Tuesday, November 14, 2023

Magnum

Magnum (pronounced mag-nuhm)

(1) A large wine bottle having a capacity of two ordinary bottles or 1.5 liters (1.6 quarts).

(2) In ballistics, a magnum cartridge or firearm (a loaded with a larger charge than other cartridges of the same calibre).

(3) A firearm using such a cartridge.

(4) Used generally, unusually great in power or size:

1788:  From the Latin magnum (“great, large, big" (of size), "great, considerable" (of value), "strong, powerful" (of force); of persons, "elder, aged"), neuter of magnus (large), from a suffixed form of the primitive Indo-European root meg- (great).  The original use in English was to describe the large wine-bottle, then usually containing two quarts.  As the name of a powerful type of handgun, it was first registered in 1935 by the US company, Smith & Wesson of Springfield, Massachusetts.  Outside of ballistics, the most common use is now probably “magnum opus" (masterpiece, a person's greatest work, literally "great work", applied, in literature, music, art and (sometime a little liberally) popular culture.  Magnum is a noun; the noun plural is magnums or magna.

The magnum’s place in the hierarchy of Champagne bottles.

Magnum ammunition

Lindsay Lohan in habit with Smith & Wesson .500 Magnum, Machete (2010).

Released in September 2010 at the Venice Film Festival and distributed internationally by Sony Pictures, Machete would probably be more highly regarded if the full-length feature had lived up to the promise created by the artfully-edited trailer.  Probably about twenty minutes too long, the critical consensus suggests Machete was a violent, shallow, repetitive and probably unnecessary addition to whatever was the sub-genre of exploitation it inhabited.  That said, the production values were thought high enough for those who like this sort of thing to be able to look forward to it as one of the more enjoyable movies of the summer of 2010.

Smith & Wesson .357 Magnum.

A magnum cartridge is one with a larger case size than the standard cartridge of the same calibre and case shoulder shape.  The now generic term is derived from Smith & Wesson’s Original .357 S&W Magnum, introduced in 1934; magnum ammunition containing either or both additional propellant or a heavier projectile but the term is a bit of an anomaly in the business of ballistics.  Although in the terminology of firearms, most jargon is explicitly defined, “magnum ammunition” has no precise codified set of standards, instead being just an indication of the possession of more powerful characteristics than other loads of the same calibre and shape.  One revolver which has found a niche is the .22 Magnum.  Although in the public imagination it lurks behind the bigger calibre loads (.357, .44, .50), it's a practical device which can use the .22 LR (Long Rifle) shell and manufacturers offer them with a cylinder capacity of 10 or 12, more than many semi-automatics.  Retailers recommend them for non-expert shooters because with a minimal recoil when firing, they're easy to handle and the rule is it’s better to have a .22 LR that hits its target than a .44 Magnum that misses it. 

Smith & Wesson .500 Magnum.

Smith & Wesson’s original .357 Magnum was introduced in 1934 in response to the growing availability of bullet-proofing technology in both automobiles and the ballistics vests used for personal protection.  It was an attempt to provide greater penetrative power without the need to increase the bore with the consequential increase in the size and weight of weapons.  Predictably though, the arms race had begun, and in the decades which followed, magnum loads would become available for a wide range of calibres, hand guns and long arms as well as shotguns, the classic .44 Magnum, later made famous in popular culture, released in 1954.  It didn’t stop there, increasing demand for the .44 convincing Smith & Wesson to develop the .500 Magnum, currently the most powerful handgun load generally available and one marketed, in addition to its other attractions, to those who might find it more convenient than a rifle for hunting big game.  The size, weight and recoil however mean it’s not suitable for all and in the US, .500 is anyway the legal limit for handgun loads.  In US law, it’s a rare restriction.

.460 Weatherby Magnum.

For that reason, even Smith and Wesson do recommend that unless one plans to hunt elephant at close range or expect to confront a charging wild boar, loads like the .357 Magnum are better for what most people do most of the time.  The same caution applies to the Magnum loads for rifles, the .375 Magnum often nominated by experts as the perfect compromise for all but the most extreme applications.  Indeed, it was loads like the .375 Magnum which eliminated most of the need for the famous old-style “elephant guns” like Holland & Holland’s .600 Nitro and the .458 and .460 Magnum cartridges of the 1950s were necessitated only by regulations governing big-game hunting in Africa mandating a load above .400.  Despite that, demand for the heavy calibres remains strong, Holland and Holland, after introducing a canon-like .700 Nitro found demand so unexpectedly strong that they resumed production of the long retired .600.  While it seems unlikely heavier loads will be thought practical, that may not matter, there being some evidence many of the .700 Nitros are sold to collectors, never to be fired.

