Efficacy

Efficacy (pronounced ef-i-kuh-see)

(1) A capacity for producing a desired result or effect; effectiveness; an ability to produce a desired effect under ideal testing conditions.

(2) The quality of being successful in producing an intended result; effectiveness; a measure of the degree of ability to produce a desired effect.

1520-1530: From the Old French efficace (quality of being effectual, producing the desired effect), from the Late Latin efficācia (efficacy), from efficāx (powerful, effectual, efficient), genitive efficacis (powerful, effective), from stem of efficere (work out, accomplish).  In eleventh century English, in much the same sense was efficace from the Old French eficace from the same Latin root efficācia; there was also the early fifteenth century efficacite from the Latin efficacitatem.  The sixteenth century adjective efficacious (certain to have the desired effect) was often used of medicines (presumably a favorite of apothecaries), the construct being the Latin efficaci-, stem of efficax from the stem of efficere (work out, accomplish)  + -ous.  The –ous suffix was from the Middle English -ous, from the Old French –ous & -eux, from the Latin -ōsus (full, full of); a doublet of -ose in an unstressed position.  It was used to form adjectives from nouns, to denote possession or presence of a quality in any degree, commonly in abundance.  In chemistry, it has a specific technical application, used in the nomenclature to name chemical compounds in which a specified chemical element has a lower oxidation number than in the equivalent compound whose name ends in the suffix -ic.  For example, sulphuric acid (H₂SO₄) has more oxygen atoms per molecule than sulphurous acid (H₂SO₃).  The noun inefficacy (want of force or virtue to produce the desired effect) dates from the 1610s, from the Late Latin inefficacia, from inefficacem (nominative inefficax), the construct being in- (not, opposite of) + efficax.

The most familiar related form in modern use is efficacious but in general use this is often used in a more nuanced way than the pass/fail dichotomy of "efficacy" familiar in medical trials.  In general use, efficacious is a "spectrum word" which describes degrees of the ameliorative effects of treatments although while the comparative is "more efficacious", a more common form is "quite efficacious"; the superlative "most efficacious" appears to be popular among the small subset of the population who use efficacious at all.  Efficacy, efficacity & efficaciousness are nouns, effectuate is a verb, effectual & efficacious are adjectives and efficaciously is an adverb; the noun plural is efficacies.

Clinical trials in the pharmaceutical industry

In the development of vaccines (and medicinal drugs in general), efficacy trials (sometimes called phase III or explanatory trials) determine the percentage reduction of disease in a vaccinated group of people compared to an unvaccinated group, under the most favorable conditions, which is with the subjects housed in a hospital equipped to handle intensive care patients.  Conducted on human subjects if tests on animals proved satisfactory, it’s a purely clinical exercise, practiced since 1915 and can be done as a double-blind, randomized study if no safety concerns exist.  One potentially distorting aspect of both efficacy and (particularly) safety trials is a historic bias towards healthy young males as the subjects.  The antonym of the adjective efficacious is inefficacious but the word is rarely used when drug trials produce unsatisfactory results: the punchier "failed" is almost always used.  Under normal circumstances, the testing process can take many years, the industry usually referring to trials as phases:

Phase I: Safety Trial

Phase I trials are done to test a new biomedical intervention for the first time in a small group of people (typically 20-100) to evaluate safety.  Essentially, this determines the safe dosage range and identifies side effects.

Phase II: Efficacy Trial

Phase II trials are done to study an intervention in a larger group of people (several hundred or more depending on the product) to determine efficacy (ie whether it works as intended) and further to evaluate safety.

Phase III: Clinical Study

Phase III studies are done to study the efficacy of an intervention in large groups of trial participants (often thousands) by comparing the intervention to other standard or experimental interventions (or to non-interventional standard care).  Phase III studies are also used to monitor adverse effects and to collect information that will allow the intervention to be used safely.

Phase IV: Efficiency Study

Phase IV studies are done after the drug has been released and is being prescribed.  These studies are designed to monitor the effectiveness of the approved intervention in the general population and to collect information about any adverse effects associated with widespread use over longer periods of time.  They may also be used to investigate the potential use of the intervention in a different condition, or in combination with other therapies.

Proven efficacy: Adderall.

Adderall and Mydayis are trade names for a combination drug called mixed amphetamine salts (a mix of four salts of amphetamine).  In all Western jurisdictions  Belonging to a class of drugs known as stimulants, Adderall is a prescription medication and it contains two active ingredients: the amphetamines and dextroamphetamine.  As a prescribed medicine, primarily Adderall is used in the treatment of attention deficit hyperactivity disorder (ADHD), a neurobehavioral disorder characterized by symptoms such as inattention, hyperactivity, and impulsivity.  Adderall works by increasing the levels of certain neurotransmitters (most critically dopamine and norepinephrine) in the brain, these both mechanisms which play some role in regulating attention, focus, and impulse control.  Beyond ADHD, Adderall is sometimes prescribed off-label for the treatment of narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden, unpredictable episodes of sleep.

Adderall also has something of a cult following among those who seek to experience some of its more desirable side-effects.  Like many of the earlier amphetamines (most famously Tenuate Dospan (diethylpropion or amfepramone) an appetite suppressant of legendary efficacy), Adderall can assist in weight-loss and can safely be used for this by most people but because of its potential for dependence, it should be taken (for whatever purpose) only under clinical supervision.  For those prescribed Adderall, in some circumstances, it may continue to be taken (at the prescribed level) even if one is in a substance rehabilitation facility as was the case in 2013 when Lindsay Lohan completed a 48-hour drug detox at the Betty Ford Clinic in Indio, California.  Ms Lohan was prescribed Adderall after being diagnosed with ADHD but the standard protocol used by rehab clinics is that doctors routinely re-evaluate (1) the ADHA diagnosis and (2) the efficacy of the treatment regime.  Depending on their findings, doctors can prescribe alternative drugs or cease drug intervention entirely.  Ms Lohan was quoted as saying she’d been using Adderall "for years" and that she cannot function without it and her choice of rehab facility was once which would permit both smoking (tobacco) and the use of Adderall.

