) the place is vast and geologically stable so in a rational world it would be nominated as the planet's repository of spent nuclear fuel and other waste.  The debate as it unfolds is likely to focus on other matters and nobody images any such plant can in the West be functioning in less than twenty-odd years (the Chinese Communist Party (CCP) gets things done much more quickly) so there's plenty of time to squabble and plenty of people anxious to join in.  Mr Joyce has with alacrity become a champion of all things nuclear (electricity, submarines and probably bombs although, publicly, he's never discussed the latter) and the National Party has never approved of solar panels and wind turbines because they associate them with feminism, seed-eating vegans, homosexuals and other symbols of all which is wrong with modern society.  While in his coal-black heart Mr Joyce's world view probably remains as antediluvian as ever, he can sniff the political wind in a country now beset by wildfires, floods and heatwaves and talks less of the beauty of burning fossil fuels.

Tuesday, September 1, 2020

Apotheosis

Apotheosis (pronounced uh-poth-ee-oh-sis (U) or ap-uh-thee-uh-sis (non-U))

(1) The elevation or exaltation of a person to the rank of a god.

(2) An example of an ideal; epitome; quintessence.

(3) The highest achievement of a person or institution.

(4) The highest point in the development of something; a culmination or climax.

(5) A glorified ideal; the realization of the apex or pinnacle (of a concept, construction or belief).

(6) In some Christian writings, a (sometimes blessed) release from earthly life, ascension to heaven; death; a technical synonym for the earthy death which precedes the soul rising to Heaven; the abbreviation in the texts was apoth.

(7) In psychology, the latent entity which mediates between a person's psyche and their thoughts (best known in the example of the id, ego and superego in Freudian psychology.

1570-1580: From the Late Latin apotheōsis (deification (especially of an emperor or royal personage)), from the Ancient Greek ἀποθέωσις (apothéōsis), from the verb ἀποθεόω (apotheóō) (to deify”).  The surface analysis apo- +‎ theo- +‎ -sis may be deconstructed as a factitive verb formed by the intensive prefix ἀπο- (apo-) + θεός (theós) (God) + -σις (-sis) (the suffix which formed nouns of action), the popular form in later Medieval texts being apotheoun (deify, make someone a god) and all forms were related to the primitive Indo-European root dhēs -, forming words for religious concepts which may have been an extension of the root dhe- (to set, put).  The verb apotheosize (exalt to godhood, deify) emerged circa 1760 and begat the inevitable apotheosized & apotheosizing, the extinct earlier (1670s) version being apotheose.  From the Late Latin & Church Latin other European languages picked up the word, the variations including the Catalan apoteosi, the French apothéose, the Galician apoteose, the Italian apoteosi, the Occitan apoteòsi, the Portuguese apoteose and the Spanish apotheosis.  Apotheosis is a noun, apotheosize is a verb and apotheotic is an adjective; the noun plural is apotheoses.

In the Roman Empire, apotheosis was a process whereby a dead ruler was declared divine by his successor.  Usually, the Senate passed a decree in accordance although, even at the time, it was often regarded a tawdry political trick by a new Emperor attempting to identify with a popular predecessor.  Time has not lessened the attraction for politicians and names like Reagan and Churchill are often invoked by those who'd like some of the lustre to reflect on them (although Mr Trump seems happy to mention only the more distant Washington and Lincoln).  Worse still was declaring divine a deceased dill: a work of satire attributed to the Stoic philosopher Seneca the Younger (Lucius Annaeus Seneca, circa 4 BC–65 AD) was The Apocolocyntosis (divi) Claudii (literally “The Pumpkinification of the divine Claudius”) which details the death of the Roman emperor Claudius and his judgement before the gods, the list of his crimes and failings so long that he’s cast down to the underworld.  Among scholars of Antiquity, there has been debate about whether Seneca really wrote the piece because among his many essays on politics, morality and philosophy, it’s the solitary satire and it’s thought he may have lent his name to give the piece some intellectual respectability.

Divas: Maria Callas (1923-1977), Chicago, 1955 (left), Lindsay Lohan (b 1986), Los Angeles, 2009 (centre) & Meghan, Duchess of Sussex (b 1981), London, 2018 (right).