That said, Austria’s Pfeifer firearms created supply to meet what demand there may be.  The Pfeifer .600 Nitro Express Zeliska single-action revolver weighs over 13 lb (4.85 kg) and is  22 inches (.56 m) in length, the cylinder section alone weighing 4.5 lb (17 kg).  Although generating a muzzle energy of 7,591 foot pounds (33.7 kn), paradoxically, the weight of the gun actually limits the recoil, making controlled shooting possible although, practice is essential.  With a cylinder capacity of either five .600 Nitro or .458 Winchester Magnum rounds, it's able to fire a 900 grain, .600 some 2000 feet (600+ m).  At release, Zeliska listed the revolver at US$17,316 and because each .600 Nitro Express round costs about US$45, it’s an expensive hobby.

The Magnum Concilium

Dating from Norman times, the Magnum Concilium (Great Council) was an English assembly eventually composed of senior ecclesiastics, noblemen and representatives of the counties of England and Wales (and later of the boroughs too) which was from time-to-time convened to discuss matter of state with the king and his advisors (sitting as the Curia Regis (King's Court; a kind of predecessor to the Privy Council and later the cabinet).  The Magnum Concilium evolved into the Concilium Regis in Parliamento (the parliament of England), the first generally thought to be the so-called "Model Parliament" of 1295, which included archbishops, bishops, abbots, earls, barons, and representatives of the shires and boroughs.  The evolution wasn’t linear, power in the land a constant struggle between king and parliament, the authority of both fluctuating as the politics of the day effed and flowed.  Nor was the parliament a united force, shrewd kings knowing how to exploit divisions between the parliamentary factions but by the reign of Edward II (1284-1327; as Edward of Caernarfon, King of England 1307-1327), the nobility was ascendant, the Crown compliant and the rest essentially irrelevant.

Execution Of Charles I, 1649 (circa 1850) by an unknown artist.

Under Edward III (1312–1377; as Edward of Windsor, King of England 1327-1377), the modern bicameral structure (a House of Commons & a House of Lords), became clear and the authority of Parliament grew although the Lords remained by far the most powerful because that was where the economic resources were concentrated.  That reality was reflected by the practice, under the Plantagenet kings, of the summoning of the Magnum Concilium being something exclusively ecclesiastical & aristocratic, the representatives of the commons rarely in attendance.  After Henry VII (1457–1509; King of England 1485-1509) convened the Magnum Concilium on several occasions in the late 1400s, for various reasons, its participation in the governance of England went into abeyance until, in 1640, Charles I was advised to summon the Magnum Concilium after he’d dissolved the Short Parliament in order to raise money because his misrule and wars of adventure had bankrupted the state.  The king got his money but his private army was soon at war with the parliamentary forces of both Scotland and England and those wars did not for him go well.  Before the decade was over, he would be beheaded.  The Magnum Concilium has not since met but experts in English constitutional law have confirmed it still exists and can, at any time, be summoned by the Crown.

Chrysler’s 440 Magnum Six-Pack

383 Magnum V8 with cross-ram induction in in 1960 Dodge Dart Phoenix D-500.

Chrysler’s family of big-block wedge V8s lasted from 1958 until 1978 but, although the label is often commonly applied, not all were designated “Magnum”.  The first Magnum was a high-performance version of the B-series 383 cubic inch (6.3 litre) V8 (which differs from the later RB 383), the highlight being the option of a (long) cross-ram inlet manifold with two four-barrel carburetors.  It was only Dodge which used the Magnum label; the equivalent power-plant in a Plymouth was called a Commando (there were adjectives sometimes added) and in a Chrysler, a TNT.

1970 Dodge 440 Magnum Six-Pack.

Introduced in 1969, the highest evolution of the RB Magnum were the 440 cubic inch (7.2 litre) versions built with three Holley 2300 series two-barrel carburetors instead of the more commonly seen single carburetor induction (which were on the 440 almost exclusively in four-barrel form).  The early versions used an Edelbrock manifold cast in aluminum but supply difficulties forced Chrysler also to cast their own in cast-iron to meet demand.  Although obviously a high-performance variation, marketed by Dodge as the 440 Magnum Six-Pack, the engine was engineered to use only the centre 250 cubic feet per minute (7 m3) carburetor under normal throttle loads, the outer two 370 cfm (10.4 m3) units used only if summoned (something like the "demand" superchargers on Weimar-era Mercedes-Benz, the kompressor activated only when the throttle was pushed wide-open, high in the rev range).  If one could resist the temptation of the sudden onrush of power, the Magnum Six-Pack could be quite economical by the admittedly slight standards of the time, simply because, when driven with restraint, it was percolating along with only the one two-barrel carburetor active.

440 Magnum Six-Pack in 1970 Dodge Challenger.

Internally, the Six-Pack Magnums differed from the single carburetor engines in the use of stiffer valve springs borrowed from the 426 Street Hemi, stronger rocker arms (strengthened connecting rods were added in 1970), molybdenum-filled piston rings and flash chromed valves (which is why simply adding the six-pack induction system to a standard 440 can end badly).  Better to cope with the additional stresses imposed by those high-tension springs, the camshaft lobes and lifter faces were blueprinted to equalise the loads, the lifters rotating to distribute wear equally across the surfaces subject to friction.  With its compression ratio upped from 10.1:1 to 10.5:1, upon release, the Magnum Six-Pack was rated at 390 bhp (290 kw), dropping slightly to 385 (287) when some minor anti-emission adjustments were made in 1971.  At around half the price of Chrysler’s much-vaunted Street-Hemi adaptation of the race engine, the Magnum Six-Pack was a bargain, at least matching the Hemi in most aspects of performance until speeds above 120 mph (190 km/h) were attained, along with a longer manufacturer’s warranty and lower insurance costs, at least for some.  It was good while it lasted but in the US, 1971 was the swansong for both the Magnum Six-Pack and the Street-Hemi, emission regulations and an astonishing increase in the cost of insuring the things crushing demand.