As she earlier explained it: “I have severe ADD. I can’t stand still.  So, I take Adderall for that; it calms me.”  Ms Lohan further noted she was not unaware there were those who took Adderall for its side-effects, notably weight loss or the ability to function effectively for extended durations without needing to sleep but that she wasn’t someone who needed to regulate her weight and that her sleeping patterns were normal.  However, the cult if anything is growing and in the US shortages of Adderall were reported (not for the first time) in late 2022.  The US Food and Drug Administration (FDA) responded by issuing a statement noting that while there was nothing unusual about episodic shortages of generic drugs at any given time because the profit margins are low and production is sometimes restricted to avoid a sacrifice in the opportunity cost vis-a-vis higher margin products, Adderall was “a special case because it is a controlled substance and the amount available for prescription is controlled by the Drug Enforcement Administration (DEA).”  The FDA added that because there had been “a tremendous increase in prescribing” because of virtual medicine (e-consultations) and a general trend towards over-prescribing and over-diagnosing, the periodic shortages were likely to continue.  THE FDA’s conclusion was that “if only those who needed these drugs got them, there probably wouldn't be a [stimulant medication] shortage” but the diagnosis of ADHD continues to grow and the desire for rapid weight-loss solutions remains strong.

Thermidor

Thermidor (pronounced thur-mi-dawr or ter-mee-dawr (French))

(1) In the French Revolutionary calendar, the eleventh month of the year (19 (or 20) July to 17 (or 18) August); it was also called Fervidor (both terms now only of historic interest).

(2) As Thermidorian Reaction, a counterrevolution or coup d'état in some way recalling the events in Paris in July 1794.

(3) As lobster thermidor (both elements sometimes capitalized), a method of preparing the unfortunate crustacean for consumption.

Borrowed from French thermidor, from the Ancient Greek θέρμη (thérmē) (hot; heat) + δῶρον (dôron) (gift), the construct thus construct being thérm(ē) + (i) + dôr(on).  Thermidor is a noun & proper noun, thermion is a noun, thermidorien & thermidorian are nouns & adjective and thermionic is an adjective; the noun plural is thermidors.

In the history of revolutionary France, the noun thermidorian is used to refer to (1) a member of the politically moderate (a relative term) group who participated in the events of the 9th Thermidor (27 July 1794) and (2) a supporter of the reactionary movement following the coup d'état.  The use in political discourse was named after the play Thermidor (1891) by Victorien Sardou (1831–1908), itself named for the eleventh month of the French Republican Calendar.  The Coup d'état of 9 Thermidor (remembered in many reports as “the Fall of Maximilien Robespierre” (1758–1794)) was triggered by Robespierre's address to the National Convention on 26 July 1794), a speech which prompted his arrest the next day and his death on the guillotine the day after.  Due process is a quick business in revolutionary times.  Robespierre’s fateful words included a reference to “internal enemies, conspirators, and calumniators” within revolutionary movement but he declined to name names, giving rise among his colleagues to fears he was plotting another great purge of their numbers.

Comrade Stalin (left), an ice axe (centre) and comrade Trotsky (right).

Comrade Leon Trotsky (1879-1940; founder of the Fourth International) in The Revolution Betrayed: What Is the Soviet Union and Where Is It Going? (1936) had a feeling for the political phrase and labelled the state created by Comrade Joseph Stalin (1878-1953; Soviet leader 1924-1953) a “Soviet Thermidor” because although Tsarist era capitalism wasn’t re-created (a la the monarchy in France not being restored in the 1790s), the combination of a bureaucracy supporting a personality cult (even if the latter was in 1936 still somewhat disguised) was “a counterrevolutionary regression” which betrayed what was achieved by comrade Vladimir Lenin (1870–1924; head of government of Russia or Soviet Union 1917-1924) between 1917-1924.  The phrase caught the imagination of many, notably those in the Partido Obrero de Unificación Marxista (The POUM, the Workers' Party of Marxist Unification), a non-Communist Marxist party (a surprisingly populated fork of left-wing thought) which Stalin correctly associated with Trotskyism.  The POUM was highly productive in thought but drifted increasingly far from the moorings of political reality although rhetoric which included polemics like “Stalinist Thermidorians have established in Russia the bureaucratic regime of a poisoned dictator.”  Agents of the Narodný komissariat vnutrennih del (NKVD, The People's Commissariat for Internal Affairs and one of the many predecessors to the KGB), answerable only to comrade Stalin, killed dozens of POUM’s Central Committee which ended the organization’s effectiveness for a generation.  Comrade Stalin filed away in his memory annoying phrases and in 1940 he had comrade Trotsky murdered in Mexico.  The murder weapon was an ice-axe.

Lobster Thermidor

Lobster Thermidor is a creamy, cheesy mixture of cooked lobster meat, egg yolks, and cognac or sherry, stuffed into a lobster shell and served usually with a an oven-browned cheese crust.  In restaurants, it’s an expensive dish because lobsters are now high-priced (there was a time when they were eaten almost only by the working class) but especially because it’s something with a high labor component.  Cooked at home, without the need to charge out labor, it’s a form of extravagance on a budget and it’s a favorite among the dinner party set and the ideal thing to serve as a prelude to discussions about house prices.

Ingredients

2 lobsters
2 tablespoons unsalted butter
2 tablespoons minced shallots
½ teaspoon minced garlic
2 tablespoons all-purpose flour
2 tablespoons cognac or brandy
¾ cup milk
¼ cup heavy cream
¾ teaspoon sea salt
¼ teaspoon ground white pepper
½ cup finely grated Parmesan, plus 2 tablespoons
1 tablespoon dry mustard powder
1 tablespoon finely chopped fresh tarragon leaves
2 teaspoons finely chopped parsley, plus additional for garnish
¼ cup shredded gruyere cheese

Lobster Thermidor is a signature dish at Texas-based Prime Steak & Seafood and their web-site includes photographs to encourage bookings.