An expired emperor's deceased loved ones could also be deified and posthumously, they were awarded the title Divus (or Diva if a women).  Classic Roman religion distinguished between a real god (of which the Romans had many) called deus and mortals defied through apotheosis who were called divus.  The label diva has long been used to describe highly-strung sopranos but in the modern age it’s applied also to pop-singers, reality-TV stars and the odd “difficult duchess”.  In Greek mythology there were mortals who became gods and many cultures embraced the idea, Hinduism by the million and most famously, until 1945 the Emperor was a “living God and the most honorable son of heaven”.  The three great monotheist faiths differ somewhat.  Islam is the clearest in that there is but one God in heaven and his greatest and final prophet was Muhammad (circa 570–632) who spoke through divine guidance but was flesh & blood.  In Judaism there is only one God and he has a special relationship with the Jews because of the covenant with them, the Jews believing (there are a few heretics however) that their Messiah has yet to appear on Earth but that day will come.  Christianity, predictably perhaps, is the most open to interpretation because of the notion of Jesus Christ as both earthy flesh & the second divine being of the Trinity (the Father, the Son and the Holy Ghost (Holy Spirit).  Thus, among Christian sects and cults which have come and gone, there's always been a bit of theological wriggle-room.

The Gullwing’s apotheosis

In the churning world of the collector car market, the ecosystem of the Mercedes-Benz 300 SL (W198) is noted for the benchmarks set in the prices for which they sell.  They were produced as both a coupé (1954-1957) with the memorable gullwing doors and a roadster (1957-1963) and in the context of the multi-million dollar used car business, were actually made in quite substantial numbers, some 1400 Gullwings and 1858 roadsters made.  One quirk of the 300 SL has always been that unusually, it’s the roadster which has always sold for less, such is the allure of those exotic doors.

1963 Mercedes-Benz 300 SL Roadster: US$3.7 million.

Unexpectedly, the orthodoxy was almost overturned.  In 2018, a 1963 300 SL Roadster with just 1372 km (852 miles) on the odometer attracted US$3.7 million at auction in France, making it the most expensive roadster ever sold, nudging the record (US$4.2) set in 2012 by a 1955 aluminum Gullwing.  It was well above expectations but even apart from it being barely used, it was an exceptional example because it came with both the factory hardtop and soft-top (still untouched in its original shipping crate) and, as one of the few dozen made in the last year of production, it included the all-aluminum engine and the notable (and overdue) addition of four-wheel disc brakes.  Another thing which would have attracted collectors is that based on the VIN (Vehicle Identification Number), just ten more were built before the line ended.

1955 Mercedes-Benz 300 SL (Weckerlé Alloy) : US$6.825 million.

However, the record didn’t last long because early in 2022, one of the twenty-nine aluminum-bodied Gullwings sold at auction in the US for US$6.825 million which does sound impressive but in what may be a sign of these troubled times, the bids actually failed to reach the estimates of US$7-8 million.  Long known as the Weckerlé Alloy because it was originally ordered by Joseph Weckerlé, the factory’s agent in Casablanca, the provenance of chassis 5500332 was close to impeccable, the 1955 car retaining its Sonderteile (special parts (NSL)) engine with tweaked fuel-injection and a more aggressive camshaft, gaining fifteen horsepower.  Additionally, it was fitted with the much admired Rudge knock-off wheels, the only deviations of note from the original Leichtmetallausführung (light-alloy design) specification being a replacement (1957) gearbox and glass windows which at sometime had replaced the thinner plexiglass units.  A newly trimmed, fitted-luggage set (something of a fetish in the Gullwing world) was also included.

1955 Mercedes-Benz 300 SLR (Uhlenhaut coupé): US$143 million.

Trumping all these results however was a world-record which not only set the mark for Gullwings but became the most expensive car ever sold.  In June, 2022, at a private auction conducted in the Mercedes-Benz factory museum in Stuttgart, one of the two 1955 300 SLR (W196S “Uhlenhaut”) coupés went under the hammer for US$143 million.  The 300 SLR (W196S) was a sports car, nine of which were built to contest the 1955 World Sportscar Championship.  Essentially the W196 Formula One car with a body and the straight-eight engine enlarged from 2.5 to 3.0 litres (152 to 183 cubic inches), the roadster is most famous for the run in the 1955 Mille Miglia in Italy which was won over a distance of 992 miles (1597 km) with an average speed of almost 100 mph (160 km/h); nothing like that has since been achieved.  There's infamy too attached to the 300 SLR; one being involved in the catastrophic crash and fire at Le Mans in 1955.  The two 300 SLR Gullwings were intended to be run in the 1955 Carrera Panamericana Mexico but were rendered instantly redundant when both the event and the Mercedes-Benz racing programme was cancelled after the Le Mans disaster.  The head of the competition department, Rudolf Uhlenhaut (1906-1989), added an external muffler to one of the coupés, registered it for road use (such things were once possible when the planet was a happier place) and used it for a while as his company car.  It was then the fastest road-car in the world, an English journalist recording a top speed of 183 mph (295 km/h) on a quiet stretch of autobahn but Uhlenhaut paid a price for the only partially effective muffler, needing hearing aids later in life.  So the relationship to the W198 road cars is distant but such is the resemblance the Uhlenhaut coupés have always been thought the Gullwing’s apotheosis.