1971 Jensen FF Series III, one of 15 made from a total production (1966-1971) of 320.

Across the Atlantic however, the Six-Pack Magnum did enjoy a brief afterlife after being driven extinct in the US.  Jensen, in the throes of phasing out their acclaimed but unprofitable all-wheel-drive FF, were looking for a flagship which could be created quickly and cheaply, ruling out the mooted convertible which wouldn’t appear for some years.  With their planned new F-Type unlikely to be on sale before 1973, the need was for something which demanded neither much development time nor an onerous budget.  As it was, circumstances contrived to ensure the F-Type was stillborn after a single prototype was built.

The much admired louvers on 1972 Jensen SP.  So much did the look appeal a louvered bonnet (hood) of a slightly different design was later made available on the standard Interceptor.

Jensen had for years been building their Interceptor & FF models with the Chrysler RB engines and had even flirted with the idea of doing a run with the Street Hemi, a project aborted when the costs of adaptation became apparent.  In late 1970, Jensen’s need for something was communicated to Chrysler which, by happy coincidence, had a batch of Magnum Six-Pack engines which had been gathering dust in a Canadian warehouse since being effectively orphaned by the new US emission control legislation.  Within days, agreement was reached, Jensen taking delivery of the first tranche of the batch which, although unable to be sold in the US, were legal just about everywhere else.  The mechanical specification settled, discussions then turned to other features which could be included to enhance the car’s status as a premium product.  Because it was the 1970s (and there's really no other excuse), without much discussion, it was agreed to glue on a vinyl roof; that many others did the same thing is no defense but it wasn't obligatory; of the 232 SPs, there were 185 with a black vinyl roof, 15 in tan, two in white while three subversives ordered the "Duotone" paint option with the roof painted a contrasting color.  More defensible was the inclusion of a high-quality and very expensive Learjet eight-track cartridge stereo system and, to provide some continuity with the FF, it was decided to use that model’s blue-themed badges rather than the red used on the Interceptor.  Also, interestingly, it was during these initial discussions that a fully louvered bonnet (hood) would be included in the specification but there’s no indication there was any concern about additional engine-bay heat, the louvers apparently just a styling device to evoke memories of earlier eras when they were common on high-performance machinery.  There was little debate about the name; several people had suggested SP was the obvious choice.  In December 1970, the first prototype SP was built although the intricacies of the triple carburetor engine weren’t entirely new to Jensen’s engineers, having a few months earlier fitted one to an Interceptor.  Assessment of the prototype proved the adaptation was as straight-forward as expected, the minor issue of the additional clearance demanded by the big air-filter effected by a quick fix to the filter housing.

1971 Jensen SP at the Geneva Motor Show, March 1972.  Just twelve were built in left-hand drive configuration because the SP engine couldn't meet the new US emission standards, thereby precluding sales in the market most receptive to thirsty machines.

Scheduled for release in the northern autumn of 1971, Jensen’s original plan had been to announce the SP as part of their new range including the Mark III versions of both the Interceptor and FF but the realities of the future made apparent the mixed-messaging was a bad idea.  The SP was intended to be the new top-of-the line model so announcing it with an updated version of the doomed yet still more expensive FF made little sense, the Mark III FF created only as a way to ensure the last fifteen FF body-shells (the all-wheel drive configuration necessitated a longer wheelbase) could be utilised.  Almost all FF marketing was thus terminated and the emphasis switched to the new two-model range with the SP sitting atop which meant the Mark III FF, which would become one of the Jensens most prized by collectors, went at the time almost unnoticed.

1972 Monteverdi 375/4.

Beginning its tour of the motor show circuit, the new flagship was greeted with subdued interest by the motoring press which viewed the SP as the hot rod Interceptor it was and which, while entertaining in a occasionally brutish (and rather un-Jensen like) sort of way, was not as intriguing as the soon-to-be lamented FF, the prowess of which had so astonished all who drove it, exploring for the first time the revolutionary possibilities of anti-lock braking and all-wheel-drive.  Nevertheless, the performance did impress, a top-speed of 143 mph (230 km/h) being reported although it was noted the even bigger and heavier 375/4 limousine made by boutique Swiss manufacturer Monteverdi had been clocked just a little faster and it used the 440 with only a single four barrel carburetor.  Still it was fast enough and nobody complained the SP lacked pace.

Jensen SP press release, 5 October 1971.