Instructions (cooking lobster)

(1) Fill a large, deep stock pot with about 3-4 inches (75-100 mm) of water and add enough sea-salt to make it as salty as sea-water.  Some add aromatics like herbs or lemon to enhance the flavor but thermidor purists insist thing shouldn’t be done and that all such work must be done by the sauce.  Only ever cook live lobsters.  If this is not practical, pre-cooked lobsters are available.

 (2) Once the water has been brought to the boil, add the lobsters (head first) to the pot.  Steaming is the best way to cook lobster because the meat becomes less waterlogged and less flavor in lost to the liquid.

(3) Cover tightly and steam lobsters for 8 minutes per pound (.454 kg), for the first pound and then an additional 3 minutes per pound.  Thus, if the total weight being cooked is 2 lb, cooking time will be about 10 minutes.

(4) Using tongs, remove lobsters from the pot and check to ensure they are cooked.  A fully cooked lobster will register 135-140˚F (57-60˚C) when a quick-read thermometer is inserted into the thickest part of the tail (always insert device into the tail’s underside).

Instructions (lobster thermidor)

(5) Preheat oven to 375˚F (190˚C).

(6) Line a baking sheet with aluminium foil and set aside.

(7) Cut lobsters in half (length-wise and a sharp blade will be needed) and remove the tail meat.

(8) Gently twist claws from the body and gently crack with the back of a heavy knife to remove the meat.  Gently pull the front legs from the shell and discard (some retain them for decorative purposes.

(9) Chop the tail meat and claw meat into bite sized pieces and set aside.

(10) Place the halved lobster shells on the baking sheet and set aside.

(11) Melt butter in a deep skillet over medium heat.  Add shallots and garlic, stirring, until fragrant (about 30 seconds).  Add the flour and whisk to combine.

(12) Cook the flour mixture, stirring constantly to make a light roux (approximately 2 minutes).

(13) Add cognac and cook for 10 seconds, stirring constantly.

(14) Slowly add milk, stirring constantly until combined.  Bring to a boil, reduce the heat, and simmer until thick enough to coat the back of a spoon (approximately 2-3 minutes).

(15) Slowly add cream, stirring constantly, until thoroughly combined.  Continue cooking while stirring over medium heat for 1 minute (done correctly, this will have produced a very thick mix.  Season with salt and pepper.

(16) Remove from heat and stir in the parmesan cheese, mustard, tarragon, and parsley.  Fold in the lobster meat.

(17) Divide the mixture among the lobster shells and place stuffed side up on a clean baking sheet.

(18) Sprinkle the top of each lobster with the gruyere and broil until the top is golden brown (should take 5-6 minutes).

(19) Place 1 lobster half on each plate, garnish with additional parsley, and serve immediately.

Lindsay Lohan rescues a lobster from the ice, saving it from becoming lobster thermidor (the crustacean’s ultimate fate is unknown).  Lohan Beach Club, 2019.

Syllabus

Syllabus (pronounce sil-a-bis)

(1) In the Roman Catholic Church, a formally issued list.

(2) In education, a summary of topics which will be covered during an academic course, or a text or lecture.

(3) In law reports, the headnote of a reported case containing a summary of the the points of law determined, prefixed to a reported case.

1650s: From the Medieval Latin syllabus (list) which actually arose as a misprint, its accusative plural syllabos appearing in place of sittybas (or perhaps sittubas) in an edition of Cicero's Ad Atticum (Letters to Atticus), printed during the 1470s.  The corrupt form was influenced by the stem of the Ancient Greek συλλαμβάνω (sullambánō) (put together), source of σῠλλᾰβή (sullabḗ) (syllable); the true etymon is σιττύβα (sittúba) (parchment label; table of contents”) of unknown origin.  As was not unknown with medieval errors of transcription, the name stuck and it too came to mean "a label for a papyrus roll" before morphing into its current usual meaning (an outline or other brief statement of the main points of a discourse, the subjects of a course of lectures, the contents of a curriculum), a shift established by the mid seventeenth century.  Had it been a real word, the proper plural would be syllabi.  Syllabus is a noun; the noun plural is syllabi or syllabuses.

Mean Girls (2004): Now on the syllabus.

Since the 1980s, there has been criticism of some of the more novel courses which have appeared on University syllabuses.  While there has always been something of a hierarchy in the perception of the intellectual robustness demanded by various courses (physics, engineering and such higher on most pecking orders than social work, media studies, gender studies et al) such has been the emergence of what’s regarded as academic promiscuity (some say prefer prostitution) that the term “Mickey Mouse courses” was coined to describe some of the newest entries.  The use of “Mickey Mouse” as a pejorative is an example of dysphemism (an expression with connotations derogatory either about the subject matter or to the audience) and was from the French dysphémisme, modelled on euphémisme (euphemism), modified by the substitution of the prefix dys-, from the Ancient Greek δυσ- (dus-) (expressing the idea of difficulty, or bad status).  Interestingly, in Australia, “Mickey Mouse” was also used as a slang form meaning “very good”, apparently as a form of rhyming slang (“Jack Lang in the local parlance”) based on “full house”, a most desirable hand in poker.  The use operated as late as the 1960s in parallel with “Mickey Mouse” meaning “poor quality” attributed to the cheap, unreliable (and fake) Mickey Mouse watches which were sold in great quantity during World War II (1939-1945).

In some cases, the criticism is probably unfair because university economics departments coining the term “Swiftonomics” to describe the micro-economic effect on regional economies of Taylor Swift’s (b 1989) tour seems something most suitable for students to study.  It would be the ideal template as a case study; not only does her tour have a beginning, a middle and an end but it would offer something onto which could be mapped most of the tools of social and economic analysis including the dreaded econometrics which most of us regard as having “a marginal propensity to confuse”.  Boston’s Northeastern University is taking Swiftonomics most seriously.  At least the reaction to the announcement of Swiftonomics wasn’t as cruel as a course in the sociological importance of football being dismissed as “David Beckham studies” and something designed to attract enrolments from paying students rather than a “real” course of study.