Monday, August 31, 2020

Pizza

Pizza (pronounced peet-suh)

A flat, open-faced baked pie of Italian origin, consisting of a thin layer of bread dough topped with spiced tomato sauce and cheese, often garnished with anchovies, sausage slices, mushrooms etc and baked in a very hot oven; also called pizza pie.

Pre 1000: From the Modern Neapolitan Italian pizza (a variant of pitta (a flat bread)), the origin of which is uncertain.  Although unattested, it may be related to the Vulgar Latin picea, from the Classical Latin piceus (relating to pitch).  An alternative, and more likely, etymology traces it back to the Byzantine Greek πίτα (pita) (cake, pie) which exists in Modern Greek as pitta (cake), the ultimate root being the Ancient Greek ptea (bran) and pētítēs (bran; bread).  More speculative is the suggested link with the Langobardic (an ancient German language in northern Italy), from a Germanic source akin to the Old High German pizzo or bizzo (mouthful; morsel; bite) from the proto-Germanic biton (bit).

The first documented use of the word pizza appears to have been AD 997 in Gaeta and then later in different parts of Central and Southern Italy although it’s unclear whether it refers to something which would now be called a pizza.  The official Italian view remains that published in 1907 in the two volume Vocabolario Etimologico della Lingua Italiana (Etymological Vocabulary of the Italian language) that the origin lies in the dialectal pinza (clamp) from the Latin pinsere (to pound or stamp).  The word appears not to have entered general use in English use until the early 1800s although it was known, English linguist, poet & lexicographer John Florio (1552-1625; aka Giovanni Florio) included an entry in his Italian-English Dictionary (A Worlde of Wordes, or Dictionarie of the Italian and English tongues (1598)) defining pizza as “a small cake or wafer”.

Lindsay Lohan with slice of pizza.

The concept of a flat piece of bread dough, covered with savory toppings, is so obviously a convenient and economical way of preparing a meal using pre-modern technology that pizza-like dishes were probably included in the meals of many cultures, the cooking method doubtless quite ancient.  From Greek and Roman records it’s apparent it was known in antiquity a doubtless pre-dates even those civilizations, the Armenians famously having staked a claim to its invention but as part of modernity, it’s long been regarded as one of Italy’s many gifts to the world.  Within Italy, it’s the Neapolitans who most regard it as their own and some are quite proprietorial, appalled by some of the variations (especially those favored by English-speaking barbarians) which appear around the planet, the most infamous probably the ham and pineapple pizza, apparently a Canadian innovation from 1962.  The Neapolitans have allies in their battle for culinary hygiene, Iceland's president, Guðni Jóhannesson (b 1968, President of Iceland since 2016) in 2017 saying he’d like to ban pineapple on pizza.  He later confirmed to do so wasn’t within the constitutional authority of his office and admitted it wasn’t a desirable power of a head of state to possess.  Thinking it an abomination, the Neapolitans are probably more dictatorial and would ban it if they could, insisting that all may appear atop a pizza base is:

Plum tomatoes
Tomato puree (optional)
A sprinkling of table or sea salt
Freshly ground black pepper
Fresh Mozzarella balls
Parmesan cheese
A drizzle of Olive Oil
A hand-full of fresh basil leaves

The pizzeria (shop where pizzas are made, sold, or eaten) seems to have been a US coining, noted from 1928 in New York City, the number of restaurant using the name proliferating quickly there before spreading in the US and beyond.  In the 1920s and 1930s, “pizzeria” was used also to describe the dish itself.  The shortened for “za” was US student slang for pizza, two syllables just too much for the hippies of the time.

Crooked Hillary Clinton eating pizza: crookedly.