What did elicit complaint was the manner in which that speed sometimes arrived.  The tremendous delivery of power at full-throttle was praised but the lack of predictable response lower in the rev-range attracted criticism, the additional carburetors kicking in sometimes unexpectedly and not always when the car was heading in a straight line.  Issues with hot-starting were also apparent and even the otherwise much admired multi-louvered bonnet was found not the be without fault, the slats apparently changing either the properties of the metal or the reaction of the shape to the fluid dynamics of air-flow; at speed, the bonnet would “slightly shiver, almost as though improperly fastened” and testers, used to the cocoon-like stability of the Interceptor and FF, found it disconcerting.  While none of the reviews were damning, nor were they much more than polite.  Surprisingly, the only mention testers made of the standard air-conditioning (A/C) was that it worked well but it deserved a longer note because Jensen was the only factory which fitted A/C to a triple-carburetor 440, Plymouth & Dodge in the US never offering the option.  Monteverdi enjoys a similar distinction, it's Hai (two of which were built in 1971 & 1973) the only vehicle powered by Chrysler's 426 cubic inch (7.0 litre) Street Hemi V8 to have factory fitted A/C.

1972 Jensen SP engine bay.

Worse was to come as customers started reporting problems, the first being the issue of under-bonnet heat.  Although a big machine by European standards, the engine bay of the Jensen was smaller than anything to which it’d been fitted in the US and, even with the louvers helping to ventilate the space, it got very hot in there and this quickly affected the carburetors which had never before been exposed to such extremes; parts warping as the metal heated and then cooled, causing air-gaps to emerge, making accurate tuning, vital with multiple-carburetion, impossible.  The factory was soon receiving reports of engines which refused to idle and, due to the inherent nature of the Holly 2300 carburetor design, engines would run too rich after a week or so of nothing more than normal driving.

Chocolate fiend Lindsay Lohan with Magnum (ice cream) backdrop.

For a small company like Jensen, it was a major setback.  The company had built the Interceptor's reputation on reliability and ease of ownership essentially by piggy-backing on the back of the bullet proof Chrysler V8s and TorqueFlite transmissions it had begun using in the Interceptor's predecessor, the CV8.  The approach, adopted by many in this era, appealed to buyers not sufficiently seduced by the bespoke charm and mechanical intricacies of the continental competition to wish to deal with the cost and inconvenience of the more demanding maintenance schedules (and expensive parts catalogue) listed by Ferrari, Lamborghini & Maserati.  Like the MGA Twin-Cam (and for that matter the later Jensen-Healey), the SP was a classic case of insufficient product development and testing, examples of which littered the post-war UK industry.  Perhaps there was complacency because (1) multiple carburetors were nothing new to British manufacturers and (2) the Six-Pack Magnum had a good record of reliability in the US.  However, three Hollys on a big-block Chrysler turned out to behave differently to three big SUs on a Jaguar XK-six.                  

1970 Dodge Super Bee 440 Magnum Six-Pack with typical girlfriend of typical buyer.

The occasional quirk of the Magnum Six-Pack was not unknown in the US but there the nature of the thing was well-understood; it was a hot-rod engine bought by those who wanted such things, most owners young, male, mechanically adept and often anxious to tinker under the hood (bonnet).  The Jensen buyer was a wholly different demographic, mostly older, affluent men who either had rarely seen under a bonnet or hadn’t looked for many years and their expectations of a car which was twice as expensive as Jaguar’s V12 E-Type were very different to those youthful Californian baby boomers had of their hotted-up taxi cabs.  Used to the effortless, if thirsty, behavior of the Interceptor, some found their SPs, the high-performance of which most could rarely explore, were behaving like brand new, very expensive old clunkers.

Jensen FF with typical mistress of typical buyer.  This is not a period photograph but is English model Harriadnie Beau Phipps (b 1993) in a 2014 photo-shoot for Oxfordshire-based UK operation Bavarez which specialized in restoring & modifying Interceptors. 

Weeks of testing and experiments with all sorts of adjustments proved pointless.  In Jensen’s workshops it was always possible to produce a perfectly running SP but, after sometimes as little as a week in the hands of owner, it would be back, displaying the same symptoms and in the end, Jensen admitted defeat and offered the only solution guaranteed to work: remove the triple induction system and replace it with the Interceptor’s faithful Carter Thermoquad four barrel carburetor.  That alleviated all the drivability issues but did mean that having paid their £6,976.87, a premium of a thousand-odd pounds over the anyway expensive Interceptor, the emasculated SP became an Interceptor with a vinyl roof, an eight-track cartridge player and a vibrating bonnet.  The factory’s records suggest between a quarter and a third of buyers opted for the Theromquad fix and some refunds were paid to the especially unhappy.

Last gasp: 1974 Jensen Interceptor convertible.

Although Jensen had known, because the Magnum Six-Pack was out of production, the SP was not going to have a long life, it had been hoped it would fulfil its role until the new F-Type was expected to be released in 1973.  However, having built 208 SPs, Jensen didn’t take up their option on what was still in Chrysler’s Canadian remainder bin and, once the stock already delivered was exhausted, the SP was allowed quietly to die.  Between September 1971 and July 1973, 231 Jensen SPs were completed with one final example built in October, a special order from someone who really wanted one.   

