Saturday, March 25, 2023

Esurient

Esurient (pronounced ih-soo-r-ee-uhnt)

(1) The state of being hungry; greedy; voracious.

(2) One who is hungry.

1665–1675: A borrowing from the Latin ēsurient & ēsurientem, stem of ēsuriēns (hungering), present participle of ēsurīre (to be hungry; to hunger for something), from edere (to eat), the construct being ēsur- (hunger) + -ens (the Latin adjectival suffix which appeared in English as –ent (and –ant, –aunt etc) and in Old French as –ent).  The form ēsuriō was a desiderative verb from edō (to eat), ultimately from the primitive Indo-European hédti (to eat and from the root ed-) + -turiō (the suffix indicating a desire for an action).  English offers a goodly grab of alternatives including rapacious, ravenous, gluttonous, hoggish, insatiable, unappeasable, ravening, avaricious, avid and covetous.  Esurient is a noun & adjective, esurience & esuriency are nouns and esuriently is an adverb; the noun plural is esurients.

A noted Instagram influencer assuaging her esurience.

For word-nerds to note, a long vowel in the Proto-Italic edō from the primitive Indo-European hédti is illustrative of the application of Lachmann's law (a long-disputed phonological sound rule for Latin named after German philologist and critic Karl Lachmann (1793–1851)).  According to Lachmann, vowels in Latin lengthen before primitive (and the later proto-) Indo-European voiced stops which are followed by another (unvoiced) stop.  Given the paucity of documentary evidence, much work in this field is essentially educated guesswork and Lachmann’s conclusions were derived from analogy and the selective application of theory.  Not all in this highly specialized area of structural linguistics agreed and arguments percolated until an incendiary paper in 1965 assaulted analogy as an explanatory tool in historical linguistics, triggering a decade-long squabble.  This polemical episode appeared to suggest Lachmann had constructed a framework onto which extreme positions could be mapped, one wishing to attribute almost everything to analogy, the other, nothing.  With that, debate seemed to end and Lachmann’s law seems now noted less for what it was than for what it was not.

In memory of Tenuate Dospan

A seemingly permanent condition of late modernity is weight gain; the companion permanent desire being weight loss.  The human propensity to store fat was a product of natural selection, those who possessed the genes which passed on the traits more likely to achieve sexual maturity and thus be able to procreate.  Storing fat meant that in times of plenty, weight was gained which could be used as a source of energy in times of scarcity and for thousands of generations this was how almost all humans lived.  However, in so much of the world people now live in a permanent state of plenty and one in which that plenty (fats, salt & sugars) doesn’t have to be hunted, gathered or harvested.  Now, with only a minimal expenditure of energy, we take what we want from the shelf or, barely having to move from our chair, it’s delivered to our door.  In our sedentary lives we thus expend much less energy but our brains remain hard-wired to seek out the fats, salt & sugars which best enable the body to accumulate fat for the lean times.  Some call this the "curse of plenty".

For all but a few genetically unlucky souls, the theory of weight loss is simple: reduce energy intake and increase the energy burn.  For many reasons however the practices required to execute the theory can be difficult although much evidence does suggest that once started, exercise does become easier because (1) the brain rewards the body for doing it with what’s effectively a true “recreational drug”, (2) it becomes literally easier because weight-loss in itself reduces the energy required and (3) the psychological encouragement of success (some dieticians actually recommend scales with a digital read-out so progress can be measured in 100 gram (3½ oz) increments).  Still, even starting is clearly an obstacle which is why the pharmaceutical industry saw such potential in finding the means to reduce supply (food intake) if increasing demand (exercise) was just too hard.

Lindsay Lohan about to assuage her esurience.

For centuries physicians and apothecaries had been aware of the appetite suppressing qualities of various herbs and other preparations but these were usually seen as something undesirable and were often a side effect of the early medicines, many of which were of dubious benefit, some little short of poison.  Although the noun anorectic (a back formation from the adjective anorectic (anorectous an archaic form) appeared in the medical literature in the early nineteenth century, it was used to describe a patient suffering a loss of appetite; only later would it come to be applied to drugs, firstly those which induced the condition as a side-effect and later, those designed for purpose.  The adjective anorectic (characterized by want of appetite) appeared first in 1832 and was a coining of medical Latin, from the Ancient Greek ἀνόρεκτος (anórektos) (without appetite), the construct being ἀν- (an-) (not, without) + ὀρέγω (orégō) (a verbal adjective of oregein (to long for, desire) which was later to influence the word anorexia)).  The noun was first used in 1913.

Tenuate Dospan.  As an industry leader in promoting DEI (diversity, equity and inclusion), Merrell was years ahead in the use of plus-size models.

In the twentieth century, as modern chemistry emerged, anorectic drugs became available by accident as medical amphetamines reached the black market as stimulants, the side effects quickly noted.  Those side effects however were of little interest to the various military authorities which during World War II (1939-1945) made them available to troops by the million, their stimulant properties and the ability to keep soldiers alert and awake for days at a time functioning as an extraordinary force-multiplier.  Not for years was fully it understood just how significant was the supply of the amphetamine Pervitin in the Wehrmacht’s (the German armed forces (1935-1945)) extraordinary military successes in 1939-1941.  In the post-war years, various types of amphetamine were made commercially available as appetite suppressants and while effective, the side effects were of concern although many products remained available in the West well into the twenty-first century.  Probably the best known class of these was amfepramone (or diethylpropion) marketed most famously as Tenuate Dospan which was popular with (1) those who wanted to be thin and (2) those who wanted to stay awake longer than is usually recommended.  Tenuate Dospan usually achieved both.

The regulatory authorities however moved to ensure the supply of Tenuate Dospan and related preparations was restricted, the concern said to be about the side effects although in these matters the true motivations can sometimes be obscure.  In their place, the industry responded with appetite suppressants which essentially didn’t work (compared with the efficient Tennuate Dospan) but sold for two or three times the price which must have pleased some.  The interest in restricting esurience however continued and one of the latest generation is Liraglutide (sold under various the brand names including Victoza & Saxenda) which started life as an anti-diabetic medication, the appetite suppressing properties noted during clinical trials, rather as the side-effects of Viagra (sildenafil) came as a pleasing surprise to the manufacturer.  Being a injection, Liraglutide is harder to use than Tenuate Dospan (which was a daily pill) and users report there are both similarities and differences between the two.

Liraglutide (Saxenda).  The dose increases month by month.

On Tenuate Dospan, one’s appetite diminished rapidly but food still tasted much the same, only the desire for it declined and being an amphetamine, energy levels were elevated and there were the usual difficulties (sleeping, dryness in the mouth, mood swings).  Dieticians recommended combining Tenuate Dospan with a high quality diet (the usual fruit, vegetables, clear fluids etc).  By contrast, although Liraglutide users reported much the same loss of interest in food, they noted also some distaste for the foods they had once so enjoyed and a distinct lack of energy.  It’s still early in the life of Liraglutide but it certainly seems to work as an appetite suppressant although in the trials, the persistent problem of all such drugs was noted: as soon as the treatment ceased, the food cravings returned.  Liraglutide does what the manufacturer’s explanatory notes suggest it does: it is a drug which can be used to treat chronic obesity by achieving weight-loss over several months, during which a patient should seek to achieve a permanent lifestyle change (diet and exercise).  It does not undo thousands of generations of evolution.  The early literature at least hinted Liraglutide was intended for obese adolescents for whom no other weight loss programmes had proved effective but anecdotal evidence suggests adults are numerous among the early adopters.

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