Mean Girls has appeared on a number of syllabuses and objectively, there’s no reason why the same tools of deconstruction and analysis used of any of the texts more traditionally part of university course shouldn’t be used and Mean Girls content has been noted in fields such as media studies, cultural studies, gender studies and film studies.  In 2015, Colorado College attracted attention for offered a Mean Girls themed class in which 13 students could gain credits for exploring the "motives behind why women seek authority and the actions they are willing to take in order to hold onto it."  Once can see why the department choose Mean Girls to dissect that sort of realpolitik and the course included structural comparisons with tales from Greek mythology.  Those who are snobby about the so-called “Mickey Mouse” courses on syllabuses and blame it on a decline in standards should recall astrology and alchemy once appeared on the degree rolls of many respectable institutions.

Pius IX, modernity and the Syllabus of Errors

Thou shalt not: Pope Pius IX

Most famous syllabus to emerge from the Vatican was that issued by Pope Pius IX (Giovanni Maria Mastai Ferretti, 1792–1878; pope 1846-1878) in 1864 as Syllabus Errorum (Syllabus of Errors), a usefully comprehensive list of the faults of modernity in which His Holiness listed eighty propositions he condemned erroneous.  Though controversial, even today, it is by the standards of the Holy See a pleasingly brief document and defines a coherent world-view in a few pages; some subsequent pronouncements from Rome have been more verbose and said less.  The pontificate of Pius IX remains the longest in history.  Since the election of Pope Francis (b 1936; pope since 2013), Pius IX has attracted a new audience of admirers, in the curia and beyond.  This is at least in part because of the certainty of his positions and the unambiguity in his words.  His most memorable quotes are succinct:

Liberal Catholics are the worst enemies of the Church.  If a future Pope teaches anything contrary to the Catholic Faith, do not follow him.

However, there can be consequences for those who decide not to follow a pope thought to be teaching things “contrary to the Catholic faith”.  In November 2023, it was announced Pope Francis had sacked (“removed from the pastoral care of the diocese” as the Holy See puts such things) US Bishop Joseph Strickland (b 1958; Bishop of the Diocese of Tyler, Texas 2012-2023) and appointed an interim apostolic administrator.  Whether related or not, the announcement was made only a couple of days after the Vatican’s Dicastery for the Doctrine of the Faith (the DDF, the latest name for the Inquisition) issued a statement confirming an adult who identifies as transgender can receive the sacrament of Baptism under the same conditions as any adult, as long as “there is no risk of causing scandal or confusion to other Catholics”.  To clarify the matter, the DDF added that children or adolescents experiencing transgender identity issues may also receive Baptism “if well prepared and willing”.  This remarkable statement was one of several answers to sacrament-based questions relating to those who identify as transgender or are in same-sex relationships which were generated in response to questions to the DDF posed in July 2023 by Bishop José Negri (b 1959; Bishop of Santo Amaro, Sao Paulo, Brazil since 2015).  All such statements from the Vatican (especially those which in any way touch on LGBTQQIAAOP issues) must be assessed as part of the pope’s response to the recent sessions of the Synod on Synodality and of great interest was the response about whether transgender-identifying people or those in homosexual relationships (1) can be godparents or (2) witness a marriage and (3) whether children adopted or born through assisted reproduction to same-sex couples can be baptised.  To that last matter the DDF quoted the relevant section of the Code of Canon law, saying “For the child to be baptised there must be a well-founded hope that he or she will be educated in the Catholic religion”.  Lambeth Palace would have been proud of a fudge like that but it anyway means transgender-identifying people can be baptized and witness marriages.

Bishop Strickland (appointed to his position in 2012 by Benedict XVI (1927–2022; pope 2005-2013, pope emeritus 2013-2022)) is said to be one of the WWJD (what would Jesus do?) school and on 12 May 2023 had tweeted (ie to the whole world) “I believe Pope Francis is the pope, but it is time for me to say that I reject his program of undermining the Deposit of Faith.  Follow Jesus."  It would have been a nice touch had he’d added “Follow Pius IX” but he resisted that temptation.  The tweet was enough for the Vatican to launch an investigation, in response to which on more than one occasion Bishop Strickland asserted he would not voluntarily resign.  The investigation was remarkably quick by the standards of the Holy See and early in November a spokesman for the Archdiocese of Galveston-Houston revealed the tribunal had advised His Holiness “the continuation in office of Bishop Strickland was not feasible.”  The pope requested the bishop resign but he declined, thus the rare sacking.

In many ways, it’s not the sacking (though rare) which is remarkable but that it took so long to happen.  Strickland had long argued the Roman Catholic Church has become “weak” under Francis and openly challenged the pope to dismiss him, something which observers of the Vatican suspect might have happened some time ago had not Benedict lived as long as he did.  Just to make sure however, shortly after Benedict was entombed, Strickland re-tweeted a video which condemned Francis as a “diabolically disoriented clown” but despite that, he was quoted as blaming the dismissal on his refusal to implement one of Francis’ progressive reforms restricting the old Latin Mass.  An issue which quietly has been simmering since Second Vatican Council (Vatican II; 1962-1965 (which Strickland probably regards as heretical)) Strickland insisted the Latin rituals must remain “because I can’t starve out part of my flock", adding, “I feel very much at peace in the Lord and the truth that he died for.”

Nor is Strickland without support because early in his pontificate, some theologians and cardinals went dangerously close to accusing Francis of being a heretic and after the sacking, perhaps sniffing blood, the editor of The Remnant (a most traditional Catholic newspaper) took to X (formerly known as Twitter) called the firing “total war”, adding “Francis is a clear and present danger not only to Catholics the world over but also to the whole world itself."   No doubt he agreed with Strickland who tweeted: “Rejoice always that…no matter what the day brings Jesus Christ is the Way, the Truth and the Life, yesterday, today and forever. May the saints and the Blessed Virgin Mary always inspire us to return to Christ no matter how we may wander into darkness. Jesus is Light from Light."  That is a WWJD motif: “Where there is darkness, Jesus will make the light”.