1972 Jensen-Healey publicity shot.

It was the start of a run of bad luck that would doom also the Interceptor and the entire company: (1) Development issues would beset the F-Type which would never see the light of day, (2) the Jensen-Healey (1972-1976) sports car which had seemed so promising turned into an expensive flop and (3) the first oil shock in 1973 rendered the Interceptor and many of its ilk suddenly big, thirsty dinosaurs and not even the release in 1974 of a much-admired convertible version could rescue things.  Bankruptcy loomed and by 1976 the end came.  However, flawed but charismatic English cars, decades on, sometimes enjoy second acts and SPs are now much prized with a small industry devoted to restoring them to their six-barreled glory, modern materials and techniques of insulation & cooling now able to transform them into something as well-behaved as any Interceptor.

Monday, November 13, 2023

Somnambulism

Somnambulism (pronounced som-nam-byuh-liz-uhm or suhm- nam-byuh-liz-uhm)

Sleepwalking; a condition characterized by walking while asleep or in a hypnotic trance

1786: A Modern English borrowing, via the French somnambulisme from the New Latin somnambulismus (sleepwalker), the construct of the original being somn(us) (sleep) + ambul(āre) (to walk) + -ismus (equivalent to the English –ism).  In English, the construct became somnus + ambulo + -ism.  Somnus came from the Proto-Italic swepnos, from the primitive Indo-European swépnos, from the root swep- (to sleep); the form spread east too, including the Lithuanian sãpnas.  Ambulo is from ambi- + alō (to wander”), from the primitive Indo-European hzel- (to wander) and was cognate with the Ancient Greek λη (álē) (wandering) & λύω (alúō) (to wander in mind, to roam).  The suffix –ism is ultimately from either the Ancient Greek -ισμός (-ismós), a suffix that forms abstract nouns of action, state, condition, doctrine; from stem of verbs in -ίζειν (-ízein) (from which whence English gained -ize), or from the related suffix from Ancient Greek -ισμα (-isma), which more specifically expressed a finished act or thing done.  Somnambulist is a noun, somnambulation a verb and somnambulistic an adjective; in the technical jargon of clinicians, there’s the mysterious semisomnambulistic, the implication presumably that somnambulism (at least when not raised in court as a defense) may be a spectrum condition.  Somnambulism, somnambulator, somnambulation, somnambulance & somnambulist are nouns, somnambulate & somnambulating are verb, somnambular, somnambulic & somnambulistic are adjectives and somnambulistically is an adverb; the most common noun plural is somnambulists.

Sleepwalking scene, Lady Macbeth (1829), by Johann Heinrich Ramberg (1763–1840).

As it was in science, philosophy and art, the Enlightenment proved productive in words, creations needed to describe newly discovered things and novel ideas.  The noun somnambulism came into use originally during the excitement over "animal magnetism"; it won out over noctambulation which endured not long.  A flurry of linguistic action ensued in the early nineteenth century including somnambule (1837), somnambulator (1803), somnambulary (1827) & somnambular (1820).  When the theory of animal magnetism (the doctrine that one person can exercise influence over the will and nervous system of another and produce certain phenomena by virtue of a supposed emanation called animal magnetism) was published in 1778, it created great interest.  Called mesmerism (from the French mesmérisme and named for Franz Anton Mesmer (1734-1815), an Austrian physician who developed a theory of animal magnetism and a mysterious body fluid which allows one person to hypnotize another), the still used word is synonymous with hypnotism or artificial somnambulism.  Another similar word for the same effect was braidism, named after English physician James Braid (1795-1860) and an ancient term for "hypnotic suggestion" was "mesmeric promise".

Somnambulism is classified among the parasomnias, sleep-wake disorders characterized by undesirable motor, verbal, or experiential phenomena occurring in association with sleep, specific stages of sleep, or sleep-awake transition phases.  In the fifth edition of the American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5 (2013)), somnambulism is noted as a condition rather than a mental illness with most attention given to the protocols to be followed when awakening sleepwalkers.

Lindsay Lohan and her lawyer in court, Los Angeles, December 2011.

The other profession to take interest in somnambulism is the criminal bar.  At common law, sleepwalking can in some circumstances be a complete defense to any charge including murder.  That’s because the law (generally) will convict in criminal matters only if intent can be proved and that requires a “guilty mind”.  The legal Latin is mēns rea (literally “guilty mind”), from the English common law precept actus non facit reum nisi mens rea sit (the act does not make a person guilty unless the mind is also guilty).  It’s rarely successful but if it can be proved a defendant was, at the time of the act, “a sane automaton” (ie in effect sleepwalking and thus unaware of their actions), it’s an absolute defense.  Lawyers like it because sane automatism is a defense even against crimes of strict liability like dangerous driving, where no intent is necessary.  If the defense succeeds, the defendant walks free, unlike a finding of insanity (ie the notion of the insane automaton) where even if not found guilty, they're anyway locked-up.