Pizzagate was a conspiracy theory that circulated during the 2016 US presidential campaign, sparked by WikiLeaks publishing a tranche of emails from within the Democrat Party machine.  According to some, encoded in the text of the emails was a series of messages between highly-placed members of the party who were involved in a pedophile ring, even detailing crooked Hillary Clinton’s part in the ritualistic sexual abuse of children in the basement of a certain pizzeria in Washington DC.  The named pizzeria didn’t actually have a basement but the story for a while caused a stir, later integrated (though with less specificity) into the cultural phenomenon which would next year emerge as QAnon.  QAnon may have started as satire in the wake of pizzagate, an absurdist parody of conspiracy theories with claims only simpletons would take seriously but it turned out there were a lot of them about and QAnon soon gained critical mass, assuming a life of its own.  What its rapid traction did suggest was those asserting something unbelievably evil or bizarre need only to claim crooked Hillary Clinton is in some way involved to make it sound creditable.  Had it not been for the perception of crooked Hillary's crooked crookedness, the whole QAnon thing may never have become a thing.

Donald Trump with Sarah Palin (b 1964; 2008 Republican vice presidential nominee), eating pizza with knife & fork.

The Italians (who should know), maintain the correct way to eat pizza is with a knife & fork, starting at the triangular tip and working towards the crust.  Only when what remains is a small remanent of crust, resistant to the prod of the fork, is it thought good form to pick it up with the fingers.  Folding, a popular recommendation among those concerned with cheese-loss, is also frowned upon.  In Italian a folded slice of pizza is known as a calzone (literally “stocking; trouser”) and even those should be eaten with knife & fork.

Donald Trump eating pizza, tip first.

Pizza etiquette is an inexact science but in the West there are few prepared to argue the correct technique is anything but some variation on holding it at the crust-end and eating from the tip although there are some bases so thin and floppy they defy any method short of being rolled into a sushi-like cylinder: for these it’s whatever works.  Generally though, hold the pizza by the crust and begin.  If it’s a thin base and droops towards the tip, lift it higher and lower the tip to the mouth; as the width of what’s left increases, structural integrity will improve and by at least half-way through, it’ll be rigid enough to be eaten horizontally.  Using the thumb, index and middle finger, the slice can slightly be curved (the edges raised) to prevent cheese or other topping sliding off.  In New York City, locals often insist this is called the “New York fold” but, having claimed authorship of the Martini (disputed) and the club sandwich (probably true), many assume if it’s in NYC, they own it.

Advertising agency BBDO's concept paper (3 August 1995) for Pizza Hut’s Stuffed Crust campaign (Donald & Ivana Trump).

Proving that Donald Trump (b 1946; US president 2017-2021) will do just about anything for money, in 1995 he and ex-wife (#1; the divorce granted in 1990) Ivana (née Zelníčková, 1949–2022)  starred in a commercial for Pizza Hut’s new “Stuffed Crust” pizza, encouraging consumers to eat the things “crust first”.   He knew it was wrong but did it anyway, something some critics suggest is an element in much of Mr Trump's conduct.

Recommended pizza toppings

Silverbeet, broccolini & mozzarella
Sweet potato, goat's cheese & pine nuts
Crab, roasted capsicum & pesto
Grilled aubergine (eggplant) & parmigiana
Blue cheese & roast pumpkin
Polenta, cheese & mushroom
Asparagus & artichoke pesto
Turkey, sticky onion & tart cranberry relish
Grilled aubergine (eggplant) & artichoke
Caramelized pineapple & bacon
Smoked salmon & brie
Pumpkin & zucchini with basil
Zucchini, capsicum & cashew
Gorgonzola, potato & bacon

Sunday, August 30, 2020

Phage

Phage (pronounced feyj)

In microbiology & virology, a virus parasitic towards bacteria; a truncation of bacteriophage.

1917: from the Ancient Greek φάγος (phágos) (eater), from φαγ (phag), aorist (the tense of Greek verbs that most closely corresponds to the simple past in English) stem of σθίω (esthíō) & δω (édō) (to eat, to consume) and thus a combining form meaning “a thing that devours,” used in the formation of compound words, especially the names of phagocytes.  The noun bacteriophage (virus that parasitizes a bacterium by infecting it and reproducing inside it) was adopted in English in 1921, from the 1917 French original bactériophage, the construct being bacterio- (a combining form of bacteria) + -phage.

Some viruses can be helpful: A depiction of phages phaging.