Francis has certainly become more assertive since the death of Benedict, condemning the “backwardness” of some conservative Catholic leaders (notably in Germany and the US), saying what they believed in was “not faith but political ideology” and that Church doctrine on issues like abortion and same-sex marriage can change.  Changing something with two thousand-odd years of inertia and institutional memory won’t be easy but Francis has the priceless advantage enjoyed by probably no other head of government or state currently in office: he sits atop a theocracy as an absolute sovereign, whatever he says, goes; he has the last word.  Interestingly, whenever some matter is clearly contentious, he does increasingly mention the word “doctrine”, conscious no doubt that he and everybody else knows that if he chooses to speak ex cathedra, that invokes papal infallibility and means not only is his ruling final but that objections may no longer be even discussed.  Defined dogmatically under Pius IX at the First Vatican Council (Vatican I; 1869–1870 (although it was then claimed it had actually existed and been acknowledged for over a thousand years), no pope has spoken ex cathedra since Pius XII (1876-1958; pope 1939-1958) in 1950 but for Francis it remains his thermo-nuclear option.

The Syllaus of Errors, Pope Pius IX, 1864

I. PANTHEISM, NATURALISM AND ABSOLUTE RATIONALISM

1. There exists no Supreme, all-wise, all-provident Divine Being, distinct from the universe, and God is identical with the nature of things, and is, therefore, subject to changes. In effect, God is produced in man and in the world, and all things are God and have the very substance of God, and God is one and the same thing with the world, and, therefore, spirit with matter, necessity with liberty, good with evil, justice with injustice. -- Allocution "Maxima quidem," June 9, 1862.

2. All action of God upon man and the world is to be denied. -- Ibid.

3. Human reason, without any reference whatsoever to God, is the sole arbiter of truth and falsehood, and of good and evil; it is law to itself, and suffices, by its natural force, to secure the welfare of men and of nations. -- Ibid.

4. All the truths of religion proceed from the innate strength of human reason; hence reason is the ultimate standard by which man can and ought to arrive at the knowledge of all truths of every kind. -- Ibid. and Encyclical "Qui pluribus," Nov. 9, 1846, etc.

5. Divine revelation is imperfect, and therefore subject to a continual and indefinite progress, corresponding with the advancement of human reason. -- Ibid.

6. The faith of Christ is in opposition to human reason and divine revelation not only is not useful, but is even hurtful to the perfection of man. -- Ibid.

7. The prophecies and miracles set forth and recorded in the Sacred Scriptures are the fiction of poets, and the mysteries of the Christian faith the result of philosophical investigations. In the books of the Old and the New Testament there are contained mythical inventions, and Jesus Christ is Himself a myth.

II. MODERATE RATIONALISM

8. As human reason is placed on a level with religion itself, so theological must be treated in the same manner as philosophical sciences. -- Allocution "Singulari quadam," Dec. 9, 1854.

9. All the dogmas of the Christian religion are indiscriminately the object of natural science or philosophy, and human reason, enlightened solely in an historical way, is able, by its own natural strength and principles, to attain to the true science of even the most abstruse dogmas; provided only that such dogmas be proposed to reason itself as its object. -- Letters to the Archbishop of Munich, "Gravissimas inter," Dec. 11, 1862, and "Tuas libenter," Dec. 21, 1863.

10. As the philosopher is one thing, and philosophy another, so it is the right and duty of the philosopher to subject himself to the authority which he shall have proved to be true; but philosophy neither can nor ought to submit to any such authority. -- Ibid., Dec. 11, 1862.

11. The Church not only ought never to pass judgment on philosophy, but ought to tolerate the errors of philosophy, leaving it to correct itself. -- Ibid., Dec. 21, 1863.

12. The decrees of the Apostolic See and of the Roman congregations impede the true progress of science. -- Ibid.

13. The method and principles by which the old scholastic doctors cultivated theology are no longer suitable to the demands of our times and to the progress of the sciences. -- Ibid.

14. Philosophy is to be treated without taking any account of supernatural revelation. -- Ibid.

III. INDIFFERENTISM, LATITUDINARIANISM

15. Every man is free to embrace and profess that religion which, guided by the light of reason, he shall consider true. -- Allocution "Maxima quidem," June 9, 1862; Damnatio "Multiplices inter," June 10, 1851.

16. Man may, in the observance of any religion whatever, find the way of eternal salvation, and arrive at eternal salvation. -- Encyclical "Qui pluribus," Nov. 9, 1846.

17. Good hope at least is to be entertained of the eternal salvation of all those who are not at all in the true Church of Christ. -- Encyclical "Quanto conficiamur," Aug. 10, 1863, etc.

18. Protestantism is nothing more than another form of the same true Christian religion, in which form it is given to please God equally as in the Catholic Church. -- Encyclical "Noscitis," Dec. 8, 1849.

IV. SOCIALISM, COMMUNISM, SECRET SOCIETIES, BIBLICAL SOCIETIES, CLERICO-LIBERAL SOCIETIES

Pests of this kind are frequently reprobated in the severest terms in the Encyclical "Qui pluribus," Nov. 9, 1846, Allocution "Quibus quantisque," April 20, 1849, Encyclical "Noscitis et nobiscum," Dec. 8, 1849, Allocution "Singulari quadam," Dec. 9, 1854, Encyclical "Quanto conficiamur," Aug. 10, 1863.

V. ERRORS CONCERNING THE CHURCH AND HER RIGHTS

19. The Church is not a true and perfect society, entirely free- nor is she endowed with proper and perpetual rights of her own, conferred upon her by her Divine Founder; but it appertains to the civil power to define what are the rights of the Church, and the limits within which she may exercise those rights. -- Allocution "Singulari quadam,&quuot; Dec. 9, 1854, etc.