Sunday, November 12, 2023

Efficacy

Efficacy (pronounced ef-i-kuh-see)

(1) A capacity for producing a desired result or effect; effectiveness; an ability to produce a desired effect under ideal testing conditions.

(2) The quality of being successful in producing an intended result; effectiveness; a measure of the degree of ability to produce a desired effect.

1520-1530: From the Old French efficace (quality of being effectual, producing the desired effect), from the Late Latin efficācia (efficacy), from efficāx (powerful, effectual, efficient), genitive efficacis (powerful, effective), from stem of efficere (work out, accomplish).  In eleventh century English, in much the same sense was efficace from the Old French eficace from the same Latin root efficācia; there was also the early fifteenth century efficacite from the Latin efficacitatem.  The sixteenth century adjective efficacious (certain to have the desired effect) was often used of medicines (presumably a favorite of apothecaries), the construct being the Latin efficaci-, stem of efficax from the stem of efficere (work out, accomplish)  + -ous.  The –ous suffix was from the Middle English -ous, from the Old French –ous & -eux, from the Latin -ōsus (full, full of); a doublet of -ose in an unstressed position.  It was used to form adjectives from nouns, to denote possession or presence of a quality in any degree, commonly in abundance.  In chemistry, it has a specific technical application, used in the nomenclature to name chemical compounds in which a specified chemical element has a lower oxidation number than in the equivalent compound whose name ends in the suffix -ic.  For example, sulphuric acid (H2SO4) has more oxygen atoms per molecule than sulphurous acid (H2SO3).  The noun inefficacy (want of force or virtue to produce the desired effect) dates from the 1610s, from the Late Latin inefficacia, from inefficacem (nominative inefficax), the construct being in- (not, opposite of) + efficax.

The most familiar related form in modern use is efficacious but in general use this is often used in a more nuanced way than the pass/fail dichotomy of "efficacy" familiar in medical trials.  In general use, efficacious is a "spectrum word" which describes degrees of the ameliorative effects of treatments although while the comparative is "more efficacious", a more common form is "quite efficacious"; the superlative "most efficacious" appears to be popular among the small subset of the population who use efficacious at all.  Efficacy, efficacity & efficaciousness are nouns, effectuate is a verb, effectual & efficacious are adjectives and efficaciously is an adverb; the noun plural is efficacies.

Clinical trials in the pharmaceutical industry

In the development of vaccines (and medicinal drugs in general), efficacy trials (sometimes called phase III or explanatory trials) determine the percentage reduction of disease in a vaccinated group of people compared to an unvaccinated group, under the most favorable conditions, which is with the subjects housed in a hospital equipped to handle intensive care patients.  Conducted on human subjects if tests on animals proved satisfactory, it’s a purely clinical exercise, practiced since 1915 and can be done as a double-blind, randomized study if no safety concerns exist.  One potentially distorting aspect of both efficacy and (particularly) safety trials is a historic bias towards healthy young males as the subjects.  The antonym of the adjective efficacious is inefficacious but the word is rarely used when drug trials produce unsatisfactory results: the punchier "failed" is almost always used.  Under normal circumstances, the testing process can take many years, the industry usually referring to trials as phases:

Phase I: Safety Trial

Phase I trials are done to test a new biomedical intervention for the first time in a small group of people (typically 20-100) to evaluate safety.  Essentially, this determines the safe dosage range and identifies side effects.

Phase II: Efficacy Trial

Phase II trials are done to study an intervention in a larger group of people (several hundred or more depending on the product) to determine efficacy (ie whether it works as intended) and further to evaluate safety.

Phase III: Clinical Study

Phase III studies are done to study the efficacy of an intervention in large groups of trial participants (often thousands) by comparing the intervention to other standard or experimental interventions (or to non-interventional standard care).  Phase III studies are also used to monitor adverse effects and to collect information that will allow the intervention to be used safely.

Phase IV: Efficiency Study

Phase IV studies are done after the drug has been released and is being prescribed.  These studies are designed to monitor the effectiveness of the approved intervention in the general population and to collect information about any adverse effects associated with widespread use over longer periods of time.  They may also be used to investigate the potential use of the intervention in a different condition, or in combination with other therapies.

Proven efficacy: Adderall.

Adderall and Mydayis are trade names for a combination drug called mixed amphetamine salts (a mix of four salts of amphetamine).  In all Western jurisdictions  Belonging to a class of drugs known as stimulants, Adderall is a prescription medication and it contains two active ingredients: the amphetamines and dextroamphetamine.  As a prescribed medicine, primarily Adderall is used in the treatment of attention deficit hyperactivity disorder (ADHD), a neurobehavioral disorder characterized by symptoms such as inattention, hyperactivity, and impulsivity.  Adderall works by increasing the levels of certain neurotransmitters (most critically dopamine and norepinephrine) in the brain, these both mechanisms which play some role in regulating attention, focus, and impulse control.  Beyond ADHD, Adderall is sometimes prescribed off-label for the treatment of narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden, unpredictable episodes of sleep.