Not all viruses are bad like SARS-CoV-2.  A bacteriophage, known almost always as a phage, is a virus which infects and replicates within bacteria.  Phages are composites of proteins that surround a DNA or RNA genome and may encode any number of genes from a handful to many hundreds.  Phages replicate within the bacterium following the injection of their genome into the target cytoplasm.  Phages exist naturally in the environment and are among the most common and diverse entities on earth.  Serious research began in several parts of Europe during the late nineteenth century and have been used for almost a century as anti-bacterial agents the former USSR and Central Europe.  In the West, phage therapy (using specific viruses to fight difficult bacterial infections) has been of interest for some time, attention heightened as the problem of antibiotic-resistant bacteria (superbugs in the popular imagination) began to grow in severity (the US Centers for Disease Control and Prevention (CDC) attributes one death every 15 minutes in the US to superbugs).  Since the discovery of penicillin, antibiotics have been used as a reliable cure for those suffering from once lethal bacterial infections but, over decades, a handful (compared with the trillions and trillions killed) of bacteria have proved resistant to antibiotics and as these survivors multiply, new infections emerge.  Historically this had prompted the development of revised or new antibiotics but the biological arms race has reached the point where some infections caused by called antibiotic resistant bacteria cannot be treated and for many other serious infections, the number of potent “last resort” antibiotics is dwindling.

Hence the interest in phages, a type of “friendly virus” which can be weaponized to fight even the most virulent and persistent bacterial infections.  Phages work as well as they do because viruses like the tiresome SARS-Cov-2 that makes humans sick, phages can infect only bacteria and are selective about which they target, a vital aspect of their role in medicine because human survival depends on the billions of bacteria in our bodies.  These phages are far from rare, existing in the natural environment almost everywhere on the planet and scientists conducting research find dirty waterways or damp, aerated, warm, decaying soil (both areas where high bacterial growth might be expected) are good places to collect samples.  The advantages phages offer are well known but there are also drawbacks and indeed some of the features of phages manifest as both.  For example, the great specificity of phages helpful in that they can be administered safely with the knowledge that no other organisms will be harmed but this can be a practical disadvantage in clinical medicine when it’s not known exactly which bacteria need to be targeted, which is why broad-spectrum antibiotics proved so effective at scale.  Being wholly natural, the shelf-life of phages is highly variable and there’s little experience in their administration beyond some communities in Eastern Europe where they’ve been part of medical practice for over a century.  Additionally, bacteria can develop resistance even to phages and one practical impediment to deployment not well recognized until recent years is that compared to chemical molecules, phages are quite big and there are sites in the human body which will be inaccessible.

Potential phage research subject:  In 2014, while on holiday in French Polynesia, Lindsay Lohan was infected with chikungunya, a virus spread by mosquitoes which causes debilitating joint pain and flu-like symptoms.  The World Health Organization (WHO) notes it was first identified in Africa in the 1950s and has since spread to the Indian Ocean region, southeast Asia and the Pacific islands, cases emerging for the first time in the Caribbean in 2013 while a small number have been reported in the US and Europe, mostly in travelers from affected areas.  The role of climate change in the geographical spread of Chikungunya has not been discounted and the symptoms include severe joint pain, headache, fever, nausea, fatigue and rash.  There is no cure or vaccine, and the illness can last from several days to as long as a few weeks, Ms Lohan advising all in susceptible regions to use bug spray and posted on Instagram a photo from the beach, captioned "I refuse to let a virus effect (sic) my peaceful vacation."

However, looming over the treatment of bacteriological infection is the economics of the pharmaceutical business (the big-pharma).  It was the ability in the twentieth century of the industry to mass-produce antibiotics at scale and at astonishingly low cost which meant what little research on phages was being undertaken was quickly abandoned; antibiotics truly were miracle drugs.  However, the economics which made antibiotics attractive to the public health community meant they added comparatively little to the profits of big-pharma compared with something lucrative like a blood-pressure drug which a patient would be required to take every day for the rest of their lives.  A cheap antibiotic, needed disproportionately in low-income countries was a less attractive path for the billions of dollars (and usually years of trials) required to bring a new drug to market.  What the industry likes are drugs which can be mass-produced to treat the “curse of plenty” diseases of first world customers.  Unless there’s some sort of molecular breakthrough (presumably at the level of DNA), phages seem likely for the foreseeable future to remain a niche treatment.