20. The ecclesiastical power ought not to exercise its authority without the permission and assent of the civil government. -- Allocution "Meminit unusquisque," Sept. 30, 1861.

21. The Church has not the power of defining dogmatically that the religion of the Catholic Church is the only true religion. -- Damnatio "Multiplices inter," June 10, 1851.

22. The obligation by which Catholic teachers and authors are strictly bound is confined to those things only which are proposed to universal belief as dogmas of faith by the infallible judgment of the Church. -- Letter to the Archbishop of Munich, "Tuas libenter," Dec. 21, 1863.

23. Roman pontiffs and ecumenical councils have wandered outside the limits of their powers, have usurped the rights of princes, and have even erred in defining matters of faith and morals. -- Damnatio "Multiplices inter," June 10, 1851.

24. The Church has not the power of using force, nor has she any temporal power, direct or indirect. -- Apostolic Letter "Ad Apostolicae," Aug. 22, 1851.

25. Besides the power inherent in the episcopate, other temporal power has been attributed to it by the civil authority granted either explicitly or tacitly, which on that account is revocable by the civil authority whenever it thinks fit. -- Ibid.

26. The Church has no innate and legitimate right of acquiring and possessing property. -- Allocution "Nunquam fore," Dec. 15, 1856; Encyclical "Incredibili," Sept. 7, 1863.

27. The sacred ministers of the Church and the Roman pontiff are to be absolutely excluded from every charge and dominion over temporal affairs. -- Allocution "Maxima quidem," June 9, 1862.

28. It is not lawful for bishops to publish even letters Apostolic without the permission of Government. -- Allocution "Nunquam fore," Dec. 15, 1856.

29. Favours granted by the Roman pontiff ought to be considered null, unless they have been sought for through the civil government. -- Ibid.

30. The immunity of the Church and of ecclesiastical persons derived its origin from civil law. -- Damnatio "Multiplices inter," June 10, 1851.

31. The ecclesiastical forum or tribunal for the temporal causes, whether civil or criminal, of clerics, ought by all means to be abolished, even without consulting and against the protest of the Holy See. -- Allocution "Nunquam fore," Dec. 15, 1856; Allocution "Acerbissimum," Sept. 27, 1852.

32. The personal immunity by which clerics are exonerated from military conscription and service in the army may be abolished without violation either of natural right or equity. Its abolition is called for by civil progress, especially in a society framed on the model of a liberal government. -- Letter to the Bishop of Monreale "Singularis nobisque," Sept. 29, 1864.

33. It does not appertain exclusively to the power of ecclesiastical jurisdiction by right, proper and innate, to direct the teaching of theological questions. -- Letter to the Archbishop of Munich, "Tuas libenter," Dec. 21, 1863.

34. The teaching of those who compare the Sovereign Pontiff to a prince, free and acting in the universal Church, is a doctrine which prevailed in the Middle Ages. -- Apostolic Letter "Ad Apostolicae," Aug. 22, 1851.

35. There is nothing to prevent the decree of a general council, or the act of all peoples, from transferring the supreme pontificate from the bishop and city of Rome to another bishop and another city. -- Ibid.

36. The definition of a national council does not admit of any subsequent discussion, and the civil authority car assume this principle as the basis of its acts. -- Ibid.

37. National churches, withdrawn from the authority of the Roman pontiff and altogether separated, can be established. -- Allocution "Multis gravibusque," Dec. 17, 1860.

38. The Roman pontiffs have, by their too arbitrary conduct, contributed to the division of the Church into Eastern and Western. -- Apostolic Letter "Ad Apostolicae," Aug. 22, 1851.

VI. ERRORS ABOUT CIVIL SOCIETY, CONSIDERED BOTH IN ITSELF AND IN ITS RELATION TO THE CHURCH

39. The State, as being the origin and source of all rights, is endowed with a certain right not circumscribed by any limits. -- Allocution "Maxima quidem," June 9, 1862.

40. The teaching of the Catholic Church is hostile to the well- being and interests of society. -- Encyclical "Qui pluribus," Nov. 9, 1846; Allocution "Quibus quantisque," April 20, 1849.

41. The civil government, even when in the hands of an infidel sovereign, has a right to an indirect negative power over religious affairs. It therefore possesses not only the right called that of "exsequatur," but also that of appeal, called "appellatio ab abusu." -- Apostolic Letter "Ad Apostolicae," Aug. 22, 1851

42. In the case of conflicting laws enacted by the two powers, the civil law prevails. -- Ibid.

43. The secular Dower has authority to rescind, declare and render null, solemn conventions, commonly called concordats, entered into with the Apostolic See, regarding the use of rights appertaining to ecclesiastical immunity, without the consent of the Apostolic See, and even in spite of its protest. -- Allocution "Multis gravibusque," Dec. 17, 1860; Allocution "In consistoriali," Nov. 1, 1850.

44. The civil authority may interfere in matters relating to religion, morality and spiritual government: hence, it can pass judgment on the instructions issued for the guidance of consciences, conformably with their mission, by the pastors of the Church. Further, it has the right to make enactments regarding the administration of the divine sacraments, and the dispositions necessary for receiving them. -- Allocutions "In consistoriali," Nov. 1, 1850, and "Maxima quidem," June 9, 1862.

45. The entire government of public schools in which the youth- of a Christian state is educated, except (to a certain extent) in the case of episcopal seminaries, may and ought to appertain to the civil power, and belong to it so far that no other authority whatsoever shall be recognized as having any right to interfere in the discipline of the schools, the arrangement of the studies, the conferring of degrees, in the choice or approval of the teachers. -- Allocutions "Quibus luctuosissimmis," Sept. 5, 1851, and "In consistoriali," Nov. 1, 1850.