Adderall also has something of a cult following among those who seek to experience some of its more desirable side-effects.  Like many of the earlier amphetamines (most famously Tenuate Dospan (diethylpropion or amfepramone) an appetite suppressant of legendary efficacy), Adderall can assist in weight-loss and can safely be used for this by most people but because of its potential for dependence, it should be taken (for whatever purpose) only under clinical supervision.  For those prescribed Adderall, in some circumstances, it may continue to be taken (at the prescribed level) even if one is in a substance rehabilitation facility as was the case in 2013 when Lindsay Lohan completed a 48-hour drug detox at the Betty Ford Clinic in Indio, California.  Ms Lohan was prescribed Adderall after being diagnosed with ADHD but the standard protocol used by rehab clinics is that doctors routinely re-evaluate (1) the ADHA diagnosis and (2) the efficacy of the treatment regime.  Depending on their findings, doctors can prescribe alternative drugs or cease drug intervention entirely.  Ms Lohan was quoted as saying she’d been using Adderall "for years" and that she cannot function without it and her choice of rehab facility was once which would permit both smoking (tobacco) and the use of Adderall.

As she earlier explained it: “I have severe ADD. I can’t stand still.  So, I take Adderall for that; it calms me.”  Ms Lohan further noted she was not unaware there were those who took Adderall for its side-effects, notably weight loss or the ability to function effectively for extended durations without needing to sleep but that she wasn’t someone who needed to regulate her weight and that her sleeping patterns were normal.  However, the cult if anything is growing and in the US shortages of Adderall were reported (not for the first time) in late 2022.  The US Food and Drug Administration (FDA) responded by issuing a statement noting that while there was nothing unusual about episodic shortages of generic drugs at any given time because the profit margins are low and production is sometimes restricted to avoid a sacrifice in the opportunity cost vis-a-vis higher margin products, Adderall was “a special case because it is a controlled substance and the amount available for prescription is controlled by the Drug Enforcement Administration (DEA).”  The FDA added that because there had been “a tremendous increase in prescribing” because of virtual medicine (e-consultations) and a general trend towards over-prescribing and over-diagnosing, the periodic shortages were likely to continue.  THE FDA’s conclusion was that “if only those who needed these drugs got them, there probably wouldn't be a [stimulant medication] shortage” but the diagnosis of ADHD continues to grow and the desire for rapid weight-loss solutions remains strong.

Saturday, November 11, 2023

Thermidor

Thermidor (pronounced thur-mi-dawr or ter-mee-dawr (French))

(1) In the French Revolutionary calendar, the eleventh month of the year (19 (or 20) July to 17 (or 18) August); it was also called Fervidor (both terms now only of historic interest).

(2) As Thermidorian Reaction, a counterrevolution or coup d'état in some way recalling the events in Paris in July 1794.

(3) As lobster thermidor (both elements sometimes capitalized), a method of preparing the unfortunate crustacean for consumption.

Borrowed from French thermidor, from the Ancient Greek θέρμη (thérmē) (hot; heat) + δρον (dôron) (gift), the construct thus construct being thérm(ē) + (i) + dôr(on).  Thermidor is a noun & proper noun, thermion is a noun, thermidorien & thermidorian are nouns & adjective and thermionic is an adjective; the noun plural is thermidors.

In the history of revolutionary France, the noun thermidorian is used to refer to (1) a member of the politically moderate (a relative term) group who participated in the events of the 9th Thermidor (27 July 1794) and (2) a supporter of the reactionary movement following the coup d'état.  The use in political discourse was named after the play Thermidor (1891) by Victorien Sardou (1831–1908), itself named for the eleventh month of the French Republican Calendar.  The Coup d'état of 9 Thermidor (remembered in many reports as “the Fall of Maximilien Robespierre” (1758–1794)) was triggered by Robespierre's address to the National Convention on 26 July 1794), a speech which prompted his arrest the next day and his death on the guillotine the day after.  Due process is a quick business in revolutionary times.  Robespierre’s fateful words included a reference to “internal enemies, conspirators, and calumniators” within revolutionary movement but he declined to name names, giving rise among his colleagues to fears he was plotting another great purge of their numbers.

Comrade Stalin (left), an ice axe (centre) and comrade Trotsky (right).