Little killing machines: Matt Cirigliano's graphical depiction of phages in action.

Saturday, August 29, 2020

Galaxy

Galaxy (pronounced gal-uhk-see)

(1) In astronomy, a large system of stars, galactic dust, black holes etc, held together by mutual gravitation and isolated from similar systems by vast regions of space.  They exist (in at least the billions) as independent and coherent systems although because not static, can collide and merge.  Planet Earth is in a galaxy called the Milky Way.

(2) Figuratively, an assemblage of things or persons seen as luminous or brilliant.

(3) To gather together into a luminous whole (archaic).

(4) In mathematics, a hyper-real number in non-standard analysis

(5) In fashion or graphic design, any print or pattern reminiscent of a galaxy, constructed usually by blending semi-opaque patches of vibrant color on a dark background.

(6) The Milky Way, the apparent band of concentrated stars which appears in the night sky over earth (now long obsolete and used only in historic reference).

1350–1400: From the Middle English galaxyë, galaxie & galaxias from the Old French galaxie and Medieval Latin galaxia & galaxias (the Milky Way; in the classical Latin via lactea or circulus lacteus), from the Ancient Greek γαλαξίας (galaxías kyklos) (milky circle) from γάλα (gala (genitive galaktos)) (milk) and related to the Latin lac (milk)), from the primitive Indo-European g(a)lag (milk).  Galaxy is a noun and verb, the adjective is galactic the noun plural galaxies; the present participle is galaxying and the past participle galaxied.)  The technical astronomical sense as it’s now understood as a discrete stellar aggregate including the sun and all visible stars emerged as a theory by 1848, the final scientific proof being delivered in the 1920s; the figurative sense of "brilliant assembly of persons or articles" dates from the 1580s.

It will all end badly

The Milky Way, planet Earth’s cosmic suburb was in the late fourteenth century defined as "the galaxy as seen in the night sky", and was a loan-translation of Latin via lacteal which had existed formerly in the Middle English as milky Wey, Milken-Way & Milky Cercle.  The philosophers (natural scientists) of antiquity had speculated on the nature of what they could see when gazing at night sky and some (Democrates, Pythagoras (and even the historian Ovid)) guessed they were looking at a vast array of stars, the matter when Galileo, using his telescope, reported that the whole vista was resolvable into stars and it attracted other names including Jacob's Ladder, the Way to St James's, and Watling Street.

Artist's impression of the Milky Way generated by the Chinese Academy of Sciences, 2019.

The Milky Way was originally thought the entire universe but as telescopes improved astronomers by the mid nineteenth century speculated that some of the spiral nebulae they observed were actually vast and immensely distant structures perhaps similar in size and shape to the Milky Way but the proof of that wasn’t definitive until the 1920s.  Galaxies are held together by the gravitational attraction of the material within them, most coalescing around a nucleus into elliptical or spiral forms although a few are irregular in shape.  Galaxies range in diameter from hundreds to hundreds of thousands of light-years and contain between a few million and several trillion stars, many grouped into clusters, with these often parts of larger super-clusters.

Lindsay Lohan Samsung Galaxy S24 phone case.

German philosopher Immanuel Kant (1724–1804) was among the first to theorize the Milky Way was not the only galaxy in the universe and coined the term “island universe to describe a galaxy”.  Kant was right and while estimates vary, over one hundred-billion galaxies exist in the observable universe, most of which are moving away from our Milky Way; those farther away receding faster than those nearby.  The Milky Way rotates at about 560,000 mph (900,000 km/h) and completes a full revolution about every two-hundred million years, thus one galactic revolution ago, dinosaurs roamed the Earth.  In about four billion years, the Milky Way will begin a slow-motion (in astronomical terms) collision with the Andromeda galaxy, a process which will take at least one hundred million years.  Optimistically, astronomers have suggested the ellipsoidal result be named Milkomeda.