46. Moreover, even in ecclesiastical seminaries, the method of studies to be adopted is subject to the civil authority. -- Allocution "Nunquam fore," Dec. 15, 1856.

47. The best theory of civil society requires that popular schools open to children of every class of the people, and, generally, all public institutes intended for instruction in letters and philosophical sciences and for carrying on the education of youth, should be freed from all ecclesiastical authority, control and interference, and should be fully subjected to the civil and political power at the pleasure of the rulers, and according to the standard of the prevalent opinions of the age. -- Epistle to the Archbishop of Freiburg, "Cum non sine," July 14, 1864.

48. Catholics may approve of the system of educating youth unconnected with Catholic faith and the power of the Church, and which regards the knowledge of merely natural things, and only, or at least primarily, the ends of earthly social life. -- Ibid.

49. The civil power may prevent the prelates of the Church and the faithful from communicating freely and mutually with the Roman pontiff. -- Allocution "Maxima quidem," June 9, 1862.

50. Lay authority possesses of itself the right of presenting bishops, and may require of them to undertake the administration of the diocese before they receive canonical institution, and the Letters Apostolic from the Holy See. -- Allocution "Nunquam fore," Dec. 15, 1856.

51. And, further, the lay government has the right of deposing bishops from their pastoral functions, and is not bound to obey the Roman pontiff in those things which relate to the institution of bishoprics and the appointment of bishops. -- Allocution "Acerbissimum," Sept. 27, 1852, Damnatio "Multiplices inter," June 10, 1851.

52. Government can, by its own right, alter the age prescribed by the Church for the religious profession of women and men; and may require of all religious orders to admit no person to take solemn vows without its permission. -- Allocution "Nunquam fore," Dec. 15, 1856.

53. The laws enacted for the protection of religious orders and regarding their rights and duties ought to be abolished; nay, more, civil Government may lend its assistance to all who desire to renounce the obligation which they have undertaken of a religious life, and to break their vows. Government may also suppress the said religious orders, as likewise collegiate churches and simple benefices, even those of advowson and subject their property and revenues to the administration and pleasure of the civil power. -- Allocutions "Acerbissimum," Sept. 27, 1852; "Probe memineritis," Jan. 22, 1855; "Cum saepe," July 26, 1855.

54. Kings and princes are not only exempt from the jurisdiction of the Church, but are superior to the Church in deciding questions of jurisdiction. -- Damnatio "Multiplices inter," June 10, 1851.

55. The Church ought to be separated from the .State, and the State from the Church. -- Allocution "Acerbissimum," Sept. 27, 1852.

VII. ERRORS CONCERNING NATURAL AND CHRISTIAN ETHICS

56. Moral laws do not stand in need of the divine sanction, and it is not at all necessary that human laws should be made conformable to the laws of nature and receive their power of binding from God. -- Allocution "Maxima quidem," June 9, 1862.

57. The science of philosophical things and morals and also civil laws may and ought to keep aloof from divine and ecclesiastical authority. -- Ibid.

58. No other forces are to be recognized except those which reside in matter, and all the rectitude and excellence of morality ought to be placed in the accumulation and increase of riches by every possible means, and the gratification of pleasure. -- Ibid.; Encyclical "Quanto conficiamur," Aug. 10, 1863.

59. Right consists in the material fact. All human duties are an empty word, and all human facts have the force of right. -- Allocution "Maxima quidem," June 9, 1862.

60. Authority is nothing else but numbers and the sum total of material forces. -- Ibid.

61. The injustice of an act when successful inflicts no injury on the sanctity of right. -- Allocution "Jamdudum cernimus," March 18, 1861.

62. The principle of non-intervention, as it is called, ought to be proclaimed and observed. -- Allocution "Novos et ante," Sept. 28, 1860.

63. It is lawful to refuse obedience to legitimate princes, and even to rebel against them. -- Encyclical "Qui pluribus," Nov. 9, 1864; Allocution "Quibusque vestrum," Oct. 4, 1847; "Noscitis et Nobiscum," Dec. 8, 1849; Apostolic Letter "Cum Catholica."

64. The violation of any solemn oath, as well as any wicked and flagitious action repugnant to the eternal law, is not only not blamable but is altogether lawful and worthy of the highest praise when done through love of country. -- Allocution "Quibus quantisque," April 20, 1849.

VIII. ERRORS CONCERNING CHRISTIAN MARRIAGE

65. The doctrine that Christ has raised marriage to the dignity of a sacrament cannot be at all tolerated. -- Apostolic Letter "Ad Apostolicae," Aug. 22, 1851.

66. The Sacrament of Marriage is only a something accessory to the contract and separate from it, and the sacrament itself consists in the nuptial benediction alone. -- Ibid.

67. By the law of nature, the marriage tie is not indissoluble, and in many cases divorce properly so called may be decreed by the civil authority. -- Ibid.; Allocution "Acerbissimum," Sept. 27, 1852.

68. The Church has not the power of establishing diriment impediments of marriage, but such a power belongs to the civil authority by which existing impediments are to be removed. -- Damnatio "Multiplices inter," June 10, 1851.

69. In the dark ages the Church began to establish diriment impediments, not by her own right, but by using a power borrowed from the State. -- Apostolic Letter "Ad Apostolicae," Aug. 22, 1851.

70. The canons of the Council of Trent, which anathematize those who dare to deny to the Church the right of establishing diriment impediments, either are not dogmatic or must be understood as referring to such borrowed power. -- Ibid.

71. The form of solemnizing marriage prescribed by the Council of Trent, under pain of nullity, does not bind in cases where the civil law lays down another form, and declares that when this new form is used the marriage shall be valid.

72. Boniface VIII was the first who declared that the vow of chastity taken at ordination renders marriage void. -- Ibid.

73. In force of a merely civil contract there may exist between Christians a real marriage, and it is false to say either that the marriage contract between Christians is always a sacrament, or that there is no contract if the sacrament be excluded. -- Ibid.; Letter to the King of Sardinia, Sept. 9, 1852; Allocutions "Acerbissimum," Sept. 27, 1852, "Multis gravibusque," Dec. 17, 1860.