Comrade Leon Trotsky (1879-1940; founder of the Fourth International) in The Revolution Betrayed: What Is the Soviet Union and Where Is It Going? (1936) had a feeling for the political phrase and labelled the state created by comrade Joseph Stalin (1878-1953; Soviet leader 1924-1953) a “Soviet Thermidor” because although Tsarist era capitalism wasn’t re-created (a la the monarchy in France not being restored in the 1790s), the combination of a bureaucracy supporting a personality cult (even if the latter was in 1936 still somewhat disguised) was “a counterrevolutionary regression” which betrayed what was achieved by comrade Vladimir Lenin (1870–1924; head of government of Russia or Soviet Union 1917-1924) between 1917-1924.  The phrase caught the imagination of many, notably those in the Partido Obrero de Unificación Marxista (The POUM, the Workers' Party of Marxist Unification), a non-communist Marxist party (a surprisingly populated fork of left-wing thought) which comrade Stalin correctly associated with Trotskyism.  The POUM was highly productive in thought but drifted increasingly far from the moorings of political reality although rhetoric which included polemics like “Stalinist Thermidorians have established in Russia the bureaucratic regime of a poisoned dictator.”  Agents of the Narodný komissariat vnutrennih del (NKVD, The People's Commissariat for Internal Affairs and one of the many predecessors to the KGB), answerable only to comrade Stalin, killed dozens of POUM’s Central Committee which ended the organization’s effectiveness for a generation.  In his prodigious memory, comrade Stalin filed away annoying phrases and in 1940 he had comrade Trotsky murdered in Mexico.  The murder weapon was an ice-axe.

Lobster Thermidor

Lobster Thermidor is a creamy, cheesy mixture of cooked lobster meat, egg yolks, and cognac or sherry, stuffed into a lobster shell and served usually with a an oven-browned cheese crust.  In restaurants, it’s an expensive dish because lobsters are now high-priced (there was a time when they were eaten almost only by the working class) but especially because it’s something with a high labor component.  Cooked at home, without the need to charge out labor, it’s a form of extravagance on a budget and it’s a favorite among the dinner party set and the ideal thing to serve as a prelude to discussions about house prices.

Ingredients

2 lobsters
2 tablespoons unsalted butter
2 tablespoons minced shallots
½ teaspoon minced garlic
2 tablespoons all-purpose flour
2 tablespoons cognac or brandy
¾ cup milk
¼ cup heavy cream
¾ teaspoon sea salt
¼ teaspoon ground white pepper
½ cup finely grated Parmesan, plus 2 tablespoons
1 tablespoon dry mustard powder
1 tablespoon finely chopped fresh tarragon leaves
2 teaspoons finely chopped parsley, plus additional for garnish
¼ cup shredded gruyere cheese

Lobster Thermidor is a signature dish at Texas-based Prime Steak & Seafood and their web-site includes photographs to encourage bookings.

Instructions (cooking lobster)

(1) Fill a large, deep stock pot with about 3-4 inches (75-100 mm) of water and add enough sea-salt to make it as salty as sea-water.  Some add aromatics like herbs or lemon to enhance the flavor but thermidor purists insist thing shouldn’t be done and that all such work must be done by the sauce.  Only ever cook live lobsters.  If this is not practical, pre-cooked lobsters are available.

 (2) Once the water has been brought to the boil, add the lobsters (head first) to the pot.  Steaming is the best way to cook lobster because the meat becomes less waterlogged and less flavor in lost to the liquid.

(3) Cover tightly and steam lobsters for 8 minutes per pound (.454 kg), for the first pound and then an additional 3 minutes per pound.  Thus, if the total weight being cooked is 2 lb, cooking time will be about 10 minutes.

(4) Using tongs, remove lobsters from the pot and check to ensure they are cooked.  A fully cooked lobster will register 135-140˚F (57-60˚C) when a quick-read thermometer is inserted into the thickest part of the tail (always insert device into the tail’s underside).

Instructions (lobster thermidor)

(5) Preheat oven to 375˚F (190˚C).

(6) Line a baking sheet with aluminium foil and set aside.

(7) Cut lobsters in half (length-wise and a sharp blade will be needed) and remove the tail meat.

(8) Gently twist claws from the body and gently crack with the back of a heavy knife to remove the meat.  Gently pull the front legs from the shell and discard (some retain them for decorative purposes.

(9) Chop the tail meat and claw meat into bite sized pieces and set aside.

(10) Place the halved lobster shells on the baking sheet and set aside.

(11) Melt butter in a deep skillet over medium heat.  Add shallots and garlic, stirring, until fragrant (about 30 seconds).  Add the flour and whisk to combine.

(12) Cook the flour mixture, stirring constantly to make a light roux (approximately 2 minutes).

(13) Add cognac and cook for 10 seconds, stirring constantly.

(14) Slowly add milk, stirring constantly until combined.  Bring to a boil, reduce the heat, and simmer until thick enough to coat the back of a spoon (approximately 2-3 minutes).

(15) Slowly add cream, stirring constantly, until thoroughly combined.  Continue cooking while stirring over medium heat for 1 minute (done correctly, this will have produced a very thick mix.  Season with salt and pepper.

(16) Remove from heat and stir in the parmesan cheese, mustard, tarragon, and parsley.  Fold in the lobster meat.

(17) Divide the mixture among the lobster shells and place stuffed side up on a clean baking sheet.

(18) Sprinkle the top of each lobster with the gruyere and broil until the top is golden brown (should take 5-6 minutes).

(19) Place 1 lobster half on each plate, garnish with additional parsley, and serve immediately.

Lindsay Lohan rescues a lobster from the ice, saving it from becoming lobster thermidor (the crustacean’s ultimate fate is unknown).  Lohan Beach Club, 2019.