Notable Ford Galaxies, 1959-1970

Initially to augment their range-topping Fairlane, Ford adopted the Galaxie name in 1959 as a marketing ploy to take advantage of public interest in the space race, using the French spelling to add a touch of the exotic.  On the full-sized platform, the name was used until 1974 but it was the brief era of the charismatic high-performance versions built in the early-mid 1960s which are most remembered;  already a force on US circuits, they became also in England, Australia, South Africa & New Zealand, one of the more improbably successful racing cars.  The Galaxie was notable also as the platform which Ford used to create the LTD, essentially a Galaxie bundled with a number of otherwise optional features and some additional appointments, sold at an attractive price.  It was an immediate success and had two side effects, (1) other manufacturers soon used the same tactic, creating most notably the Chevrolet Caprice and (2) the creation of "a luxury Ford" began the process of rendering the Mercury brand, introduced in 1938 as "the luxury Ford", eventually redundant.  In an evolution which would play-out over two decades, the interior fittings of the Ford LTD and its competitors would become increasingly ornate although critics were sometimes divided on the aesthetic success of the result.  A generation after the name was retired in the US, Ford in Europe used the anglicized spelling, in 1995 introducing the Galaxy, a dreary family van.

1959 Ford Galaxie Skyliner.

The Galaxie was a mid-year addition to the line, assuming the role of the top-of-the-range model from the Fairlane 500, a position it would occupy until 1965 when it began to be usurped by the LTD, added that year as a Galaxie option although it would later become a separate model which would outlast the Galaxie by more than a decade.  Best remembered from the 1959 range was the Skyliner, a two-door convertible with the novelty of a retractable hard-top a marvel of analogue-era engineering, the operation of the all-steel apparatus a mesmerizing piece of mechanical choreography from the early space-age, controlled by three drive motors, ten solenoids, many relays & circuit breakers, all connected with a reputed 610 feet (186 m) of electrical cabling.  Despite the intricacy, it proved a reliable system.

1960 Ford Galaxie Starliner.

As the 1960s dawned, the muscle car thing was still years away, the intermediate and pony-cars on which they would be based not yet in production and by choice, Ford probably wouldn’t have produced any high performance versions of the Galaxie.  For some time, Detroit had been putting more powerful versions of their biggest engines into their top-line models but these tended to be early interpretations of what would later come to be known as the “personal car”, heavyweight coupés laden with power accessories, air conditioning and luxury fittings but those big engines were increasingly and extensively being modified by those seeking competitive advantage in what rapidly had become the wildly popular racing series run by the National Association for Stock Car Auto Racing (NASCAR).  With some alarm, the sanctioning body, concerned both at the extent to which the cars being used differed from their “stock car” concept and the high speeds being attained, imposed rules designed to restrict the use of components used on the track to those genuinely available to customers.  Thus was born the 352 cubic inch (5.8 litre) (FE) “Special” V8, a US$204.70 option available on all 1960 Fords except the wagons although, reflecting the intended market, niceties like air conditioning, power steering and power brakes weren’t available.  Rated at 360 (268 kW) horsepower, the 352 Special actually out-powered the 430 cubic inch (7.0 litre) (MEL) V8, which, at 350 horsepower (261 kW), was available in the Thunderbird but was so bulky and heavy that its use on the track had been curtailed although it would enjoy some success in powerboat racing.  The 352 Special also provided quite a jump in performance from other 352s which offered a (standard) 235 horsepower (175 kW) or 300 (224 kW) in the 352 Super, neither exactly sparkling performers although typical for the era; a Special-equipped Galaxie managing a standing quarter-mile five seconds quicker than a Super, admittedly one hampered by one of Ford’s early, inefficient automatic transmissions.  The 352 Super wasn’t available for long but the streamlined Starliner body to which most of them were fitted proved to have aerodynamic properties close to idea for use on NASCAR’s ovals but public enthusiasm for the style soon waned and it was replaced by something thought more elegant but which proved less slippery, inducing Ford to try (unsuccessfully) one of the more blatant cheats of the era and one which would prove to be the first shot in what came to be called the “aero-wars”.

1961 Ford Galaxie.

The power-race had for a while been raging on the ovals but NASCAR’s rules dictating all the bits be available for public sale and produced in sufficient number to make purchase genuinely possible meant the race moved to the showroom and thus, public roads, something which produced a remarkable generation of cars but which would have implications for the public, the industry and, ominously, the laws which would follow.  Facing competition with more power and displacement, Ford in 1961 released a version of the new 390 cubic inch (FE) (6.5 litre) this time with an induction system which used three two-barrel carburetors rather than the single four barrel which had sat atop the 352 Special.  Strangely, most owners had to go a circuitous route to get their six-barrel 390, few assembled that way by the factory, the cars instead delivered equipped with a high-performance version of the 390 which included in the trunk (boot), a kit with the parts and accessories to upgrade from the supplied single four barrel carburetor to a triple, two barrel apparatus.  Intended for installation by the dealer, thus equipped, power jumped from 375 horsepower (280 kW) to 401 (299 kW).