74. Matrimonial causes and espousals belong by their nature to civil tribunals. -- Encyclical "Qui pluribus," Nov. 9 1846; Damnatio "Multiplices inter," June 10, 1851, "Ad Apostolicae," Aug. 22, 1851; Allocution "Acerbissimum," Sept. 27, 1852.

IX. ERRORS REGARDING THE CIVIL POWER OF THE SOVEREIGN PONTIFF

75. The children of the Christian and Catholic Church are divided amongst themselves about the compatibility of the temporal with the spiritual power. -- "Ad Apostolicae," Aug. 22, 1851.

76. The abolition of the temporal power of which the Apostolic See is possessed would contribute in the greatest degree to the liberty and prosperity of the Church. -- Allocutions "Quibus quantisque," April 20, 1849, "Si semper antea," May 20, 1850.

X. ERRORS HAVING REFERENCE TO MODERN LIBERALISM

77. In the present day it is no longer expedient that the Catholic religion should be held as the only religion of the State, to the exclusion of all other forms of worship. -- Allocution "Nemo vestrum," July 26, 1855.

78. Hence it has been wisely decided by law, in some Catholic countries, that persons coming to reside therein shall enjoy the public exercise of their own peculiar worship. -- Allocution "Acerbissimum," Sept. 27, 1852.

79. Moreover, it is false that the civil liberty of every form of worship, and the full power, given to all, of overtly and publicly manifesting any opinions whatsoever and thoughts, conduce more easily to corrupt the morals and minds of the people, and to propagate the pest of indifferentism. -- Allocution "Nunquam fore," Dec. 15, 1856.

80. The Roman Pontiff can, and ought to, reconcile himself, and come to terms with progress, liberalism and modern civilization.- -Allocution "Jamdudum cernimus," March 18, 1861.

The faith teaches us and human reason demonstrates that a double order of things exists, and that we must therefore distinguish between the two earthly powers, the one of natural origin which provides for secular affairs and the tranquillity of human society, the other of supernatural origin, which presides over the City of God, that is to say the Church of Christ, which has been divinely instituted for the sake of souls and of eternal salvation.... The duties of this twofold power are most wisely ordered in such a way that to God is given what is God's (Matt. 22:21), and because of God to Caesar what is Caesar's, who is great because he is smaller than heaven. Certainly the Church has never disobeyed this divine command, the Church which always and everywhere instructs the faithful to show the respect which they should inviolably have for the supreme authority and its secular rights....

. . . Venerable Brethren, you see clearly enough how sad and full of perils is the condition of Catholics in the regions of Europe which We have mentioned. Nor are things any better or circumstances calmer in America, where some regions are so hostile to Catholics that their governments seem to deny by their actions the Catholic faith they claim to profess. In fact, there, for the last few years, a ferocious war on the Church, its institutions and the rights of the Apostolic See has been raging.... Venerable Brothers, it is surprising that in our time such a great war is being waged against the Catholic Church. But anyone who knows the nature, desires and intentions of the sects, whether they be called masonic or bear another name, and compares them with the nature the systems and the vastness of the obstacles by which the Church has been assailed almost everywhere, cannot doubt that the present misfortune must mainly be imputed to the frauds and machinations of these sects. It is from them that the synagogue of Satan, which gathers its troops against the Church of Christ, takes its strength. In the past Our predecessors, vigilant even from the beginning in Israel, had already denounced them to the kings and the nations, and had condemned them time and time again, and even We have not failed in this duty. If those who would have been able to avert such a deadly scourge had only had more faith in the supreme Pastors of the Church! But this scourge, winding through sinuous caverns, . . . deceiving many with astute frauds, finally has arrived at the point where it comes forth impetuously from its hiding places and triumphs as a powerful master. Since the throng of its propagandists has grown enormously, these wicked groups think that they have already become masters of the world and that they have almost reached their pre-established goal. Having sometimes obtained what they desired, and that is power, in several countries, they boldly turn the help of powers and authorities which they have secured to trying to submit the Church of God to the most cruel servitude, to undermine the foundations on which it rests, to contaminate its splendid qualities; and, moreover, to strike it with frequent blows, to shake it, to overthrow it, and, if possible, to make it disappear completely from the earth. Things being thus, Venerable Brothers, make every effort to defend the faithful which are entrusted to you against the insidious contagion of these sects and to save from perdition those who unfortunately have inscribed themselves in such sects. Make known and attack those who, whether suffering from, or planning, deception, are not afraid to affirm that these shady congregations aim only at the profit of society, at progress and mutual benefit. Explain to them often and impress deeply on their souls the Papal constitutions on this subject and teach, them that the masonic associations are anathematized by them not only in Europe but also in America and wherever they may be in the whole world.

To the Archbishops and Bishops of Prussia concerning the situation of the Catholic Church faced with persecution by that Government....

But although they (the bishops resisting persecution) should be praised rather than pitied, the scorn of episcopal dignity, the violation of the liberty and the rights of the Church, the ill treatment which does not only oppress those dioceses, but also the others of the Kingdom of Prussia, demand that We, owing to the Apostolic office with which God has entrusted us in spite of Our insufficient merit, protest against laws which have produced such great evils and make one fear even greater ones; and as far as we are able to do so with the sacred authority of divine law, We vindicate for the Church the freedom which has been trodden underfoot with sacrilegious violence. That is why by this letter we intend to do Our duty by announcing openly to all those whom this matter concerns and to the whole Catholic world, that these laws are null and void because they are absolutely contrary to the divine constitution of the Church. In fact, with respect to matters which concern the holy ministry, Our Lord did not put the mighty of this century in charge, but Saint Peter, whom he entrusted not only with feeding his sheep, but also the goats; therefore no power in the world, however great it may be, can deprive of the pastoral office those whom the Holy Ghost has made Bishops in order to feed the Church of God.