1962 Ford Galaxie 406 (replica).

The power race however was accelerating faster than the vehicles it inspired and in 1962, the Galaxie’s new high-performance engine was a 406 cubic inch (FE) (6.6 litre) V8, offered either with a single four-barrel carburetor and rated at 385 horsepower (287 kW) or a 405 horsepower (302 kW) version with the triple two-barrel Holleys.  The 406 certainly delivered increased power but the internal stresses this imposed, coupled with effects of the higher speeds now possible exposed weaknesses in some aspects of underlying engineering, some components being subject to forces never envisaged in the late 1950s when the design was finalized.  The most obvious and frequent failure afflicted the main (bottom-end) bearings and, part-way during the production run, change was made to add a second set of bolts to secure the main-bearing caps, the novelty being that they were drilled sideways, entering through the skirt of the block, thus gaining the moniker “cross-bolted”.

Ford Galaxie 427s, Brands Hatch, 1963.

The 406 however had a production life of less than two years, replaced in 1963 by a the 427 cubic inch (FE) V8, an engine which would be offered in so many configurations that the stated power ratings were more indicative than calculated but the versions available for the street versions of the Galaxie were rated at 410 horsepower (360 kW) if fitted with a single four barrel carburetor and 425 (317 kW) if running a pair.  The 427 would go on to a storied and decorated history on the street, strip and circuit including twice winning the 24 hour classic at Le Mans but unexpectedly, it had a successful career in saloon car racing in England, Australia, South Africa and New Zealand.  Predicted at the time to be briefly fast, loud and spectacular before its hunger for brake linings and tyres ended its outings, it instead proved competitive, stable and reliable, dominating the 1963 British Saloon Car Championship, ending the reign of the 3.8 litre Jaguars.  In the US however, although the 427 had powered the Galaxie to trophy winning successes in the 1964 NASCAR season, the larger displacement had further increased internal pressures and reliability issues with the bottom end had again been encountered.  The cross-bolting had solved the issues caused by vibration but now the lubrication was proving inadequate, the oiling system setup to first to lubricate the top end and then to the crankshaft.  The solution was another oil galley along the side of the block, delivering priority lubrication to the bottom end; introduced in 1965 as a running change, these engines came to be known as “side-oilers”, the earlier versions retrospectively known as “top oilers”.

1966 Galaxie 7 Litre.

By 1966, the era of the Galaxie as a race car was nearly over, Ford finding the Lotus Cortina and the Mustang quicker on tighter circuits while on the big NASCAR ovals, the race teams during the year switched from the full-sized cars to the intermediates, the Fairlane (the name re-applied to a smaller vehicle after 1962) now the platform of choice.  In 1966 & 1967, the 427 remained available but demand was muted, the two-door Galaxie gaining an option called "7 Litre" (they really did use the French spelling (presumably to avoid a linguistic clash with "Galaxie") and the choice was between the 427 (noisy, cantankerous, an oil burner, expensive and powerful) or the 428 (mild-mannered, smooth, quiet & cheap) and the market spoke, the sales breakdown between the 427/428 in 1966/1967 being 11035/38 and 1056/12.  The message was clear; there were many who wanted high-performance cars but fewer and fewer wanted the package in a big machine, the attention of the market now focused on the intermediates and pony cars.

1970 Ford XL.

By 1970, except for a run heavy-duty units for police fleets which used the old 428, for its top-line option, the full-sized range switched to the new 429 cubic inch (385) (7.0 litre) V8, designed with emission control systems in mind, which had for a couple of seasons been offered in the Thunderbird.  Although available in a version rated at 360 horsepower (265 kW) which was rather more convincing than the perhaps optimistic numbers granted to some of the 428s used in the earlier Galaxies, the emphasis was now on effortlessness rather than outright performance although, Ford was the last of the big three still to offer a four-speed manual gearbox in the big cars and the option lasted until 1970 although the deletion from the option list must have been a late change because while brochures printed for that year’s range included it, it seems none were built.  Actually, technically, by then such things were no longer Galaxies, the two-doors after 1967 called just the “Ford XL” although everyone seemed still to call them Galaxies and for those who still lusted for the way full-size things used to be done, Plymouth did offer their triple carburetor 440 cubic (7.2 litre) inch V8 but only with an automatic transmission.  It would last only until 1971.